PMID- 34922553 OWN - NLM STAT- MEDLINE DCOM- 20220221 LR - 20220223 IS - 1475-2840 (Electronic) IS - 1475-2840 (Linking) VI - 20 IP - 1 DP - 2021 Dec 18 TI - Association of healthy lifestyle including a healthy sleep pattern with incident type 2 diabetes mellitus among individuals with hypertension. PG - 239 LID - 10.1186/s12933-021-01434-z [doi] LID - 239 AB - BACKGROUND: Evidence is limited regarding the association of healthy lifestyle including sleep pattern with the risk of complicated type 2 diabetes mellitus (T2DM) among patients with hypertension. We aimed to investigate the associations of an overall healthy lifestyle including a healthy sleep pattern with subsequent development of T2DM among participants with hypertension compared to normotension, and to estimate how much of that risk could be prevented. METHODS: This study examined six lifestyle factors with T2DM cases among hypertension (227,966) and normotension (203,005) and their interaction in the UK Biobank. Low-risk lifestyle factors were defined as standard body mass index (BMI), drinking alcohol in moderation, nonsmoking, engaging in moderate- to vigorous-intensity physical activity, eating a high-quality diet, and maintaining a healthy sleep pattern. RESULTS: There were 12,403 incident T2DM cases during an average of 8.63 years of follow-up. Compared to those with 0 low-risk lifestyle factors, HRs for those with 5-6 were 0.14 (95% CI 0.10 to 0.19) for hypertensive participants, 0.13 (95% CI 0.08 to 0.19) for normotensive participants, respectively (p(trend) < 0.001). 76.93% of hypertensive participants were considerably less likely to develop T2DM if they adhered to five healthy lifestyle practices, increased to 81.14% if they followed 6-factors (with a healthy sleep pattern). Compared with hypertension adults, normotensive people gain more benefits if they stick to six healthy lifestyles [Population attributable risk (PAR%) 83.66%, 95% CI 79.45 to 87.00%, p for interaction = 0.0011]. CONCLUSIONS: Adherence to a healthy lifestyle pattern including a healthy sleep pattern is associated with lower risk of T2DM in hypertensives, and this benefit is even further in normotensives. CI - (c) 2021. The Author(s). FAU - Song, Zimin AU - Song Z AD - Department of Epidemiology and Biostatistics, School of Public Health, Peking University Health Science Center, 38 Xueyuan Road, Beijing, 100191, China. FAU - Yang, Ruotong AU - Yang R AD - Department of Epidemiology and Biostatistics, School of Public Health, Peking University Health Science Center, 38 Xueyuan Road, Beijing, 100191, China. FAU - Wang, Wenxiu AU - Wang W AD - Department of Epidemiology and Biostatistics, School of Public Health, Peking University Health Science Center, 38 Xueyuan Road, Beijing, 100191, China. FAU - Huang, Ninghao AU - Huang N AD - Department of Epidemiology and Biostatistics, School of Public Health, Peking University Health Science Center, 38 Xueyuan Road, Beijing, 100191, China. FAU - Zhuang, Zhenhuang AU - Zhuang Z AD - Department of Epidemiology and Biostatistics, School of Public Health, Peking University Health Science Center, 38 Xueyuan Road, Beijing, 100191, China. FAU - Han, Yuting AU - Han Y AD - Department of Epidemiology and Biostatistics, School of Public Health, Peking University Health Science Center, 38 Xueyuan Road, Beijing, 100191, China. FAU - Qi, Lu AU - Qi L AD - Department of Epidemiology, School of Public Health and Tropical Medicine, Tulane University, New Orleans, LA, USA. AD - Department of Nutrition, Harvard T.H. Chan School of Public Health, Boston, MA, USA. AD - Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA. FAU - Xu, Ming AU - Xu M AD - Department of Cardiology and Institute of Vascular Medicine, Peking University Third Hospital; Key Laboratory of Molecular Cardiovascular Sciences (Peking University), Ministry of Education; NHC Key Laboratory of Cardiovascular Molecular Biology and Regulatory Peptides; Key Laboratory of Cardiovascular Receptors Research, Beijing, 100191, China. AD - State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University, Beijing, 100191, China. FAU - Tang, Yi-da AU - Tang YD AD - Department of Cardiology and Institute of Vascular Medicine, Peking University Third Hospital; Key Laboratory of Molecular Cardiovascular Sciences (Peking University), Ministry of Education; NHC Key Laboratory of Cardiovascular Molecular Biology and Regulatory Peptides; Key Laboratory of Cardiovascular Receptors Research, Beijing, 100191, China. drtangyida@126.com. FAU - Huang, Tao AU - Huang T AUID- ORCID: 0000-0002-0328-1368 AD - Department of Epidemiology and Biostatistics, School of Public Health, Peking University Health Science Center, 38 Xueyuan Road, Beijing, 100191, China. huang.tao@pku.edu.cn. AD - Center for Intelligent Public Health, Academy for Artificial Intelligence, Peking University, Beijing, China. huang.tao@pku.edu.cn. LA - eng GR - 2020YFA0803800/Key Technology Research and Development Program of Shandong/ GR - BMU2018YJ002/Peking University Start-up Grant/ GR - 2020YFC2003401/National Key R&D Program of China/ GR - MC_QA137853/MRC_/Medical Research Council/United Kingdom GR - 88442Y0033/China-Canada Key Lab of Nutrition and Health at Beijing Technology and Business University- Grant/ GR - MC_PC_17228/MRC_/Medical Research Council/United Kingdom PT - Journal Article PT - Observational Study PT - Research Support, Non-U.S. Gov't DEP - 20211218 PL - England TA - Cardiovasc Diabetol JT - Cardiovascular diabetology JID - 101147637 SB - IM MH - Adult MH - Aged MH - Diabetes Mellitus, Type 2/diagnosis/epidemiology/*prevention & control MH - Diet, Healthy MH - Exercise MH - Female MH - *Healthy Lifestyle MH - Humans MH - Hypertension/diagnosis/epidemiology/*therapy MH - Incidence MH - Male MH - Middle Aged MH - Prospective Studies MH - Protective Factors MH - Risk Assessment MH - Risk Factors MH - *Risk Reduction Behavior MH - *Sleep MH - United Kingdom/epidemiology PMC - PMC8684653 OTO - NOTNLM OT - Hypertension OT - Lifestyle pattern OT - Type 2 diabetes mellitus OT - UK biobank COIS- All authors declare no support from companies for the submitted work; no relationships with companies that might have an interest in the submitted work in the previous 3 years; no spouses, partners, or children that have financial relationships that may be relevant to the submitted work; and no non-financial interests that may be relevant to the submitted work. EDAT- 2021/12/20 06:00 MHDA- 2022/02/22 06:00 PMCR- 2021/12/18 CRDT- 2021/12/19 20:29 PHST- 2021/09/08 00:00 [received] PHST- 2021/12/12 00:00 [accepted] PHST- 2021/12/19 20:29 [entrez] PHST- 2021/12/20 06:00 [pubmed] PHST- 2022/02/22 06:00 [medline] PHST- 2021/12/18 00:00 [pmc-release] AID - 10.1186/s12933-021-01434-z [pii] AID - 1434 [pii] AID - 10.1186/s12933-021-01434-z [doi] PST - epublish SO - Cardiovasc Diabetol. 2021 Dec 18;20(1):239. doi: 10.1186/s12933-021-01434-z.