PMID- 34922997
OWN - NLM
STAT- MEDLINE
DCOM- 20220519
LR  - 20220608
IS  - 1095-6808 (Electronic)
IS  - 0091-3022 (Linking)
VI  - 65
DP  - 2022 Apr
TI  - A scoping review of resting-state brain functional alterations in Type 2 
      diabetes.
PG  - 100970
LID - S0091-3022(21)00072-8 [pii]
LID - 10.1016/j.yfrne.2021.100970 [doi]
AB  - Resting-state functional magnetic resonance imaging (rs-fMRI) has been actively 
      used in the last decade to investigate brain functional connectivity alterations 
      in Type 2 Diabetes Mellitus (T2DM) to understand the neuropathophysiology of T2DM 
      in cognitive degeneration. Given the emergence of new analysis techniques, this 
      scoping review aims to map the rs-fMRI analysis techniques that have been applied 
      in the literature and reports the latest rs-fMRI findings that have not been 
      covered in previous reviews. Graph theory, the contemporary rs-fMRI analysis, has 
      been used to demonstrate altered brain topological organisations in people with 
      T2DM, which included altered degree centrality, functional connectivity strength, 
      the small-world architecture and network-based statistics. These alterations were 
      correlated with T2DM patients' cognitive performances. Graph theory also 
      contributes to identify unbiased seeds for seed-based analysis. The expanding 
      rs-fMRI analytical approaches continue to provide new evidence that helps to 
      understand the mechanisms of T2DM-related cognitive degeneration.
CI  - Copyright (c) 2021 Elsevier Inc. All rights reserved.
FAU - Chau, Anson C M
AU  - Chau ACM
AD  - Medical Imaging, Medical Radiation Science, Allied Health and Human Performance, 
      University of South Australia, Adelaide, Australia; Alliance for Research in 
      Exercise, Nutrition and Activity (ARENA), Allied Health and Human Performance, 
      University of South Australia, Adelaide, Australia. Electronic address: 
      anson.chau@unisa.edu.au.
FAU - Smith, Ashleigh E
AU  - Smith AE
AD  - Alliance for Research in Exercise, Nutrition and Activity (ARENA), Allied Health 
      and Human Performance, University of South Australia, Adelaide, Australia. 
      Electronic address: ashleigh.smith@unisa.edu.au.
FAU - Hordacre, Brenton
AU  - Hordacre B
AD  - IIMPACT in Health, Allied Health and Human Performance, University of South 
      Australia, Adelaide, Australia. Electronic address: 
      brenton.hordacre@unisa.edu.au.
FAU - Kumar, Saravana
AU  - Kumar S
AD  - IIMPACT in Health, Allied Health and Human Performance, University of South 
      Australia, Adelaide, Australia; Allied Health and Human Performance, University 
      of South Australia, Adelaide, Australia. Electronic address: 
      saravana.kumar@unisa.edu.au.
FAU - Cheung, Eva Y W
AU  - Cheung EYW
AD  - School of Medical and Health Sciences, Tung Wah College, Hong Kong. Electronic 
      address: evacheung@twc.edu.hk.
FAU - Mak, Henry K F
AU  - Mak HKF
AD  - Department of Diagnostic Radiology, LKS Faculty of Medicine, The University of 
      Hong Kong, Hong Kong; Alzheimer's Disease Research Network, The University of 
      Hong Kong, Hong Kong; State Key Laboratory for Brain and Cognitive Sciences, The 
      University of Hong Kong, Hong Kong. Electronic address: makkf@hku.hk.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20211216
PL  - United States
TA  - Front Neuroendocrinol
JT  - Frontiers in neuroendocrinology
JID - 7513292
SB  - IM
MH  - Brain/diagnostic imaging
MH  - *Diabetes Mellitus, Type 2
MH  - Humans
MH  - Magnetic Resonance Imaging/methods
OTO - NOTNLM
OT  - Brain functional connectivity
OT  - Brain topological organisation
OT  - Neurodegeneration
OT  - Resting-state functional magnetic resonance
OT  - Type 2 diabetes
EDAT- 2021/12/20 06:00
MHDA- 2022/05/20 06:00
CRDT- 2021/12/19 20:44
PHST- 2021/05/31 00:00 [received]
PHST- 2021/11/18 00:00 [revised]
PHST- 2021/12/07 00:00 [accepted]
PHST- 2021/12/20 06:00 [pubmed]
PHST- 2022/05/20 06:00 [medline]
PHST- 2021/12/19 20:44 [entrez]
AID - S0091-3022(21)00072-8 [pii]
AID - 10.1016/j.yfrne.2021.100970 [doi]
PST - ppublish
SO  - Front Neuroendocrinol. 2022 Apr;65:100970. doi: 10.1016/j.yfrne.2021.100970. Epub 
      2021 Dec 16.