PMID- 34923463
OWN - NLM
STAT- MEDLINE
DCOM- 20211221
LR  - 20211221
IS  - 0043-5147 (Print)
IS  - 0043-5147 (Linking)
VI  - 74
IP  - 10 cz 2
DP  - 2021
TI  - INSULIN RESISTANCE AS AN INDICATOR OF DIFFERENTIATION FOR THE FORMATION OF RISK 
      GROUPS FOR NON-ALCOHOLIC FATTY LIVER DISEASE IN PATIENTS WITHOUT TYPE 2 DIABETES 
      MELLITUS, AS A PART OF ONTOLOGICAL MODEL OF NON-ALCOHOLIC FATTY LIVER DISEASE.
PG  - 2593-2598
AB  - OBJECTIVE: The aim: Using cluster analysis, to identify a high-risk group for 
      NAFLD and develop a differential approach to examination, treatment and 
      prevention of the disease based on IR indices, among NAFLD and non-NAFLD patients 
      without type 2 diabetes mellitus (T2DM). PATIENTS AND METHODS: Materials and 
      methods: Clinical, anthropometric, laboratory methods, ultrasound, computational 
      and statistical techniques were applied. RESULTS: Results: Cluster analysis was 
      performed on the laboratory tests results: glucose, insulin, HOMA-IR index, HOMA2 
      Calculator (%B - beta-cell function, %S - insulin sensitivity, IR - insulin 
      resistance). 5 groups of patients were formed, according to increasing HOMA-IR 
      index and IR. Group II was found to be transient in IR formation, it included the 
      majority of non-NAFLD patients (87%), and we consider it to be the risk group for 
      NAFLD. Group V - with the highest IR scores, where 92% of patients had NAFLD and 
      73% had a high Fatty Liver Index - is considered to be a very high-risk group for 
      developing T2DM. CONCLUSION: Conclusions: 1. According to the results of cluster 
      analysis, 5 groups of patients with different IR levels were identified. 2. In 
      the second group, where non-NAFLD patients predominate, insulin resistance begins 
      to form. 3. Groups III and IV - patients with high HOMA-IR index - had 
      significant ultrasound findings indicating hepatic steatosis. 4. Group V included 
      patients with NAFLD, with high HOMA-IR index and the highest risk of developing 
      T2DM.
FAU - Nosko, Natalia O
AU  - Nosko NO
AD  - SHUPYK NATIONAL HEALTHCARE UNIVERSITY OF UKRAINE, KYIV, UKRAINE.
FAU - Kharchenko, Viacheslav V
AU  - Kharchenko VV
AD  - SHUPYK NATIONAL HEALTHCARE UNIVERSITY OF UKRAINE, KYIV, UKRAINE.
LA  - eng
PT  - Journal Article
PL  - Poland
TA  - Wiad Lek
JT  - Wiadomosci lekarskie (Warsaw, Poland : 1960)
JID - 9705467
SB  - IM
MH  - Cell Differentiation
MH  - *Diabetes Mellitus, Type 2/complications
MH  - Humans
MH  - *Insulin Resistance
MH  - *Non-alcoholic Fatty Liver Disease
OTO - NOTNLM
OT  - HOMA-IR index
OT  - HOMA2 Calculator
OT  - NAFLD
OT  - insulin resistance
OT  - ontology
EDAT- 2021/12/20 06:00
MHDA- 2021/12/22 06:00
CRDT- 2021/12/19 21:04
PHST- 2021/12/19 21:04 [entrez]
PHST- 2021/12/20 06:00 [pubmed]
PHST- 2021/12/22 06:00 [medline]
PST - ppublish
SO  - Wiad Lek. 2021;74(10 cz 2):2593-2598.