PMID- 34924065
OWN - NLM
STAT- MEDLINE
DCOM- 20220817
LR  - 20220817
IS  - 1601-5215 (Electronic)
IS  - 0924-2708 (Linking)
VI  - 34
IP  - 4
DP  - 2022 Aug
TI  - Peripheral inflammatory markers associated with brain volume reduction in 
      patients with bipolar I disorder.
PG  - 191-200
LID - 10.1017/neu.2021.39 [doi]
AB  - BACKGROUND: Neuroinflammation and brain structural abnormalities are found in 
      bipolar disorder (BD). Elevated levels of cytokines and chemokines have been 
      detected in the serum and cerebrospinal fluid of patients with BD. This study 
      investigated the association between peripheral inflammatory markers and brain 
      subregion volumes in BD patients. METHODS: Euthymic patients with bipolar I 
      disorder (BD-I) aged 20-45 years underwent whole-brain magnetic resonance 
      imaging. Plasma levels of monocyte chemoattractant protein-1 (MCP-1), 
      chitinase-3-like protein 1 (also known as YKL-40), fractalkine (FKN), soluble 
      tumour necrosis factor receptor-1 (sTNF-R1), interleukin-1beta, and transforming 
      growth factor-beta1 were measured on the day of neuroimaging. Clinical data were 
      obtained from medical records and interviewing patients and reliable others. 
      RESULTS: We recruited 31 patients with a mean age of 29.5 years. In multivariate 
      regression analysis, plasma level YKL-40, a chemokine, was the most common 
      inflammatory marker among these measurements displaying significantly negative 
      association with the volume of various brain subareas across the frontal, 
      temporal, and parietal lobes. Higher YKL-40 and sTNF-R1 levels were both 
      significantly associated with lower volumes of the left anterior cingulum, left 
      frontal lobe, right superior temporal gyrus, and supramarginal gyrus. A greater 
      number of total lifetime mood episodes were also associated with smaller volumes 
      of the right caudate nucleus and bilateral frontal lobes. CONCLUSIONS: The volume 
      of brain regions known to be relevant to BD-I may be diminished in relation to 
      higher plasma level of YKL-40, sTNF-R1, and more lifetime mood episodes. 
      Macrophage and macrophage-like cells may be involved in brain volume reduction 
      among BD-I patients.
FAU - Tsai, Shang-Ying
AU  - Tsai SY
AUID- ORCID: 0000-0001-5662-0055
AD  - Department of Psychiatry, School of Medicine, College of Medicine, Taipei Medical 
      University, Taipei, Taiwan.
AD  - Department of Psychiatry and Psychiatric Research Center, Taipei Medical 
      University Hospital, Taipei Medical University, Taipei, Taiwan.
FAU - Sajatovic, Martha
AU  - Sajatovic M
AD  - Department of Psychiatry, University Hospitals Cleveland Medical Center, Case 
      Western Reserve University School of Medicine, Cleveland, Ohio, USA.
FAU - Hsu, Jung-Lung
AU  - Hsu JL
AD  - Department of Neurology, New Taipei Municipal TuCheng Hospital, Chang Gung 
      Memorial Hospital and Chang Gung University, New Taipei City, Taiwan.
AD  - Graduate Institute of Humanities in Medicine and Research Center for Brain and 
      Consciousness, College of Humanities And Social Sciences, Taipei Medical 
      University, Taipei, Taiwan.
FAU - Chung, Kuo-Hsuan
AU  - Chung KH
AD  - Department of Psychiatry, School of Medicine, College of Medicine, Taipei Medical 
      University, Taipei, Taiwan.
AD  - Department of Psychiatry and Psychiatric Research Center, Taipei Medical 
      University Hospital, Taipei Medical University, Taipei, Taiwan.
FAU - Chen, Pao-Huan
AU  - Chen PH
AD  - Department of Psychiatry, School of Medicine, College of Medicine, Taipei Medical 
      University, Taipei, Taiwan.
AD  - Department of Psychiatry and Psychiatric Research Center, Taipei Medical 
      University Hospital, Taipei Medical University, Taipei, Taiwan.
FAU - Huang, Yu-Jui
AU  - Huang YJ
AD  - Department of Psychiatry and Psychiatric Research Center, Taipei Medical 
      University Hospital, Taipei Medical University, Taipei, Taiwan.
LA  - eng
PT  - Journal Article
DEP - 20211220
PL  - England
TA  - Acta Neuropsychiatr
JT  - Acta neuropsychiatrica
JID - 9612501
RN  - 0 (Biomarkers)
RN  - 0 (Chitinase-3-Like Protein 1)
RN  - 0 (Cytokines)
SB  - IM
MH  - Adult
MH  - Biomarkers
MH  - *Bipolar Disorder
MH  - Brain/metabolism
MH  - Chitinase-3-Like Protein 1/metabolism
MH  - Cytokines/metabolism
MH  - Humans
MH  - Magnetic Resonance Imaging
OTO - NOTNLM
OT  - Chemokine
OT  - YKL-40
OT  - bipolar I disorder
OT  - brain volume
OT  - chitinase-3-like protein 1
OT  - sTNF-R1
EDAT- 2021/12/21 06:00
MHDA- 2022/08/18 06:00
CRDT- 2021/12/20 05:35
PHST- 2021/12/21 06:00 [pubmed]
PHST- 2022/08/18 06:00 [medline]
PHST- 2021/12/20 05:35 [entrez]
AID - S0924270821000399 [pii]
AID - 10.1017/neu.2021.39 [doi]
PST - ppublish
SO  - Acta Neuropsychiatr. 2022 Aug;34(4):191-200. doi: 10.1017/neu.2021.39. Epub 2021 
      Dec 20.