PMID- 34925086
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20211221
IS  - 1664-0640 (Print)
IS  - 1664-0640 (Electronic)
IS  - 1664-0640 (Linking)
VI  - 12
DP  - 2021
TI  - Altered Functional Connectivity in a Triple-Network Model in Autism With 
      Co-occurring Attention Deficit Hyperactivity Disorder.
PG  - 736755
LID - 10.3389/fpsyt.2021.736755 [doi]
LID - 736755
AB  - Purpose: This study aimed to explore alterations in functional connectivity (FC) 
      within and between default mode network (DMN), central executive network, and 
      salience network in autism spectrum disorder (ASD) with co-occurring attention 
      deficit hyperactivity disorder (ADHD). Method: A total of 135 individuals' date 
      of the Autism Brain Imaging Data Exchange II was used to compare the ASD+ADHD 
      group with the ASD group in relation to the abnormal within-network and 
      between-network connectivity of the ASD group relative to the TD group; 
      consequently, the correlation analysis between abnormal FC and behavior was 
      performed. Results: The ASD+ADHD group exhibited decreased within-network 
      connectivity in the precuneus of the ventral DMN compared with the ASD group. 
      Among the three groups, the ASD+ADHD group showed lower connectivity, whereas the 
      ASD group had higher connectivity than the TD group, although the effect of the 
      separate post hoc test was not significant. Meanwhile, the ASD+ADHD group showed 
      increased between-network connectivity between the ventral DMN and dorsal DMN and 
      between the ventral DMN and left executive control network, compared with the ASD 
      and TD groups. Conclusion: Dysfunction of DMN in the "triple-network model" is 
      the core evidence for ASD with co-occurring ADHD.
CI  - Copyright (c) 2021 Wang, Li and Niu.
FAU - Wang, Kai
AU  - Wang K
AD  - Department of Pediatrics, First Affiliated Hospital, Zhengzhou University, 
      Zhengzhou, China.
FAU - Li, Ke
AU  - Li K
AD  - Department of Child Healthcare, Children's Hospital Affiliated to Zhengzhou 
      University, Zhengzhou, China.
FAU - Niu, Xiaoyu
AU  - Niu X
AD  - Department of Pediatrics, First Affiliated Hospital, Zhengzhou University, 
      Zhengzhou, China.
LA  - eng
PT  - Journal Article
DEP - 20211202
PL  - Switzerland
TA  - Front Psychiatry
JT  - Frontiers in psychiatry
JID - 101545006
PMC - PMC8674431
OTO - NOTNLM
OT  - attention deficit hyperactivity disorder
OT  - autism
OT  - co-occurring
OT  - default mode network
OT  - triple-network model
COIS- The authors declare that the research was conducted in the absence of any 
      commercial or financial relationships that could be construed as a potential 
      conflict of interest.
EDAT- 2021/12/21 06:00
MHDA- 2021/12/21 06:01
PMCR- 2021/12/02
CRDT- 2021/12/20 06:05
PHST- 2021/07/06 00:00 [received]
PHST- 2021/11/04 00:00 [accepted]
PHST- 2021/12/20 06:05 [entrez]
PHST- 2021/12/21 06:00 [pubmed]
PHST- 2021/12/21 06:01 [medline]
PHST- 2021/12/02 00:00 [pmc-release]
AID - 10.3389/fpsyt.2021.736755 [doi]
PST - epublish
SO  - Front Psychiatry. 2021 Dec 2;12:736755. doi: 10.3389/fpsyt.2021.736755. 
      eCollection 2021.