PMID- 34925089
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20211221
IS  - 1664-0640 (Print)
IS  - 1664-0640 (Electronic)
IS  - 1664-0640 (Linking)
VI  - 12
DP  - 2021
TI  - Shared and Distinct Fractional Amplitude of Low-Frequency Fluctuation Patterns in 
      Major Depressive Disorders With and Without Gastrointestinal Symptoms.
PG  - 744898
LID - 10.3389/fpsyt.2021.744898 [doi]
LID - 744898
AB  - Objective: Gastrointestinal (GI) symptoms are fairly common somatic symptoms in 
      depressed patients. The purpose of this study was to explore the influence of 
      concomitant GI symptoms on the fractional amplitude of low-frequency fluctuation 
      (fALFF) patterns in patients with major depressive disorder (MDD) and investigate 
      the connection between aberrant fALFF and clinical characteristics. Methods: This 
      study included 35 MDD patients with GI symptoms (GI-MDD patients), 17 MDD 
      patients without GI symptoms (nGI-MDD patients), and 28 healthy controls (HCs). 
      The fALFF method was used to analyze the resting-state functional magnetic 
      resonance imaging data. Correlation analysis and pattern classification were 
      employed to investigate the relationship of the fALFF patterns with the clinical 
      characteristics of patients. Results: GI-MDD patients exhibited higher scores in 
      the HRSD-17 and suffered more severe insomnia, anxiety/somatization, and weight 
      loss than nGI-MDD patients. GI-MDD patients showed higher fALFF in the right 
      superior frontal gyrus (SFG)/middle frontal gyrus (MFG) and lower fALFF in the 
      left superior medial prefrontal cortex (MPFC) compared with nGI-MDD patients. A 
      combination of the fALFF values of these two clusters could be applied to 
      discriminate GI-MDD patients from nGI-MDD patients, with accuracy, sensitivity, 
      and specificity of 86.54, 94.29, and 70.59%, respectively. Conclusion: GI-MDD 
      patients showed more severe depressive symptoms. Increased fALFF in the right 
      SFG/MFG and decreased fALFF in the left superior MPFC might be distinctive 
      neurobiological features of MDD patients with GI symptoms.
CI  - Copyright (c) 2021 Fu, Li, Yan, Chen, Liu, Zhao and Guo.
FAU - Fu, Xiaoya
AU  - Fu X
AD  - National Clinical Research Center for Mental Disorders, Department of Psychiatry, 
      The Second Xiangya Hospital of Central South University, Changsha, China.
FAU - Li, Huabing
AU  - Li H
AD  - Department of Radiology, The Second Xiangya Hospital of Central South University, 
      Changsha, China.
FAU - Yan, Meiqi
AU  - Yan M
AD  - National Clinical Research Center for Mental Disorders, Department of Psychiatry, 
      The Second Xiangya Hospital of Central South University, Changsha, China.
FAU - Chen, Jindong
AU  - Chen J
AD  - National Clinical Research Center for Mental Disorders, Department of Psychiatry, 
      The Second Xiangya Hospital of Central South University, Changsha, China.
FAU - Liu, Feng
AU  - Liu F
AD  - Department of Radiology, Tianjin Medical University General Hospital, Tianjin, 
      China.
FAU - Zhao, Jingping
AU  - Zhao J
AD  - National Clinical Research Center for Mental Disorders, Department of Psychiatry, 
      The Second Xiangya Hospital of Central South University, Changsha, China.
FAU - Guo, Wenbin
AU  - Guo W
AD  - National Clinical Research Center for Mental Disorders, Department of Psychiatry, 
      The Second Xiangya Hospital of Central South University, Changsha, China.
AD  - Department of Psychiatry, The Third People's Hospital of Foshan, Foshan, China.
LA  - eng
PT  - Journal Article
DEP - 20211202
PL  - Switzerland
TA  - Front Psychiatry
JT  - Frontiers in psychiatry
JID - 101545006
PMC - PMC8674438
OTO - NOTNLM
OT  - fractional amplitude low-frequency fluctuation
OT  - functional magnet resonance imaging (fMRI)
OT  - gastrointestinal symptoms
OT  - major depressive disorder
OT  - somatic symptoms
COIS- The authors declare that the research was conducted in the absence of any 
      commercial or financial relationships that could be construed as a potential 
      conflict of interest.
EDAT- 2021/12/21 06:00
MHDA- 2021/12/21 06:01
PMCR- 2021/12/02
CRDT- 2021/12/20 06:05
PHST- 2021/07/21 00:00 [received]
PHST- 2021/10/29 00:00 [accepted]
PHST- 2021/12/20 06:05 [entrez]
PHST- 2021/12/21 06:00 [pubmed]
PHST- 2021/12/21 06:01 [medline]
PHST- 2021/12/02 00:00 [pmc-release]
AID - 10.3389/fpsyt.2021.744898 [doi]
PST - epublish
SO  - Front Psychiatry. 2021 Dec 2;12:744898. doi: 10.3389/fpsyt.2021.744898. 
      eCollection 2021.