PMID- 34925567
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220429
IS  - 1841-0987 (Print)
IS  - 1843-066X (Electronic)
IS  - 1841-0987 (Linking)
VI  - 17
IP  - 2
DP  - 2021 Apr-Jun
TI  - THYROTROPIN-RECEPTOR ANTIBODIES, IMMUNOGLOBULIN E AND ANTINUCLEAR ANTIBODIES IN 
      PATIENTS WITH GRAVES' DISEASE AND GRAVES' ORBITOPATHY.
PG  - 194-199
LID - 10.4183/aeb.2021.194 [doi]
AB  - CONTEXT: Thyrotropin-receptor antibodies (TRAb) are biomarkers of Graves' disease 
      (GD) and Graves' orbitopathy (GO). Elevated immunoglobulin E (IgE) and 
      antinuclear antibodies (ANA) were also found in GD patients. OBJECTIVE: We aimed 
      to assess TRAb, IgE and ANA in GD and GO patients and to evaluate the 
      relationship between the immunological markers and smoking. DESIGN: This was a 
      comparative cross-sectional study carried out in a single tertiary care center 
      from June 2018 to January 2020. SUBJECTS AND METHODS: A total of 103 GD patients 
      (mean age 51.2, 84 females) were divided into three subgroups: moderate-to-severe 
      GO (n=36), mild GO (n=32) and "only GD" subgroup (n=35). Forty healthy controls 
      (HC) (mean age 51.2, 36 females) were also included. TRAb were measured by a 
      thyrotropin-binding inhibitory immunoglobulin (TBII) assay in GD patients; IgE 
      and ANA - by an enzyme-linked immunosorbent assay in all subjects. RESULTS: GD 
      patients had higher IgE-positivity rate (p=0.04) and similar ANA-positivity 
      compared to HC. Moderate-to-severe GO subgroup had the highest TBII (p<0.01), the 
      lowest TBII-negativity rate (p<0.01) and the highest ANA-positivity rate (p=0.03) 
      and was the only subgroup whose IgE-positivity rate was significantly higher than 
      HC (25% vs. 7.5%). Mild GO and "only GD" patients had comparable TBII, 
      TBII-negativity rate, IgE and ANA.Both GO subgroups had significantly higher 
      smoking rate than "only GD" patients. Smoking was positively associated with IgE 
      positivity (phi=0.22, p=0.03), and negatively with TBII negativity rate (phi=-0.24, 
      p=0.02). CONCLUSIONS: GD patients exhibit different immunological patterns 
      depending on the presence and severity of GO. Smoking might be just one of the 
      factors responsible for the clinical and immunological variety of GD. Further 
      studies are needed.
CI  - (c)by Acta Endocrinologica Foundation.
FAU - Stoynova, M
AU  - Stoynova M
AD  - Medical University of Sofia, University Hospital of Endocrinology, Sofia, 
      Bulgaria.
FAU - Shinkov, A
AU  - Shinkov A
AD  - Medical University of Sofia, University Hospital of Endocrinology, Sofia, 
      Bulgaria.
FAU - Kirilov, G
AU  - Kirilov G
AD  - Medical University of Sofia, University Hospital of Endocrinology, Sofia, 
      Bulgaria.
FAU - Kovatcheva, R
AU  - Kovatcheva R
AD  - Medical University of Sofia, University Hospital of Endocrinology, Sofia, 
      Bulgaria.
LA  - eng
PT  - Journal Article
PL  - Romania
TA  - Acta Endocrinol (Buchar)
JT  - Acta endocrinologica (Bucharest, Romania : 2005)
JID - 101269720
PMC - PMC8665252
OTO - NOTNLM
OT  - Graves' disease
OT  - Graves' orbitopathy
OT  - antinuclear antibodies
OT  - immunoglobulin E
OT  - thyrotropin-receptor antibodies
COIS- The authors declare that they have no conflict of interest.
EDAT- 2021/12/21 06:00
MHDA- 2021/12/21 06:01
PMCR- 2021/10/01
CRDT- 2021/12/20 06:08
PHST- 2021/12/20 06:08 [entrez]
PHST- 2021/12/21 06:00 [pubmed]
PHST- 2021/12/21 06:01 [medline]
PHST- 2021/10/01 00:00 [pmc-release]
AID - aeb.2021.194 [pii]
AID - 10.4183/aeb.2021.194 [doi]
PST - ppublish
SO  - Acta Endocrinol (Buchar). 2021 Apr-Jun;17(2):194-199. doi: 10.4183/aeb.2021.194.