PMID- 34926522
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20211221
IS  - 2296-858X (Print)
IS  - 2296-858X (Electronic)
IS  - 2296-858X (Linking)
VI  - 8
DP  - 2021
TI  - Effect of Neuromuscular Electrical Stimulation After Total Knee Arthroplasty: A 
      Systematic Review and Meta-Analysis of Randomized Controlled Trials.
PG  - 779019
LID - 10.3389/fmed.2021.779019 [doi]
LID - 779019
AB  - Background: This systematic review and meta-analysis aimed to evaluate the effect 
      of neuromuscular electrical stimulation (NMES) on quadriceps muscle strength, 
      pain, and function outcomes following total knee arthroplasty (TKA). Methods: 
      PubMed/Medline, Embase, Web of Science, CENTRAL, Scopus, PsycINFO, PEDro, CINAHL, 
      CNKI, and Wanfang were systematically searched for randomized controlled trials 
      (RCTs) from their inception to 18 June 2021. Results: Nine RCTs that involving 
      691 patients were included in the meta-analysis. Our pooled analysis showed that 
      NMES improved quadriceps muscle strength after TKA within 1 months [standardized 
      mean difference (SMD): 0.81; 95% CI: 0.51-1.11], 1-2 months (SMD: 0.55; 95% CI: 
      0.13-0.97), 3-4 months (SMD: 0.42; 95% CI: 0.18-0.66), and 12-13 months (SMD: 
      0.46; 95% CI: 0.18-0.74), pain between 1 and 2 months [mean difference (MD): 
      -0.62; 95% CI: -1.04 to -0.19], pain between 3 and 6 months (MD: -0.44; 95% CI: 
      -0.74 to -0.14) Western Ontario and McMaster Universities Osteoarthritis Index 
      (WOMAC) between 3 and 4 months (MD: -0.43; 95% CI: -0.82 to -0.05), timed up and 
      go test (TUG) within 1 month (MD: -2.23; 95% CI: -3.40 to -1.07), 3 minutes walk 
      test between 3 and 6 months (MD: 28.35; 95% CI: 14.55-42.15), and SF-36 MCS 
      between 3 and 6 months after TKA (MD: 4.20, 95% CI: 2.41-5.98). Conclusion: As a 
      supplementary treatment after TKA, postoperative NMES could improve the 
      short-term to long-term quadriceps muscle strength, mid-term pain, and mid-term 
      function following TKA. However, many outcomes failed to achieve statistically 
      meaningful changes and minimal clinically important difference (MCID), thus the 
      clinical benefits remained to be confirmed. Level of Evidence: Therapeutic level 
      I. Systematic Review Registration: https://www.crd.york.ac.uk/PROSPERO/, 
      identifier CRD42021265609.
CI  - Copyright (c) 2021 Peng, Wang, Zeng, Wu, Si and Shen.
FAU - Peng, Linbo
AU  - Peng L
AD  - Department of Orthopedics, Orthopedic Research Institute, West China Hospital, 
      Sichuan University, Chengdu, China.
FAU - Wang, Kexin
AU  - Wang K
AD  - Department of Clinical Research Management, West China Hospital, Sichuan 
      University, Chengdu, China.
FAU - Zeng, Yi
AU  - Zeng Y
AD  - Department of Orthopedics, Orthopedic Research Institute, West China Hospital, 
      Sichuan University, Chengdu, China.
FAU - Wu, Yuangang
AU  - Wu Y
AD  - Department of Orthopedics, Orthopedic Research Institute, West China Hospital, 
      Sichuan University, Chengdu, China.
FAU - Si, Haibo
AU  - Si H
AD  - Department of Orthopedics, Orthopedic Research Institute, West China Hospital, 
      Sichuan University, Chengdu, China.
FAU - Shen, Bin
AU  - Shen B
AD  - Department of Orthopedics, Orthopedic Research Institute, West China Hospital, 
      Sichuan University, Chengdu, China.
LA  - eng
PT  - Systematic Review
DEP - 20211203
PL  - Switzerland
TA  - Front Med (Lausanne)
JT  - Frontiers in medicine
JID - 101648047
PMC - PMC8677678
OTO - NOTNLM
OT  - function
OT  - meta-analysis
OT  - neuromuscular electrical stimulation
OT  - pain
OT  - quadriceps muscle strength
OT  - systematic review
OT  - total knee arthroplasty
COIS- The authors declare that the research was conducted in the absence of any 
      commercial or financial relationships that could be construed as a potential 
      conflict of interest.
EDAT- 2021/12/21 06:00
MHDA- 2021/12/21 06:01
PMCR- 2021/12/03
CRDT- 2021/12/20 06:18
PHST- 2021/09/17 00:00 [received]
PHST- 2021/11/08 00:00 [accepted]
PHST- 2021/12/20 06:18 [entrez]
PHST- 2021/12/21 06:00 [pubmed]
PHST- 2021/12/21 06:01 [medline]
PHST- 2021/12/03 00:00 [pmc-release]
AID - 10.3389/fmed.2021.779019 [doi]
PST - epublish
SO  - Front Med (Lausanne). 2021 Dec 3;8:779019. doi: 10.3389/fmed.2021.779019. 
      eCollection 2021.