PMID- 34927072
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20211221
IS  - 2632-010X (Electronic)
IS  - 2632-010X (Linking)
VI  - 14
DP  - 2021 Jan-Dec
TI  - An Unusual Case of EBV-Negative Primary CNS Lymphoma of Natural Killer/T-Cell 
      Lineage.
PG  - 2632010X211065692
LID - 10.1177/2632010X211065692 [doi]
LID - 2632010X211065692
AB  - Extranodal NK/T-cell lymphoma (ENKTL) is a well-defined cytotoxic lymphoma 
      strongly associated with Epstein-Barr virus (EBV) infection, commonly affecting 
      the nasopharynx and upper aerodigestive tract. Primary central nervous system 
      (CNS) involvement is rare, and only 17 cases were previously reported in the 
      literature. Here, we report the case of a 44-year-old male admitted with a 
      3-month history of personality changes and progressive right leg weakness. Brain 
      magnetic resonance imaging studies (MRIs) revealed multiple rim-enhancing brain 
      lesions bilaterally. An extensive clinical and laboratory workup was unrevealing, 
      and 2 brain biopsies were initially considered inconclusive. Pertinently, no 
      systemic lymphoproliferative disorder was identified. The patient initially 
      experienced remarkable clinical improvement with dexamethasone, pulse 
      methylprednisolone, and rituximab therapy. However, he eventually had rapid 
      clinical deterioration, was found to have increased brain lesions, and died 
      nearly 6 months after the initial presentation. During this time, the second 
      brain biopsy was found to show involvement by T-cell lymphoma of NK-cell lineage, 
      which was EBV negative. No post-mortem examination was done to identify any 
      systemic lymphoma. This case serves to expand the spectrum of lymphomas involving 
      the CNS.
CI  - (c) The Author(s) 2021.
FAU - Kajtazi, Naim I
AU  - Kajtazi NI
AUID- ORCID: 0000-0002-9983-3584
AD  - Department of Neurology, National Neurosciences Institute, King Fahad Medical 
      City, Riyadh, KSA.
FAU - Bafaquh, Mohammed
AU  - Bafaquh M
AD  - Department of Neurosurgery, National Neurosciences Institute, King Fahad Medical 
      City, Riyadh, KSA.
FAU - Ghamdi, Juman Al
AU  - Ghamdi JA
AD  - Medical Imaging Administration, Neurointervention Radiology, King Fahad Medical 
      City, Riyadh, KSA.
FAU - AlEissa, Zahra
AU  - AlEissa Z
AD  - Department of Neurology, National Neurosciences Institute, King Fahad Medical 
      City, Riyadh, KSA.
FAU - Shmeikh, Arwa Al
AU  - Shmeikh AA
AD  - Department of Neurosurgery, National Neurosciences Institute, King Fahad Medical 
      City, Riyadh, KSA.
FAU - Alsaeed, Ali
AU  - Alsaeed A
AD  - Internal Medicine Department, Infectious Diseases, King Fahad Medical City, 
      Riyadh, KSA.
FAU - Sulaiman, Tarek
AU  - Sulaiman T
AD  - Internal Medicine Department, Infectious Diseases, King Fahad Medical City, 
      Riyadh, KSA.
FAU - Vizcaino, M Adelita
AU  - Vizcaino MA
AD  - Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN, USA.
FAU - Al Hameed, Majed
AU  - Al Hameed M
AD  - Department of Neurology, National Neurosciences Institute, King Fahad Medical 
      City, Riyadh, KSA.
FAU - Raghunathan, Aditya
AU  - Raghunathan A
AD  - Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN, USA.
LA  - eng
PT  - Journal Article
DEP - 20211212
PL  - United States
TA  - Clin Pathol
JT  - Clinical pathology (Thousand Oaks, Ventura County, Calif.)
JID - 101741182
PMC - PMC8671822
OTO - NOTNLM
OT  - Epstein-Barr virus (EBV) infection
OT  - NK (natural killer) cells
OT  - Primary CNS lymphoma
OT  - extranodal NK/T-cell lymphoma (ENKTL)
COIS- Declaration of Conflicting Interests: The author(s) declared no potential 
      conflicts of interest with respect to the research, authorship, and/or 
      publication of this article.
EDAT- 2021/12/21 06:00
MHDA- 2021/12/21 06:01
PMCR- 2021/12/12
CRDT- 2021/12/20 06:26
PHST- 2021/09/12 00:00 [received]
PHST- 2021/11/01 00:00 [accepted]
PHST- 2021/12/20 06:26 [entrez]
PHST- 2021/12/21 06:00 [pubmed]
PHST- 2021/12/21 06:01 [medline]
PHST- 2021/12/12 00:00 [pmc-release]
AID - 10.1177_2632010X211065692 [pii]
AID - 10.1177/2632010X211065692 [doi]
PST - epublish
SO  - Clin Pathol. 2021 Dec 12;14:2632010X211065692. doi: 10.1177/2632010X211065692. 
      eCollection 2021 Jan-Dec.