PMID- 34927520 OWN - NLM STAT- MEDLINE DCOM- 20220112 LR - 20220430 IS - 1941-837X (Electronic) IS - 1369-6998 (Linking) VI - 25 IP - 1 DP - 2022 Jan-Dec TI - Real-world burden of chemotherapy-induced myelosuppression in patients with small cell lung cancer: a retrospective analysis of electronic medical data from community cancer care providers. PG - 108-118 LID - 10.1080/13696998.2021.2020570 [doi] AB - AIMS: Chemotherapy-induced myelosuppression, which commonly exhibits as neutropenia, anemia, or thrombocytopenia, represents a substantial burden for patients with cancer that affects health-related quality of life and increases healthcare resource utilization (HCRU). We evaluated the burden of myelosuppression among chemotherapy-treated patients with small cell lung cancer (SCLC) using real-world data from community cancer care providers in the Western United States. MATERIALS AND METHODS: This was a retrospective, observational analysis of electronic medical records (EMRs) from Providence St. Joseph Health hospital-associated oncology clinics between January 2016 and December 2019. Patient demographics were assessed from the date of first SCLC diagnosis in adult patients with chemotherapy-induced grade >/=3 myelosuppression in first-line (1L) or second-line-and-beyond (2L+) treatment settings. Myelosuppressive adverse events (AEs), treatment patterns, and HCRU were assessed from the date of chemotherapy initiation (index date) until 12 months, date of the last visit, date of death, or study end, whichever occurred earliest. RESULTS: Of 347 eligible patients with SCLC who had received chemotherapy (mean age 66; 49% female), all had received at least 1L treatment, and 103 (29.7%) had a 2L + treatment recorded within the EMR during the study period. Of 338 evaluable patients with longitudinal laboratory data, 206 (60.9%) experienced grade >/=3 myelosuppressive AEs, most commonly neutropenia, anemia, and thrombocytopenia (44.9, 41.1, and 25.4 per 100 patients, respectively). Rates of granulocyte colony-stimulating factor use and red blood cell transfusions were 47.0 and 41.7 per 100 patients, respectively. There was a trend toward increasing the use of supportive care interventions and visits to inpatient and outpatient facilities in patients with myelosuppressive AEs in more than one cell lineage. CONCLUSIONS: Chemotherapy-induced myelosuppression places a substantial real-world burden on patients with SCLC in the community cancer care setting. Innovations to protect bone marrow from chemotherapy-induced damage have the potential to reduce this burden. FAU - Epstein, Robert S AU - Epstein RS AUID- ORCID: 0000-0001-5031-302X AD - Epstein Health, LLC, Woodcliff Lake, NJ, USA. FAU - Weerasinghe, Roshanthi K AU - Weerasinghe RK AD - Providence Health & Services, Renton, WA, USA. FAU - Parrish, Amy S AU - Parrish AS AD - Providence Health & Services, Renton, WA, USA. FAU - Krenitsky, JoAnn AU - Krenitsky J AD - Epstein Health, LLC, Woodcliff Lake, NJ, USA. FAU - Sanborn, Rachel E AU - Sanborn RE AD - Earle A. Chiles Research Institute, Providence Cancer Institute, Portland, OR, USA. FAU - Salimi, Tehseen AU - Salimi T AD - G1 Therapeutics, Inc., Research Triangle Park, NC, USA. LA - eng PT - Journal Article PT - Observational Study PL - England TA - J Med Econ JT - Journal of medical economics JID - 9892255 RN - 0 (Antineoplastic Agents) SB - IM MH - Aged MH - *Antineoplastic Agents/therapeutic use MH - Electronics MH - Female MH - Humans MH - *Lung Neoplasms/drug therapy MH - Male MH - Quality of Life MH - Retrospective Studies MH - *Small Cell Lung Carcinoma MH - United States OAB - PLAIN LANGUAGE SUMMARYThis study looked at the medical records of people with a particular type of lung cancer known as small cell lung cancer. When treated with chemotherapy, people with this cancer may develop a condition called myelosuppression. This causes people to have fewer blood cells, which can lead to tiredness, or increase the risk of infection or bleeding. The study looked at what types of chemotherapy people with small cell lung cancer were given, what the side effects of myelosuppression were, how often the side effects were reported, and what treatments were given to manage these side effects. The study also looked at whether people with side effects from myelosuppression needed more visits to the doctor or hospital. Around 3 out of 5 people in the study experienced serious side effects resulting in reduced numbers of white blood cells (which fight infection), red blood cells (which carry oxygen), or platelets (which help the blood to clot), and many needed drugs or blood transfusions to treat these side effects. On average, people with side effects from myelosuppression had more visits to healthcare facilities than those people without these side effects. The findings suggest that myelosuppression places a large burden on people with small cell lung cancer who are treated with chemotherapy. OABL- eng OTO - NOTNLM OT - Chemotherapy OT - I OT - I00 OT - I1 OT - I11 OT - healthcare resource use OT - hematologic toxicity OT - myelosuppression OT - small cell lung cancer OT - supportive care EDAT- 2021/12/21 06:00 MHDA- 2022/01/13 06:00 CRDT- 2021/12/20 08:44 PHST- 2021/12/21 06:00 [pubmed] PHST- 2022/01/13 06:00 [medline] PHST- 2021/12/20 08:44 [entrez] AID - 10.1080/13696998.2021.2020570 [doi] PST - ppublish SO - J Med Econ. 2022 Jan-Dec;25(1):108-118. doi: 10.1080/13696998.2021.2020570.