PMID- 34929740
OWN - NLM
STAT- MEDLINE
DCOM- 20220913
LR  - 20220913
IS  - 1464-3502 (Electronic)
IS  - 0735-0414 (Linking)
VI  - 57
IP  - 5
DP  - 2022 Sep 10
TI  - Association Between Functional and Structural Brain Connectivity of the Default 
      Mode Network in Non-treatment Seeking Individuals With Alcohol Use Disorder.
PG  - 540-551
LID - 10.1093/alcalc/agab079 [doi]
AB  - AIMS: Alcohol use disorder (AUD) is associated with alterations within the 
      default mode network (DMN) at rest. Also, impaired white matter structures have 
      been observed in individuals with AUD. This study developed a workflow for 
      examining the relation between functional and structural connectivity, exemplary 
      for nodes of the DMN within a sample of non-treatment seeking individuals with 
      AUD. Furthermore, AUD severity was correlated with both measures independently. 
      METHODS: The functional magnetic resonance imaging (fMRI) protocol included 
      anatomical, resting state and diffusion weighted imaging measurements. 
      Independent component analyses and deterministic fiber tracking as well as 
      correlation analyses, including the severity of AUD, were performed. N = 18 out 
      of 23 adult study participants took part in the fMRI examination, and N = 15 were 
      included in the final analyses. RESULTS: Established resting-state networks were 
      reliably identified in our sample. Structural connections were found between 
      several nodes of the DMN, whereas only fibers between the medial prefrontal 
      cortex and the posterior cingulate cortex were reliably detected in all 
      individuals. A negative correlation was observed between brain activation during 
      rest and AUD severity in left parietal and temporal regions and the putamen. A 
      more severe AUD predicted impairments in white matter integrity of the cingulum. 
      CONCLUSION: In AUD, information obtained from a combination of resting-state, 
      diffusion weighted data and clinical information has great potential to provide a 
      more profound understanding of the disorder since alterations may already become 
      apparent at earlier stages of the disorder, e.g. in non-treatment seeking 
      individuals. SUMMARY: Alcohol use disorder leads to alterations in the default 
      mode network of the resting brain that is associated with the severity of the 
      disorder. Following our workflow, white matter impairments can be observed 
      between some of the nodes of the default mode network using diffusion tensor 
      imaging. Both, resting-state functional and structural connectivity relate to the 
      severity of alcohol use disorder.
CI  - (c) The Author(s) 2021. Medical Council on Alcohol and Oxford University Press. All 
      rights reserved.
FAU - Gerhardt, Sarah
AU  - Gerhardt S
AUID- ORCID: 0000-0001-9570-7874
AD  - Department of Addictive Behavior and Addiction Medicine, Central Institute of 
      Mental Health, Medical Faculty Mannheim, University of Heidelberg, Quadrat J 5, 
      68159 Mannheim, Germany.
FAU - Karl, Damian
AU  - Karl D
AUID- ORCID: 0000-0003-2043-3818
AD  - Department of Addictive Behavior and Addiction Medicine, Central Institute of 
      Mental Health, Medical Faculty Mannheim, University of Heidelberg, Quadrat J 5, 
      68159 Mannheim, Germany.
FAU - Mann, Karl
AU  - Mann K
AUID- ORCID: 0000-0002-2087-1976
AD  - Department of Addictive Behavior and Addiction Medicine, Central Institute of 
      Mental Health, Medical Faculty Mannheim, University of Heidelberg, Quadrat J 5, 
      68159 Mannheim, Germany.
FAU - Kiefer, Falk
AU  - Kiefer F
AUID- ORCID: 0000-0001-7213-0398
AD  - Department of Addictive Behavior and Addiction Medicine, Central Institute of 
      Mental Health, Medical Faculty Mannheim, University of Heidelberg, Quadrat J 5, 
      68159 Mannheim, Germany.
AD  - Mannheim Center for Translational Neurosciences (MCTN), Medical Faculty Mannheim, 
      University of Heidelberg, Theodor-Kutzer-Ufer 1-3, 68167 Mannheim, Germany.
AD  - Feuerlein Center on Translational Addiction Medicine, Central Institute of Mental 
      Health, Medical Faculty Mannheim, University of Heidelberg, Quadrat J 5, 68159 
      Mannheim, Germany.
FAU - Vollstadt-Klein, Sabine
AU  - Vollstadt-Klein S
AUID- ORCID: 0000-0002-6210-672X
AD  - Department of Addictive Behavior and Addiction Medicine, Central Institute of 
      Mental Health, Medical Faculty Mannheim, University of Heidelberg, Quadrat J 5, 
      68159 Mannheim, Germany.
AD  - Mannheim Center for Translational Neurosciences (MCTN), Medical Faculty Mannheim, 
      University of Heidelberg, Theodor-Kutzer-Ufer 1-3, 68167 Mannheim, Germany.
LA  - eng
GR  - GRK2350-1/Deutsche Forschungsgemeinschaft/
PT  - Journal Article
PL  - England
TA  - Alcohol Alcohol
JT  - Alcohol and alcoholism (Oxford, Oxfordshire)
JID - 8310684
SB  - IM
MH  - Adult
MH  - *Alcoholism/diagnostic imaging/pathology/therapy
MH  - Brain/diagnostic imaging
MH  - Default Mode Network
MH  - *Diffusion Tensor Imaging
MH  - Humans
MH  - Magnetic Resonance Imaging
MH  - Nerve Net/diagnostic imaging
MH  - Neural Pathways/diagnostic imaging
EDAT- 2021/12/21 06:00
MHDA- 2022/09/14 06:00
CRDT- 2021/12/20 20:34
PHST- 2020/09/15 00:00 [received]
PHST- 2021/11/04 00:00 [revised]
PHST- 2021/11/12 00:00 [accepted]
PHST- 2021/12/21 06:00 [pubmed]
PHST- 2022/09/14 06:00 [medline]
PHST- 2021/12/20 20:34 [entrez]
AID - 6470971 [pii]
AID - 10.1093/alcalc/agab079 [doi]
PST - ppublish
SO  - Alcohol Alcohol. 2022 Sep 10;57(5):540-551. doi: 10.1093/alcalc/agab079.