PMID- 34930225
OWN - NLM
STAT- MEDLINE
DCOM- 20220314
LR  - 20220531
IS  - 1472-6874 (Electronic)
IS  - 1472-6874 (Linking)
VI  - 21
IP  - 1
DP  - 2021 Dec 20
TI  - Expression levels of MCP-1, HGF, and IGF-1 in endometriotic patients compared 
      with non-endometriotic controls.
PG  - 422
LID - 10.1186/s12905-021-01560-6 [doi]
LID - 422
AB  - BACKGROUND: To study the concentrations of monocyte chemoattractant protein-1 
      (MCP-1), hepatocyte growth factor (HGF), and insulin-like growth factor-1 (IGF-1) 
      in peritoneal fluid (PF) and serum, and to evaluate their expressions by PF and 
      peripheral blood mononuclear cells (PFMCs and PBMCs, respectively), and ectopic 
      and eutopic endometrial stromal cells of patients with endometriosis (EESCs and 
      EuESCs, respectively) compared with controls. METHODS: The concentrations of 
      mentioned cytokines in serum and PF, as well as their expression in PBMCs, PFMCs, 
      EuESCs and EESCs from endometriosis patients and controls were assessed. RESULTS: 
      The levels of MCP-1, HGF, and IGF-1 in serum and PF in women with endometriosis 
      were significantly higher than the controls (P < 0.05-P < 0.001). Gene expression 
      of MCP-1 and IGF-1 in the PFMCs, PBMCs and EESCs also showed an increased level 
      compared to controls (P < 0.05-P < 0.01). The protein expression of MCP-1 and 
      IGF-1 by PFMCs was statistically higher in endometriotic women (P < 0.05 and 
      P < 0.01, respectively). The gene and protein expression of HGF in PFMCs and its 
      gene expression by EESCs were significantly higher in endometriotic women 
      compared to controls (P < 0.05-P < 0.01). CONCLUSIONS: The higher concentrations 
      of mentioned cytokines in serum and PF and their higher expression by PFMCs and 
      EESCs in endometriosis patients may contribute to the development of 
      endometriosis.
CI  - (c) 2021. The Author(s).
FAU - Heidari, Sahel
AU  - Heidari S
AD  - Immunology Research Center, Institute of Immunology and Infectious Diseases, Iran 
      University of Medical Sciences, Tehran, Iran.
AD  - Department of Immunology, School of Medicine, Iran University of Medical 
      Sciences, Tehran, Iran.
FAU - Kolahdouz-Mohammadi, Roya
AU  - Kolahdouz-Mohammadi R
AD  - Department of Nutrition, School of Public Health, Iran University of Medical 
      Sciences, Tehran, Iran.
FAU - Khodaverdi, Sepideh
AU  - Khodaverdi S
AD  - Endometriosis Research Center, Iran University of Medical Sciences, Tehran, Iran.
FAU - Tajik, Nader
AU  - Tajik N
AD  - Immunology Research Center, Institute of Immunology and Infectious Diseases, Iran 
      University of Medical Sciences, Tehran, Iran.
FAU - Delbandi, Ali-Akbar
AU  - Delbandi AA
AD  - Immunology Research Center, Institute of Immunology and Infectious Diseases, Iran 
      University of Medical Sciences, Tehran, Iran. delbandi.ak@iums.ac.ir.
AD  - Department of Immunology, School of Medicine, Iran University of Medical 
      Sciences, Tehran, Iran. delbandi.ak@iums.ac.ir.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20211220
PL  - England
TA  - BMC Womens Health
JT  - BMC women's health
JID - 101088690
RN  - 0 (CCL2 protein, human)
RN  - 0 (Chemokine CCL2)
RN  - 0 (HGF protein, human)
RN  - 0 (IGF1 protein, human)
RN  - 67256-21-7 (Hepatocyte Growth Factor)
RN  - 67763-96-6 (Insulin-Like Growth Factor I)
SB  - IM
MH  - *Chemokine CCL2/genetics/metabolism
MH  - *Endometriosis/genetics
MH  - Endometrium/metabolism
MH  - Female
MH  - *Hepatocyte Growth Factor/genetics/metabolism
MH  - Humans
MH  - *Insulin-Like Growth Factor I/genetics/metabolism
MH  - Leukocytes, Mononuclear/metabolism
PMC - PMC8686524
OTO - NOTNLM
OT  - Ectopic
OT  - Endometrial stromal cells
OT  - Endometriosis
OT  - HGF
OT  - IGF-1
OT  - MCP-1
OT  - PFMCs
COIS- The authors declare that they have no competing interests.
EDAT- 2021/12/22 06:00
MHDA- 2022/03/15 06:00
PMCR- 2021/12/20
CRDT- 2021/12/21 05:40
PHST- 2021/10/27 00:00 [received]
PHST- 2021/12/02 00:00 [accepted]
PHST- 2021/12/21 05:40 [entrez]
PHST- 2021/12/22 06:00 [pubmed]
PHST- 2022/03/15 06:00 [medline]
PHST- 2021/12/20 00:00 [pmc-release]
AID - 10.1186/s12905-021-01560-6 [pii]
AID - 1560 [pii]
AID - 10.1186/s12905-021-01560-6 [doi]
PST - epublish
SO  - BMC Womens Health. 2021 Dec 20;21(1):422. doi: 10.1186/s12905-021-01560-6.