PMID- 34931330
OWN - NLM
STAT- MEDLINE
DCOM- 20220224
LR  - 20220224
IS  - 1096-9071 (Electronic)
IS  - 0146-6615 (Linking)
VI  - 94
IP  - 4
DP  - 2022 Apr
TI  - Influence of the COVID-19 pandemic on the incidence and exacerbation of childhood 
      allergic diseases.
PG  - 1655-1669
LID - 10.1002/jmv.27536 [doi]
AB  - To explore the influence of changes in human lifestyle and the living environment 
      caused by nonpharmaceutical interventions in coronavirus disease 2019 (COVID-19) 
      on allergic diseases, the present study enrolled children who came to the 
      Children's Hospital of Zhejiang University for allergen detection between January 
      2019 and December 2020. By comparing the positive rates and levels of various 
      allergen-specific immunoglobulin E (IgE) before and during the COVID-19 pandemic, 
      the influence of changes in human lifestyle and the living environment caused by 
      prevention and control measures in COVID-19 on allergic diseases was evaluated. 
      In 2019, 41 648 allergic children went to the hospital, but in 2020, due to the 
      impact of the COVID-19 epidemic, the number decreased to 24 714. In 2020, the 
      number of allergy visits was the lowest in February and gradually increased. 
      There were 45 879 children with total IgE > 17.5 IU/ml in 2 years, accounting for 
      69.13% of the total samples, of which the proportion was 68.52% (28 536/41 648) 
      in 2019 and 70.17% (17 343/24 714) in 2020. A total of 29 906 children were 
      positive for one or more allergens in 2 years. It accounts for 45.06% of the 
      total number of samples, of which the proportion is 41.53% (17 296/41 648) in 
      2019 and 51.02% (12 610/24 714) in 2020. Except for cashew nuts, the positive 
      number of other allergens in 2020 was less than in 2019, especially after June 
      and July 2020. Except for Artemisia argyi, the positive rates of other allergens 
      in 2020 were significantly higher than those in 2019 (p < 0.05). Moreover, the 
      changing trend of the positive allergen rate in each month in 2020 was different 
      from that in 2019. In 2020, except for Dermatophagoides farinae, Dermatophagoides 
      pteronyssinus, and Crab, specific IgE levels of other allergens were not greater 
      than those in 2019 (p < 0.05). Thus it can be seen, during the COVID-19 pandemic, 
      nonpharmaceutical interventions played a protective role in reducing children's 
      exposure to allergens and alleviating allergic reactions.
CI  - (c) 2021 Wiley Periodicals LLC.
FAU - Ye, Qing
AU  - Ye Q
AUID- ORCID: 0000-0002-6756-0630
AD  - The Children's Hospital, Zhejiang University School of Medicine, National 
      Clinical Research Center for Child Health, National Children's Regional Medical 
      Center, Hangzhou, Zhejiang, China.
FAU - Wang, Bili
AU  - Wang B
AD  - The Children's Hospital, Zhejiang University School of Medicine, National 
      Clinical Research Center for Child Health, National Children's Regional Medical 
      Center, Hangzhou, Zhejiang, China.
FAU - Liu, Huihui
AU  - Liu H
AD  - The Children's Hospital, Zhejiang University School of Medicine, National 
      Clinical Research Center for Child Health, National Children's Regional Medical 
      Center, Hangzhou, Zhejiang, China.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20211230
PL  - United States
TA  - J Med Virol
JT  - Journal of medical virology
JID - 7705876
RN  - 0 (Allergens)
RN  - 37341-29-0 (Immunoglobulin E)
SB  - IM
MH  - Allergens/classification/immunology
MH  - Animals
MH  - COVID-19/*epidemiology/prevention & control
MH  - Child
MH  - Child, Preschool
MH  - China/epidemiology
MH  - Female
MH  - Humans
MH  - Hypersensitivity/blood/*epidemiology
MH  - Immunoglobulin E/blood/immunology
MH  - Incidence
MH  - Infant
MH  - Infant, Newborn
MH  - Male
MH  - SARS-CoV-2
OTO - NOTNLM
OT  - COVID-19
OT  - IgE
OT  - allergens
OT  - nonpharmaceutical interventions
EDAT- 2021/12/22 06:00
MHDA- 2022/02/25 06:00
CRDT- 2021/12/21 06:53
PHST- 2021/12/14 00:00 [revised]
PHST- 2021/11/11 00:00 [received]
PHST- 2021/12/19 00:00 [accepted]
PHST- 2021/12/22 06:00 [pubmed]
PHST- 2022/02/25 06:00 [medline]
PHST- 2021/12/21 06:53 [entrez]
AID - 10.1002/jmv.27536 [doi]
PST - ppublish
SO  - J Med Virol. 2022 Apr;94(4):1655-1669. doi: 10.1002/jmv.27536. Epub 2021 Dec 30.