PMID- 34933285
OWN - NLM
STAT- MEDLINE
DCOM- 20220201
LR  - 20220201
IS  - 2057-1976 (Electronic)
IS  - 2057-1976 (Linking)
VI  - 8
IP  - 2
DP  - 2022 Jan 5
TI  - Alterations of tibialis anterior muscle activation pattern in subjects with type 
      2 diabetes and diabetic peripheral neuropathy.
LID - 10.1088/2057-1976/ac455b [doi]
AB  - Diabetic peripheral neuropathy (DPN) is associated with loss of motor units 
      (MUs), which can cause changes in the activation pattern of muscle fibres. This 
      study investigated the pattern of muscle activation using high-density surface 
      electromyography (HD-sEMG) signals from subjects with type 2 diabetes mellitus 
      (T2DM) and DPN. Thirty-five adults participated in the study: 12 healthy subjects 
      (HV), 12 patients with T2DM without DPN (No-DPN) and 11 patients with T2DM with 
      DPN (DPN). HD-sEMG signals were recorded in the tibialis anterior muscle during 
      an isometric contraction of ankle dorsiflexion at 50% of the maximum voluntary 
      isometric contraction (MVIC) during 30-s. The calculated HD-sEMG signals 
      parameters were the normalised root mean square (RMS), normalised median 
      frequency (MDF), coefficient of variation (CoV) and modified entropy (ME). The 
      RMS increased significantly (p = 0.001) with time only for the DPN group, while 
      the MDF decreased significantly (p < 0.01) with time for the three groups. 
      Moreover, the ME was significantly lower (p = 0.005), and CoV was significantly 
      higher (p = 0.003) for the DPN group than the HV group. Using HD-sEMG, we have 
      demonstrated a reduction in the number of MU recruited by individuals with DPN. 
      This study provides proof of concept for the clinical utility of this technique 
      for identifying neuromuscular impairment caused by DPN.
CI  - (c) 2022 IOP Publishing Ltd.
FAU - Favretto, M A
AU  - Favretto MA
AUID- ORCID: 0000-0001-6923-8808
AD  - Institute of Biomedical Engineering, Department of Electrical and Electronic 
      Engineering, Federal University of Santa Catarina, Florianopolis, Santa Catarina, 
      Brazil.
FAU - Cossul, S
AU  - Cossul S
AUID- ORCID: 0000-0003-4839-9447
AD  - Institute of Biomedical Engineering, Department of Electrical and Electronic 
      Engineering, Federal University of Santa Catarina, Florianopolis, Santa Catarina, 
      Brazil.
FAU - Andreis, F R
AU  - Andreis FR
AUID- ORCID: 0000-0002-1610-992X
AD  - Center for Neuroplasticity and Pain (CNAP), Department of Health Science and 
      Technology, Aalborg University, Aalborg, Denmark.
FAU - Nakamura, L R
AU  - Nakamura LR
AUID- ORCID: 0000-0002-7312-2717
AD  - Department of Informatics and Statistics, Federal University of Santa Catarina, 
      Florianopolis, Santa Catarina, Brazil.
FAU - Ronsoni, M F
AU  - Ronsoni MF
AUID- ORCID: 0000-0003-1187-9842
AD  - Department of Endocrinology and Metabolism, University Hospital, Federal 
      University of Santa Catarina, Florianopolis, Santa Catarina, Brazil.
FAU - Tesfaye, S
AU  - Tesfaye S
AUID- ORCID: 0000-0003-1190-1472
AD  - Diabetes Research Department, Sheffield Teaching Hospitals NHS Foundation Trust, 
      Sheffield, United Kingdom.
FAU - Selvarajah, D
AU  - Selvarajah D
AUID- ORCID: 0000-0001-7426-1105
AD  - Department of Oncology and Human Metabolism, University of Sheffield, Sheffield, 
      United Kingdom.
FAU - Marques, J L B
AU  - Marques JLB
AUID- ORCID: 0000-0001-8910-4735
AD  - Institute of Biomedical Engineering, Department of Electrical and Electronic 
      Engineering, Federal University of Santa Catarina, Florianopolis, Santa Catarina, 
      Brazil.
LA  - eng
PT  - Journal Article
DEP - 20220105
PL  - England
TA  - Biomed Phys Eng Express
JT  - Biomedical physics & engineering express
JID - 101675002
SB  - IM
MH  - Adult
MH  - *Diabetes Mellitus, Type 2/complications/physiopathology
MH  - *Diabetic Neuropathies/diagnosis/physiopathology
MH  - Humans
MH  - Isometric Contraction
MH  - Muscle, Skeletal/*physiopathology
OTO - NOTNLM
OT  - diabetic neuropathies
OT  - high-density surface electromyography
OT  - motor unit
OT  - motor unit recruitment
OT  - tibialis anterior muscle
EDAT- 2021/12/22 06:00
MHDA- 2022/02/02 06:00
CRDT- 2021/12/21 20:26
PHST- 2021/06/26 00:00 [received]
PHST- 2021/12/21 00:00 [accepted]
PHST- 2021/12/22 06:00 [pubmed]
PHST- 2022/02/02 06:00 [medline]
PHST- 2021/12/21 20:26 [entrez]
AID - 10.1088/2057-1976/ac455b [doi]
PST - epublish
SO  - Biomed Phys Eng Express. 2022 Jan 5;8(2). doi: 10.1088/2057-1976/ac455b.