PMID- 34935026
OWN - NLM
STAT- MEDLINE
DCOM- 20220307
LR  - 20240226
IS  - 2050-7518 (Electronic)
IS  - 2050-750X (Linking)
VI  - 10
IP  - 2
DP  - 2022 Jan 5
TI  - PLGA-collagen-BPNS Bifunctional composite mesh for photothermal therapy of 
      melanoma and skin tissue engineering.
PG  - 204-213
LID - 10.1039/d1tb02366g [doi]
AB  - The treatment of melanoma requires not only the elimination of skin cancer cells 
      but also skin regeneration to heal defects. To achieve this goal, a bifunctional 
      composite scaffold of poly(DL-lactic-co-glycolic acid) (PLGA), collagen and black 
      phosphorus nanosheets (BPNSs) was prepared by hybridizing a BPNS-embedded 
      collagen sponge with a PLGA knitted mesh. The composite mesh increased the 
      temperature under near-infrared laser irradiation. The incorporation of BPNSs 
      provided the PLGA-collagen-BPNS composite mesh with excellent photothermal 
      properties for the photothermal ablation of melanoma cells both in vitro and in 
      vivo. The PLGA-collagen-BPNS composite mesh had high mechanical strength for easy 
      handling. The PLGA-collagen-BPNS composite mesh facilitated the proliferation of 
      fibroblasts, promoted the expression of angiogenesis-related genes and the genes 
      of components of the extracellular matrix for skin tissue regeneration. The high 
      mechanical strength, photothermal ablation capability and skin tissue 
      regeneration effects demonstrate that the bifunctional PLGA-collagen-BPNS 
      composite mesh is a versatile and effective platform for the treatment of 
      melanoma and the regeneration of skin defects.
FAU - Sutrisno, Linawati
AU  - Sutrisno L
AUID- ORCID: 0000-0003-3085-9660
AD  - Research Center for Functional Materials, National Institute for Materials 
      Science, 1-1 Namiki, Tsukuba, Ibaraki, 305-0044, Japan. Guoping.CHEN@nims.go.jp.
AD  - Department of Materials Science and Engineering, Graduate School of Pure and 
      Applied Sciences, University of Tsukuba, 1-1-1 Tennodai, Tsukuba, Ibaraki, 
      305-8577, Japan.
FAU - Chen, Huajian
AU  - Chen H
AD  - Research Center for Functional Materials, National Institute for Materials 
      Science, 1-1 Namiki, Tsukuba, Ibaraki, 305-0044, Japan. Guoping.CHEN@nims.go.jp.
AD  - Department of Materials Science and Engineering, Graduate School of Pure and 
      Applied Sciences, University of Tsukuba, 1-1-1 Tennodai, Tsukuba, Ibaraki, 
      305-8577, Japan.
FAU - Yoshitomi, Toru
AU  - Yoshitomi T
AUID- ORCID: 0000-0003-3847-1812
AD  - Research Center for Functional Materials, National Institute for Materials 
      Science, 1-1 Namiki, Tsukuba, Ibaraki, 305-0044, Japan. Guoping.CHEN@nims.go.jp.
FAU - Kawazoe, Naoki
AU  - Kawazoe N
AD  - Research Center for Functional Materials, National Institute for Materials 
      Science, 1-1 Namiki, Tsukuba, Ibaraki, 305-0044, Japan. Guoping.CHEN@nims.go.jp.
FAU - Yang, Yingnan
AU  - Yang Y
AD  - Graduate School of Life and Environmental Science, University of Tsukuba, 1-1-1 
      Tennodai, Tsukuba, Ibaraki, 305-8572, Japan.
FAU - Chen, Guoping
AU  - Chen G
AUID- ORCID: 0000-0001-6753-3678
AD  - Research Center for Functional Materials, National Institute for Materials 
      Science, 1-1 Namiki, Tsukuba, Ibaraki, 305-0044, Japan. Guoping.CHEN@nims.go.jp.
AD  - Department of Materials Science and Engineering, Graduate School of Pure and 
      Applied Sciences, University of Tsukuba, 1-1-1 Tennodai, Tsukuba, Ibaraki, 
      305-8577, Japan.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20220105
PL  - England
TA  - J Mater Chem B
JT  - Journal of materials chemistry. B
JID - 101598493
RN  - 0 (Antineoplastic Agents)
RN  - 1SIA8062RS (Polylactic Acid-Polyglycolic Acid Copolymer)
RN  - 27YLU75U4W (Phosphorus)
RN  - 9007-34-5 (Collagen)
SB  - IM
MH  - Animals
MH  - Antineoplastic Agents/chemistry/radiation effects/*therapeutic use
MH  - Cell Line, Tumor
MH  - Collagen/chemistry
MH  - Female
MH  - Humans
MH  - Infrared Rays
MH  - Melanoma/*drug therapy
MH  - Mice, Inbred BALB C
MH  - Mice, Nude
MH  - Nanostructures/chemistry/radiation effects/therapeutic use
MH  - Phosphorus/chemistry/radiation effects/*therapeutic use
MH  - Photothermal Therapy/methods
MH  - Polylactic Acid-Polyglycolic Acid Copolymer/chemistry
MH  - Regeneration/*drug effects
MH  - Skin Physiological Phenomena/*drug effects
MH  - Tissue Engineering/methods
MH  - Tissue Scaffolds/*chemistry
MH  - Mice
EDAT- 2021/12/23 06:00
MHDA- 2022/03/08 06:00
CRDT- 2021/12/22 06:57
PHST- 2021/12/23 06:00 [pubmed]
PHST- 2022/03/08 06:00 [medline]
PHST- 2021/12/22 06:57 [entrez]
AID - 10.1039/d1tb02366g [doi]
PST - epublish
SO  - J Mater Chem B. 2022 Jan 5;10(2):204-213. doi: 10.1039/d1tb02366g.