PMID- 34935072 OWN - NLM STAT- MEDLINE DCOM- 20220822 LR - 20220822 IS - 1433-8491 (Electronic) IS - 0940-1334 (Print) IS - 0940-1334 (Linking) VI - 272 IP - 6 DP - 2022 Sep TI - Cognitive and functional deficits are associated with white matter abnormalities in two independent cohorts of patients with schizophrenia. PG - 957-969 LID - 10.1007/s00406-021-01363-8 [doi] AB - BACKGROUND: Significant evidence links white matter (WM) microstructural abnormalities to cognitive impairment in schizophrenia (SZ), but the relationship of these abnormalities with functional outcome remains unclear. METHODS: In two independent cohorts (C1, C2), patients with SZ were divided into two subgroups: patients with higher cognitive performance (SZ-HCP-C1, n = 25; SZ-HCP-C2, n = 24) and patients with lower cognitive performance (SZ-LCP-C1, n = 25; SZ-LCP-C2, n = 24). Healthy controls (HC) were included in both cohorts (HC-C1, n = 52; HC-C2, n = 27). We compared fractional anisotropy (FA) of the whole-brain WM skeleton between the three groups (SZ-LCP, SZ-HCP, HC) by a whole-brain exploratory approach and an atlas-defined WM regions-of-interest approach via tract-based spatial statistics. In addition, we explored whether FA values were associated with Global Assessment of Functioning (GAF) scores in the SZ groups. RESULTS: In both cohorts, mean FA values of whole-brain WM skeleton were significantly lower in the SCZ-LCP group than in the SCZ-HCP group. Whereas in C1 the FA of the frontal part of the left inferior fronto-occipital fasciculus (IFOF) was positively correlated with GAF score, in C2 the FA of the temporal part of the left IFOF was positively correlated with GAF score. CONCLUSIONS: We provide robust evidence for WM microstructural abnormalities in SZ. These abnormalities are more prominent in patients with low cognitive performance and are associated with the level of functioning. CI - (c) 2021. The Author(s). FAU - Yamada, Shinichi AU - Yamada S AD - Department of Psychiatry and Psychotherapy, University Hospital, LMU Munich, Munich, Germany. AD - Department of Neuropsychiatry, Wakayama Medical University, Wakayama, Japan. FAU - Takahashi, Shun AU - Takahashi S AD - Department of Psychiatry and Psychotherapy, University Hospital, LMU Munich, Munich, Germany. AD - Department of Neuropsychiatry, Wakayama Medical University, Wakayama, Japan. AD - Clinical Research and Education Center, Asakayama General Hospital, Sakai, Japan. FAU - Malchow, Berend AU - Malchow B AD - Department of Psychiatry and Psychotherapy, University Hospital, LMU Munich, Munich, Germany. AD - Department of Psychiatry and Psychotherapy, University Medical Center Gottingen, Gottingen, Germany. FAU - Papazova, Irina AU - Papazova I AD - Department of Psychiatry Psychotherapy and Psychosomatics, Medical Faculty, University of Augsburg, Augsburg, Germany. FAU - Stocklein, Sophia AU - Stocklein S AD - Department of Radiology, University Hospital, LMU Munich, Munich, Germany. FAU - Ertl-Wagner, Birgit AU - Ertl-Wagner B AD - Division of Neuroradiology, Department of Diagnostic Imaging, The Hospital for Sick Children, Toronto, Canada. FAU - Papazov, Boris AU - Papazov B AD - Department of Radiology, University Hospital, LMU Munich, Munich, Germany. FAU - Kumpf, Ulrike AU - Kumpf U AD - Department of Psychiatry and Psychotherapy, University Hospital, LMU Munich, Munich, Germany. FAU - Wobrock, Thomas AU - Wobrock T AD - Department of Psychiatry and Psychotherapy, University Medical Center Gottingen, Gottingen, Germany. AD - Department of Psychiatry and Psychotherapy, County Hospitals Darmstadt-Dieburg, Gross-Umstadt, Germany. FAU - Keller-Varady, Katriona AU - Keller-Varady K AD - Institute of Sports Medicine, Hannover Medical School, Hannover, Germany. FAU - Hasan, Alkomiet AU - Hasan A AD - Department of Psychiatry Psychotherapy and Psychosomatics, Medical Faculty, University of Augsburg, Augsburg, Germany. FAU - Falkai, Peter AU - Falkai P AD - Department of Psychiatry and Psychotherapy, University Hospital, LMU Munich, Munich, Germany. FAU - Wagner, Elias AU - Wagner E AD - Department of Psychiatry and Psychotherapy, University Hospital, LMU Munich, Munich, Germany. FAU - Raabe, Florian J AU - Raabe FJ AUID- ORCID: 0000-0001-8538-0783 AD - Department of Psychiatry and Psychotherapy, University Hospital, LMU Munich, Munich, Germany. florian.raabe@med.uni-muenchen.de. AD - International Max Planck Research School for Translational Psychiatry (IMPRS-TP), Munich, Germany. florian.raabe@med.uni-muenchen.de. FAU - Keeser, Daniel AU - Keeser D AD - Department of Psychiatry and Psychotherapy, University Hospital, LMU Munich, Munich, Germany. daniel.keeser@med.uni-muenchen.de. AD - Department of Radiology, University Hospital, LMU Munich, Munich, Germany. daniel.keeser@med.uni-muenchen.de. AD - NeuroImaging Core Unit Munich (NICUM), University Hospital, LMU Munich, Munich, Germany. daniel.keeser@med.uni-muenchen.de. LA - eng PT - Journal Article DEP - 20211221 PL - Germany TA - Eur Arch Psychiatry Clin Neurosci JT - European archives of psychiatry and clinical neuroscience JID - 9103030 SB - IM MH - Anisotropy MH - Brain/diagnostic imaging MH - Cognition MH - Diffusion Tensor Imaging MH - Humans MH - *Schizophrenia/complications/diagnostic imaging MH - *White Matter/diagnostic imaging PMC - PMC9388472 OTO - NOTNLM OT - Cognitive deficits OT - Confirmation OT - Fractional anisotropy OT - Global functioning OT - Replication OT - Schizophrenia COIS- The authors declare that they have no conflict of interest. EDAT- 2021/12/23 06:00 MHDA- 2022/08/23 06:00 PMCR- 2021/12/21 CRDT- 2021/12/22 07:00 PHST- 2021/09/06 00:00 [received] PHST- 2021/11/24 00:00 [accepted] PHST- 2021/12/23 06:00 [pubmed] PHST- 2022/08/23 06:00 [medline] PHST- 2021/12/22 07:00 [entrez] PHST- 2021/12/21 00:00 [pmc-release] AID - 10.1007/s00406-021-01363-8 [pii] AID - 1363 [pii] AID - 10.1007/s00406-021-01363-8 [doi] PST - ppublish SO - Eur Arch Psychiatry Clin Neurosci. 2022 Sep;272(6):957-969. doi: 10.1007/s00406-021-01363-8. Epub 2021 Dec 21.