PMID- 34936855
OWN - NLM
STAT- MEDLINE
DCOM- 20221004
LR  - 20221004
IS  - 1502-4725 (Electronic)
IS  - 0803-9488 (Linking)
VI  - 76
IP  - 7
DP  - 2022 Oct
TI  - Longitudinal persistence of negative symptoms in young individuals with first 
      episode schizophrenia: a 24-month multi-modal program follow-up.
PG  - 530-538
LID - 10.1080/08039488.2021.2015431 [doi]
AB  - PURPOSE: Persistent Negative Symptoms (PNS) affect real-world functioning already 
      at the onset of schizophrenia. Longitudinal studies on beneficial effects of 
      psychosocial treatments for PNS in First Episode Schizophrenia (FES) are still 
      relatively scarce. The aim of the current study was to evaluate the longitudinal 
      persistence of PNS in young FES individuals treated according to the multimodal 
      "Early Intervention in Psychosis" (EIP) program over a 2-year follow-up period. 
      MATERIALS AND METHODS: 133 FES subjects (aged 12-35 years) were recruited within 
      the Italian EIP program and completed the Positive And Negative Syndrome Scale 
      (PANSS) and the Global Assessment of Functioning (GAF). In accordance with the 
      PNS criteria, we dichotomized FES individuals with and without PNS. In the FES 
      group with PNS, a multiple linear regression analysis was conducted to examine 
      relevant associations between longitudinal PNS levels and the specialized 
      treatment components of our EIP protocol. RESULTS: Twenty (15%) FES participants 
      met the PNS criteria. At baseline, PNS levels had relevant positive correlations 
      with functioning decline and PANSS total score. At the end, the 2-years follow-up 
      period, FES subjects with PNS showed a significant decrease in PNS levels. In our 
      linear regression analysis, this reduction was associated with a higher number of 
      individual psychotherapy and case management sessions delivered during our 
      follow-up (together with a shorter DUP [Duration of Untreated Psychosis]). 
      CONCLUSIONS: PNS are clinically relevant in a minority of FES individuals. Our 
      results suggest that patient-tailored psychosocial interventions can reduce 
      clinical severity of PNS over a 2-year period.
FAU - Pelizza, Lorenzo
AU  - Pelizza L
AUID- ORCID: 0000-0003-4746-2061
AD  - Department of Mental Health and Pathological Addiction, Azienda USL di Parma, 
      Parma, Italy.
FAU - Leuci, Emanuela
AU  - Leuci E
AD  - Department of Mental Health and Pathological Addiction, Azienda USL di Parma, 
      Parma, Italy.
FAU - Maestri, Davide
AU  - Maestri D
AD  - Department of Mental Health and Pathological Addiction, Azienda USL di Parma, 
      Parma, Italy.
FAU - Quattrone, Emanuela
AU  - Quattrone E
AD  - Department of Mental Health and Pathological Addiction, Azienda USL di Parma, 
      Parma, Italy.
FAU - Azzali, Silvia
AU  - Azzali S
AD  - Department of Mental Health and Pathological Addiction, Azienda USL-IRCCS di 
      Reggio Emilia, Reggio Emilia, Italy.
FAU - Paulillo, Giuseppina
AU  - Paulillo G
AD  - Department of Mental Health and Pathological Addiction, Azienda USL di Parma, 
      Parma, Italy.
FAU - Pellegrini, Pietro
AU  - Pellegrini P
AD  - Department of Mental Health and Pathological Addiction, Azienda USL di Parma, 
      Parma, Italy.
LA  - eng
PT  - Journal Article
DEP - 20211222
PL  - England
TA  - Nord J Psychiatry
JT  - Nordic journal of psychiatry
JID - 100927567
SB  - IM
MH  - Follow-Up Studies
MH  - Humans
MH  - Longitudinal Studies
MH  - *Psychotic Disorders/diagnosis
MH  - *Schizophrenia/diagnosis
MH  - Schizophrenic Psychology
OTO - NOTNLM
OT  - Persistent negative symptoms
OT  - early intervention
OT  - early schizophrenia
OT  - first episode schizophrenia
OT  - follow-up
OT  - treatment response
EDAT- 2021/12/23 06:00
MHDA- 2022/10/05 06:00
CRDT- 2021/12/22 20:09
PHST- 2021/12/23 06:00 [pubmed]
PHST- 2022/10/05 06:00 [medline]
PHST- 2021/12/22 20:09 [entrez]
AID - 10.1080/08039488.2021.2015431 [doi]
PST - ppublish
SO  - Nord J Psychiatry. 2022 Oct;76(7):530-538. doi: 10.1080/08039488.2021.2015431. 
      Epub 2021 Dec 22.