PMID- 34937434
OWN - NLM
STAT- MEDLINE
DCOM- 20220602
LR  - 20220727
IS  - 1549-7798 (Electronic)
IS  - 1040-9238 (Linking)
VI  - 57
IP  - 3
DP  - 2022 Jun
TI  - Unraveling the complex regulatory networks in biofilm formation in bacteria and 
      relevance of biofilms in environmental remediation.
PG  - 305-332
LID - 10.1080/10409238.2021.2015747 [doi]
AB  - Biofilms are assemblages of bacteria embedded within a matrix of extracellular 
      polymeric substances (EPS) attached to a substratum. The process of biofilm 
      formation is a complex phenomenon regulated by the intracellular and 
      intercellular signaling systems. Various secondary messenger molecules such as 
      cyclic dimeric guanosine 3',5'-monophosphate (c-di-GMP), cyclic adenosine 
      3',5'-monophosphate (cAMP), and cyclic dimeric adenosine 3',5'-monophosphate 
      (c-di-AMP) are involved in complex signaling networks to regulate biofilm 
      development in several bacteria. Moreover, the cell to cell communication system 
      known as Quorum Sensing (QS) also regulates biofilm formation via diverse 
      mechanisms in various bacterial species. Bacteria often switch to the biofilm 
      lifestyle in the presence of toxic pollutants to improve their survivability. 
      Bacteria within a biofilm possess several advantages with regard to the 
      degradation of harmful pollutants, such as increased protection within the 
      biofilm to resist the toxic pollutants, synthesis of extracellular polymeric 
      substances (EPS) that helps in the sequestration of pollutants, elevated 
      catabolic gene expression within the biofilm microenvironment, higher cell 
      density possessing a large pool of genetic resources, adhesion ability to a wide 
      range of substrata, and metabolic heterogeneity. Therefore, a comprehensive 
      account of the various factors regulating biofilm development would provide 
      valuable insights to modulate biofilm formation for improved bioremediation 
      practices. This review summarizes the complex regulatory networks that influence 
      biofilm development in bacteria, with a major focus on the applications of 
      bacterial biofilms for environmental restoration.
FAU - Mahto, Kumari Uma
AU  - Mahto KU
AD  - Department of Life Science, Laboratory of Environmental Microbiology and Ecology 
      (LEnME), National Institute of Technology, Odisha, India.
FAU - Kumari, Swetambari
AU  - Kumari S
AD  - Department of Life Science, Laboratory of Environmental Microbiology and Ecology 
      (LEnME), National Institute of Technology, Odisha, India.
FAU - Das, Surajit
AU  - Das S
AD  - Department of Life Science, Laboratory of Environmental Microbiology and Ecology 
      (LEnME), National Institute of Technology, Odisha, India.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20211222
PL  - England
TA  - Crit Rev Biochem Mol Biol
JT  - Critical reviews in biochemistry and molecular biology
JID - 8903774
RN  - 0 (Bacterial Proteins)
RN  - 0 (Environmental Pollutants)
RN  - K72T3FS567 (Adenosine)
SB  - IM
MH  - Adenosine/metabolism
MH  - Bacteria/metabolism
MH  - *Bacterial Proteins/metabolism
MH  - Biodegradation, Environmental
MH  - Biofilms
MH  - *Environmental Pollutants/metabolism/toxicity
MH  - Gene Expression Regulation, Bacterial
OTO - NOTNLM
OT  - Biofilm
OT  - EPS
OT  - bioremediation
OT  - quorum sensing
OT  - secondary messengers
EDAT- 2021/12/24 06:00
MHDA- 2022/06/03 06:00
CRDT- 2021/12/23 05:22
PHST- 2021/12/24 06:00 [pubmed]
PHST- 2022/06/03 06:00 [medline]
PHST- 2021/12/23 05:22 [entrez]
AID - 10.1080/10409238.2021.2015747 [doi]
PST - ppublish
SO  - Crit Rev Biochem Mol Biol. 2022 Jun;57(3):305-332. doi: 
      10.1080/10409238.2021.2015747. Epub 2021 Dec 22.