PMID- 34938287
OWN - NLM
STAT- MEDLINE
DCOM- 20220106
LR  - 20220106
IS  - 1664-3224 (Electronic)
IS  - 1664-3224 (Linking)
VI  - 12
DP  - 2021
TI  - The Impact of Age Difference on the Efficacy and Safety of COVID-19 Vaccines: A 
      Systematic Review and Meta-Analysis.
PG  - 758294
LID - 10.3389/fimmu.2021.758294 [doi]
LID - 758294
AB  - OBJECTIVE: This meta-analysis compared the efficacy and safety of five kinds of 
      COVID-19 vaccines in different age groups (young adults and older adults), aiming 
      to analyze the difference of adverse events (AEs) rate and virus geometric mean 
      titer (GMT) values between young and older people, in order to find a specific 
      trend, and explore the causes of this trend through meta-analysis. METHOD: 
      Meta-analysis was used to analyze the five eligible articles. The modified Jadad 
      scoring scale was used to evaluate the quality of eligible literature with a 
      scoring system of 1 to 7. The primary endpoint of the effectiveness index was 
      GMT. The primary endpoints of the safety index were the incidence of local AEs 
      and systemic AEs. Stata 12.0 software was used for meta-analysis. Revman 5.0 
      software was used to map the risk of publication bias, and Egger's test was used 
      to analyze publication bias. RESULTS: The GMT values of young adults were higher 
      than older adults (SMD = 1.40, 95% CI (0.79, 2.02), P<0.01). There was a higher 
      incidence of local and systemic AEs in young people than in the elderly (OR = 
      1.10, 95% CI (1.08, 1.12), P<0.01; OR = 1.18, 95% CI (1.14, 1.22), P<0.01). 
      CONCLUSION: The immune effect of young people after being vaccinated with 
      COVID-19 vaccines was better than that of the elderly, but the safety was worse 
      than that of old people, the most common AEs were fever, rash, and local muscle 
      pain, which were tolerable for young people. As the AEs of the elderly were 
      lower, they can also be vaccinated safely; the reason for the low level of GMT in 
      the elderly was related to Immunosenescence. The vaccine tolerance of people of 
      different ages needs to be studied continuously.
CI  - Copyright (c) 2021 Wang, Tong, Li, Li and Li.
FAU - Wang, Jiting
AU  - Wang J
AD  - Department of Pharmacy, The Affiliated Hospital of Southwest Medical University, 
      Luzhou, China.
AD  - Department of Pharmacy, Southwest Medical University, Luzhou, China.
FAU - Tong, Yue
AU  - Tong Y
AD  - Department of Pharmaceutical Chemistry, Southwest Medical University, Luzhou, 
      China.
FAU - Li, Duo
AU  - Li D
AD  - Department of Respiration, The Affiliated Hospital of Southwest Medical 
      University, Luzhou, China.
FAU - Li, Jun
AU  - Li J
AD  - Department of Traditional Chinese Medicine, The Affiliated Hospital of Southwest 
      Medical University, Luzhou, China.
FAU - Li, Yaling
AU  - Li Y
AD  - Department of Pharmacy, The Affiliated Hospital of Southwest Medical University, 
      Luzhou, China.
LA  - eng
PT  - Journal Article
PT  - Meta-Analysis
PT  - Research Support, Non-U.S. Gov't
PT  - Systematic Review
DEP - 20211206
PL  - Switzerland
TA  - Front Immunol
JT  - Frontiers in immunology
JID - 101560960
RN  - 0 (Antibodies, Neutralizing)
RN  - 0 (Antibodies, Viral)
RN  - 0 (COVID-19 Vaccines)
SB  - IM
MH  - Adult
MH  - Age Factors
MH  - Aged
MH  - Aged, 80 and over
MH  - Antibodies, Neutralizing/blood
MH  - Antibodies, Viral/*blood
MH  - COVID-19/*prevention & control
MH  - COVID-19 Vaccines/*adverse effects/*immunology
MH  - Female
MH  - Humans
MH  - *Immunogenicity, Vaccine
MH  - Male
MH  - Middle Aged
MH  - SARS-CoV-2
PMC - PMC8685545
OTO - NOTNLM
OT  - COVID-19 vaccines
OT  - age
OT  - double-blind
OT  - efficacy and safety
OT  - meta-analysis
OT  - randomized-controlled trials (RCT)
COIS- The authors declare that the research was conducted in the absence of any 
      commercial or financial relationships that could be construed as a potential 
      conflict of interest.
EDAT- 2021/12/24 06:00
MHDA- 2022/01/07 06:00
PMCR- 2021/12/06
CRDT- 2021/12/23 05:48
PHST- 2021/08/13 00:00 [received]
PHST- 2021/11/12 00:00 [accepted]
PHST- 2021/12/23 05:48 [entrez]
PHST- 2021/12/24 06:00 [pubmed]
PHST- 2022/01/07 06:00 [medline]
PHST- 2021/12/06 00:00 [pmc-release]
AID - 10.3389/fimmu.2021.758294 [doi]
PST - epublish
SO  - Front Immunol. 2021 Dec 6;12:758294. doi: 10.3389/fimmu.2021.758294. eCollection 
      2021.