PMID- 34938816
OWN - NLM
STAT- MEDLINE
DCOM- 20220314
LR  - 20220314
IS  - 2314-7156 (Electronic)
IS  - 2314-8861 (Print)
IS  - 2314-7156 (Linking)
VI  - 2021
DP  - 2021
TI  - Neutrophils Promote Larynx Squamous Cell Carcinoma Progression via Activating the 
      IL-17/JAK/STAT3 Pathway.
PG  - 8078646
LID - 10.1155/2021/8078646 [doi]
LID - 8078646
AB  - Laryngeal squamous cell carcinoma (LSCC) is the main type of laryngeal cancer 
      with poor prognosis. Incidence of LSCC increases every year, posing a great 
      threat to human health. The underlying mechanism needs further study. Neutrophils 
      are the most prevalent type of immune cells, which play vital roles in crosstalk 
      between the microenvironment and cancer cells. In our study, we aim to figure out 
      the complex regulation between neutrophils and LSCC. Our experiments showed that 
      LSCC cells could promote the activation and mobility of neutrophils. And, in 
      return, neutrophils enhanced the proliferation, migration, and invasion of LSCC. 
      The subsequent results showed that IL-17 was highly expressed in neutrophil 
      conditioned medium. Block of IL-17 could effectively inhibit the progression of 
      LSCC induced by neutrophils. What is more, the results showed that IL-17 
      activated the JAK/STAT3 pathway in LSCC. Inhibition of the JAK/STAT3 pathway 
      could significantly block neutrophil-induced LSCC progression. Our research 
      reveals the complex interaction between neutrophils and LSCC cells, providing new 
      ideas for the treatment of LSCC.
CI  - Copyright (c) 2021 Tianyi Liu et al.
FAU - Liu, Tianyi
AU  - Liu T
AD  - Department of Otorhinolaryngology, Renmin Hospital of Wuhan University, Wuhan, 
      430060 Hubei, China.
FAU - Zong, Shimin
AU  - Zong S
AD  - Department of Otorhinolaryngology, Union Hospital, Tongji Medical College, 
      Huazhong University of Science and Technology, Wuhan 430022, China.
FAU - Jiang, Yang
AU  - Jiang Y
AD  - Department of Otorhinolaryngology, Renmin Hospital of Wuhan University, Wuhan, 
      430060 Hubei, China.
FAU - Zhao, Rui
AU  - Zhao R
AD  - Department of Otorhinolaryngology, Renmin Hospital of Wuhan University, Wuhan, 
      430060 Hubei, China.
FAU - Wang, Jie
AU  - Wang J
AD  - Department of Otorhinolaryngology, Renmin Hospital of Wuhan University, Wuhan, 
      430060 Hubei, China.
FAU - Hua, Qingquan
AU  - Hua Q
AUID- ORCID: 0000-0003-2687-7356
AD  - Department of Otorhinolaryngology, Renmin Hospital of Wuhan University, Wuhan, 
      430060 Hubei, China.
LA  - eng
PT  - Journal Article
DEP - 20211213
PL  - Egypt
TA  - J Immunol Res
JT  - Journal of immunology research
JID - 101627166
RN  - 0 (Cytokines)
RN  - 0 (IL17A protein, human)
RN  - 0 (Interleukin-17)
RN  - 0 (STAT3 Transcription Factor)
RN  - 0 (STAT3 protein, human)
RN  - EC 2.7.10.2 (Janus Kinases)
SB  - IM
MH  - Carcinoma, Squamous Cell/etiology/*metabolism/*pathology
MH  - Cell Line, Tumor
MH  - Cell Movement/genetics/immunology
MH  - Cytokines/metabolism
MH  - Humans
MH  - Interleukin-17/*metabolism
MH  - Janus Kinases/*metabolism
MH  - Laryngeal Neoplasms/etiology/*metabolism/*pathology
MH  - Neutrophil Activation/genetics/immunology
MH  - Neutrophils/immunology/*metabolism
MH  - STAT3 Transcription Factor/*metabolism
MH  - Signal Transduction
MH  - Tumor Microenvironment
PMC - PMC8687822
COIS- The authors confirmed that there was no conflict of interest.
EDAT- 2021/12/24 06:00
MHDA- 2022/03/15 06:00
PMCR- 2021/12/13
CRDT- 2021/12/23 05:53
PHST- 2021/08/13 00:00 [received]
PHST- 2021/10/20 00:00 [revised]
PHST- 2021/11/03 00:00 [accepted]
PHST- 2021/12/23 05:53 [entrez]
PHST- 2021/12/24 06:00 [pubmed]
PHST- 2022/03/15 06:00 [medline]
PHST- 2021/12/13 00:00 [pmc-release]
AID - 10.1155/2021/8078646 [doi]
PST - epublish
SO  - J Immunol Res. 2021 Dec 13;2021:8078646. doi: 10.1155/2021/8078646. eCollection 
      2021.