PMID- 34939617
OWN - NLM
STAT- MEDLINE
DCOM- 20211224
LR  - 20240405
IS  - 0025-7818 (Print)
IS  - 2532-1080 (Electronic)
IS  - 0025-7818 (Linking)
VI  - 112
IP  - 6
DP  - 2021 Dec 23
TI  - Side effects among healthcare workers from a large Milan university hospital 
      after second dose of BNT162b2 mRNA COVID-19 vaccine.
PG  - 477-485
LID - 10.23749/mdl.v112i6.12507 [doi]
AB  - BACKGROUND: In Italy, healthcare workers (HCWs) were among the first to receive 
      COVID-19 vaccination. Aim of the present study is to evaluate frequency and 
      severity of adverse events (AEs) following the second dose of BNT162b2 vaccine 
      among HCWs of a large university hospital in Milan, Italy. METHODS: One month 
      after having received the second dose of vaccine, HCWs filled-in a form about 
      type, severity, and duration of post-vaccination local and systemic symptoms. We 
      calculated the overall frequency of AEs and used multivariable Poisson regression 
      models (adjusted for sex, age, BMI, smoking, allergy history, previous SARS-CoV-2 
      infection, anti-hypertensive therapy, and occupation) to calculate risk ratios 
      (RR) and 95% confidence intervals (CI) of AEs according to selected variables. 
      RESULTS: We included 3659 HCWs. Overall, 2801 (76.6%) experienced at least one 
      local event, with pain at injection site being the most frequent (2788, 76.2%). 
      Systemic events were reported by 2080 (56.8%) HCWs, with fatigue (52.3%), muscle 
      pain (42.2%), headache (37.7%), joint pain (31.9%), and fever (26.2%) being the 
      most frequent. Risks of systemic events were associated with female gender 
      (RR=1.14, CI: 1.06-1.23), age (strong decrease with increasing age, 
      p-trend<0.001), allergy history (RR=1.13, CI: 1.05-1.20), and current smoking 
      (RR=0.90, CI: 0.84-0.97). HCWs with previous SARS-CoV-2 infection (even if 
      symptomatic) were not at increased risk. CONCLUSIONS: Both local and systemic 
      acute effects after second dose of BNT162b2 vaccine were frequently reported. 
      However, symptoms were mostly light/mild and of short duration. Thus, our 
      findings support the safety of COVID-19 vaccination in adults in relatively good 
      health.
FAU - Borroni, Elisa
AU  - Borroni E
AD  - Department of Clinical Sciences and Community Health, University of Milan, Milan, 
      Italy. elisa.borroni@unimi.it.
FAU - Consonni, Dario
AU  - Consonni D
AD  - Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy. 
      dario.consonni@unimi.it.
FAU - Cugno, Massimo
AU  - Cugno M
AD  - Department of Pathophysiology and Transplantation, University of Milan, Milan, 
      Italy. massimo.cugno@unimi.it.
FAU - Lombardi, Andrea
AU  - Lombardi A
AD  - Department of Pathophysiology and Transplantation, University of Milan, Milan, 
      Italy. andrea.lombardi@policlinico.mi.it.
FAU - Mangioni, Davide
AU  - Mangioni D
AD  - Department of Pathophysiology and Transplantation, University of Milan, Milan, 
      Italy. davide.mangioni@unimi.it.
FAU - Bono, Patrizia
AU  - Bono P
AD  - Clinical Laboratory, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, 
      Milan, Italy. patrizia.bono@policlinico.mi.it.
FAU - Oggioni, Massimo
AU  - Oggioni M
AD  - Clinical Laboratory, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, 
      Milan, Italy. massimo.oggioni@policlinico.mi.it.
FAU - Uceda Renteria, Sara
AU  - Uceda Renteria S
AD  - Clinical Laboratory, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, 
      Milan, Italy. sara.ucedarenteria@policlinico.mi.it.
FAU - Bordini, Lorenzo
AU  - Bordini L
AD  - Occupational Health Unit, Fondazione IRCCS Ca' Granda Ospedale Maggiore 
      Policlinico, Milan, Italy. lorenzo.bordini@policlinico.mi.it.
FAU - Nava, Carlo Domenico
AU  - Nava CD
AD  - Occupational Health Unit, Fondazione IRCCS Ca' Granda Ospedale Maggiore 
      Policlinico, Milan, Italy. carlo.nava@policlinico.mi.it.
FAU - Letzgus, Matteo
AU  - Letzgus M
AD  - Medical Direction, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, 
      Milan, Italy. matteo.letzgus@policlinico.mi.it.
FAU - Gentiloni Silverj, Flaminia
AU  - Gentiloni Silverj F
AD  - Medical Direction, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, 
      Milan, Italy. flaminia.gentiloni@policlinico.mi.it.
FAU - Castaldi, Silvana
AU  - Castaldi S
AD  - Department of Biomedical Sciences for Health, University of Milan, Milan, Italy. 
      silvana.castaldi@policlinico.mi.it.
FAU - Rognoni, Magda
AU  - Rognoni M
AD  - Epidemiology Unit, ATS Brianza, Monza, Italy. magda.rognoni@ats-brianza.it.
FAU - Cavallieri D'Oro, Luca
AU  - Cavallieri D'Oro L
AD  - Epidemiology Unit, ATS Brianza, Monza, Italy. luca.cavalieridoro@ats-brianza.it.
FAU - Carugno, Michele
AU  - Carugno M
AD  - Department of Clinical Sciences and Community Health, University of Milan, Milan, 
      Italy. michele.carugno@unimi.it.
FAU - Riboldi, Luciano
AU  - Riboldi L
AD  - Occupational Health Unit, Fondazione IRCCS Ca' Granda Ospedale Maggiore 
      Policlinico, Milan, Italy. luciano.riboldi@policlinico.mi.it.
FAU - Ceriotti, Ferruccio
AU  - Ceriotti F
AD  - Clinical Laboratory, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, 
      Milan, Italy. ferruccio.ceriotti@policlinico.mi.it.
FAU - Bandera, Alessandra
AU  - Bandera A
AD  - Department of Pathophysiology and Transplantation, University of Milan, Milan, 
      Italy. alessandra.bandera@unimi.it.
FAU - Gori, Andrea
AU  - Gori A
AD  - Department of Pathophysiology and Transplantation, University of Milan, Milan, 
      Italy. andrea.gori@unimi.it.
FAU - Pesatori, Angela Cecilia
AU  - Pesatori AC
AD  - Department of Clinical Sciences and Community Health, University of Milan, Milan, 
      Italy. angela.pesatori@unimi.it.
LA  - eng
PT  - Journal Article
DEP - 20211223
PL  - Italy
TA  - Med Lav
JT  - La Medicina del lavoro
JID - 0401176
RN  - 0 (COVID-19 Vaccines)
RN  - 0 (RNA, Messenger)
RN  - N38TVC63NU (BNT162 Vaccine)
SB  - IM
MH  - Adult
MH  - BNT162 Vaccine
MH  - *COVID-19
MH  - *COVID-19 Vaccines
MH  - Female
MH  - Health Personnel
MH  - Hospitals
MH  - Humans
MH  - RNA, Messenger
MH  - SARS-CoV-2
PMC - PMC8759050
COIS- The authors declare no conflict of interest.
EDAT- 2021/12/24 06:00
MHDA- 2021/12/25 06:00
PMCR- 2021/01/01
CRDT- 2021/12/23 08:45
PHST- 2021/11/04 00:00 [received]
PHST- 2021/12/01 00:00 [accepted]
PHST- 2021/12/23 08:45 [entrez]
PHST- 2021/12/24 06:00 [pubmed]
PHST- 2021/12/25 06:00 [medline]
PHST- 2021/01/01 00:00 [pmc-release]
AID - MDL-112-477 [pii]
AID - 10.23749/mdl.v112i6.12507 [doi]
PST - epublish
SO  - Med Lav. 2021 Dec 23;112(6):477-485. doi: 10.23749/mdl.v112i6.12507.