PMID- 34942197
OWN - NLM
STAT- MEDLINE
DCOM- 20220621
LR  - 20230703
IS  - 1523-1747 (Electronic)
IS  - 0022-202X (Print)
IS  - 0022-202X (Linking)
VI  - 142
IP  - 7
DP  - 2022 Jul
TI  - Epidermal Fatty Acid‒Binding Protein Mediates Depilatory-Induced Acute Skin 
      Inflammation.
PG  - 1824-1834.e7
LID - S0022-202X(21)02623-3 [pii]
LID - 10.1016/j.jid.2021.11.040 [doi]
AB  - Depilatory creams are widely used to remove unwanted body hair, but people with 
      sensitive skin are subject to depilatory-induced skin burn/inflammation. It 
      remains unknown what makes their skin more sensitive than others. In this study, 
      we show that epidermal fatty acid‒binding protein (E-FABP) expressed in the skin 
      plays a critical role in promoting depilatory-induced acute skin inflammation in 
      mouse models. Although a depilatory cream removed hair by breaking down keratin 
      disulfide bonds, it activated cytosolic phospholipase A2, leading to activation 
      of the arachidonic acid/E-FABP/peroxisome proliferator-activated receptor beta 
      signaling pathway in keratinocytes. Specifically, peroxisome 
      proliferator-activated receptor beta activation induced downstream targets (e.g., 
      cyclooxygenase 2) and chemokine (e.g., CXCL1) production, which systemically 
      mobilized neutrophils and recruited them to localize in the skin for acute 
      inflammatory responses. Importantly, E-FABP deletion by CRISPR-Cas9 reduced 
      cytosolic phospholipase A2/peroxisome proliferator-activated receptor beta 
      activation in keratinocytes, and genetic deletion of E-FABP protected mice from 
      depilatory cream-induced neutrophil recruitment and skin inflammation. Our 
      findings suggest E-FABP as a molecular sensor for sensitive skin by triggering 
      depilatory-induced, lipid-mediated skin inflammatory responses.
CI  - Copyright (c) 2021 The Authors. Published by Elsevier Inc. All rights reserved.
FAU - Yin, Di
AU  - Yin D
AD  - Department of Microbiology & Immunology, School of Medicine, University of 
      Louisville, Louisville, Kentucky, USA; Department of Pathology, School of Basic 
      Medical Sciences, Guangzhou Medical University, Guangzhou, China.
FAU - Hao, Jiaqing
AU  - Hao J
AD  - Department of Microbiology & Immunology, School of Medicine, University of 
      Louisville, Louisville, Kentucky, USA.
FAU - Jin, Rong
AU  - Jin R
AD  - Department of Microbiology & Immunology, School of Medicine, University of 
      Louisville, Louisville, Kentucky, USA; Department of Immunology, School of Basic 
      Medical Sciences, Peking University Health Science Center, Beijing, China.
FAU - Yi, Yanmei
AU  - Yi Y
AD  - Department of Microbiology & Immunology, School of Medicine, University of 
      Louisville, Louisville, Kentucky, USA; Department of Histology and Embryology, 
      School of Basic Medical Sciences, Guangdong Medical University, Zhanjiang, China.
FAU - Bodduluri, Sobha R
AU  - Bodduluri SR
AD  - Department of Microbiology & Immunology, School of Medicine, University of 
      Louisville, Louisville, Kentucky, USA.
FAU - Hua, Yuan
AU  - Hua Y
AD  - Department of Microbiology & Immunology, School of Medicine, University of 
      Louisville, Louisville, Kentucky, USA.
FAU - Anand, Ajay
AU  - Anand A
AD  - Department of Microbiology & Immunology, School of Medicine, University of 
      Louisville, Louisville, Kentucky, USA.
FAU - Deng, Yibin
AU  - Deng Y
AD  - Department of Urology, University of Minnesota Medical School, Minneapolis, 
      Minnesota, USA; Masonic Cancer Center, University of Minnesota, Minneapolis, 
      Minnesota, USA.
FAU - Haribabu, Bodduluri
AU  - Haribabu B
AD  - Department of Microbiology & Immunology, School of Medicine, University of 
      Louisville, Louisville, Kentucky, USA.
FAU - Egilmez, Nejat K
AU  - Egilmez NK
AD  - Department of Microbiology & Immunology, School of Medicine, University of 
      Louisville, Louisville, Kentucky, USA.
FAU - Sauter, Edward R
AU  - Sauter ER
AD  - Division of Cancer Prevention, National Cancer Institute, National Institutes of 
      Health, Bethesda, Maryland, USA.
FAU - Li, Bing
AU  - Li B
AD  - Department of Microbiology & Immunology, School of Medicine, University of 
      Louisville, Louisville, Kentucky, USA. Electronic address: b.li@louisville.edu.
LA  - eng
GR  - R01 AI137324/AI/NIAID NIH HHS/United States
GR  - R01 CA180986/CA/NCI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
DEP - 20211221
PL  - United States
TA  - J Invest Dermatol
JT  - The Journal of investigative dermatology
JID - 0426720
RN  - 0 (Fabp5 protein, mouse)
RN  - 0 (Fatty Acid-Binding Proteins)
RN  - 0 (Neoplasm Proteins)
RN  - 0 (Peroxisome Proliferator-Activated Receptors)
RN  - EC 3.1.1.4 (Phospholipases A2)
SB  - IM
MH  - Animals
MH  - *Dermatitis/metabolism
MH  - *Fatty Acid-Binding Proteins/genetics
MH  - Humans
MH  - Inflammation/metabolism
MH  - Keratinocytes/metabolism
MH  - Mice
MH  - Neoplasm Proteins
MH  - *Peroxisome Proliferator-Activated Receptors/metabolism
MH  - Phospholipases A2/metabolism
PMC - PMC9639752
MID - NIHMS1766196
COIS- Conflicts of Interest The authors state no conflict of interest
EDAT- 2021/12/24 06:00
MHDA- 2022/06/22 06:00
PMCR- 2023/07/01
CRDT- 2021/12/23 20:13
PHST- 2021/07/30 00:00 [received]
PHST- 2021/11/04 00:00 [revised]
PHST- 2021/11/22 00:00 [accepted]
PHST- 2021/12/24 06:00 [pubmed]
PHST- 2022/06/22 06:00 [medline]
PHST- 2021/12/23 20:13 [entrez]
PHST- 2023/07/01 00:00 [pmc-release]
AID - S0022-202X(21)02623-3 [pii]
AID - 10.1016/j.jid.2021.11.040 [doi]
PST - ppublish
SO  - J Invest Dermatol. 2022 Jul;142(7):1824-1834.e7. doi: 10.1016/j.jid.2021.11.040. 
      Epub 2021 Dec 21.