PMID- 34942986
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20211229
IS  - 2076-3921 (Print)
IS  - 2076-3921 (Electronic)
IS  - 2076-3921 (Linking)
VI  - 10
IP  - 12
DP  - 2021 Nov 25
TI  - Anemopsis californica Attenuates Photoaging by Regulating MAPK, NRF2, and NFATc1 
      Signaling Pathways.
LID - 10.3390/antiox10121882 [doi]
LID - 1882
AB  - Long-term exposure of the skin to solar radiation causes chronic inflammation and 
      oxidative stress, which accelerates collagen degradation. This contributes to the 
      formation of wrinkles and dark spots, skin fragility, and even skin cancer. In 
      this study, Anemopsis californica (AC), a herb from North America that is well 
      known for treating microorganism infection and promoting wound healing, was 
      investigated for its photoprotective effects. The biological effects of AC were 
      studied on two in vitro models, namely, lipopolysaccharide (LPS)-induced 
      macrophages and ultraviolet B (UVB)-irradiated dermal fibroblasts, to 
      characterize its underlying molecular mechanisms. The results showed that AC 
      decreased the mRNA levels of inflammatory mediators in sensitized macrophages, 
      including cytokines, inducible nitric oxide synthase (iNOS), and cyclooxygenase 
      (COX-2). Moreover, AC alleviated UVB-induced photoaging in dermal fibroblasts by 
      restoring procollagen synthesis. This resulted from the regulation of excessive 
      reactive oxygen species (ROS) by AC, which was mediated by the activation of the 
      antioxidative system nuclear factor erythroid 2-related factor 2 (NRF2). AC also 
      alleviated oxidative stress and inflammatory responses by inhibiting the 
      phosphorylation of mitogen-activated protein kinase (MAPK) and interfering with 
      the nuclear translocation of the immune regulator nuclear factor of activated 
      T-cells 1 (NFATc1). In conclusion, the protective effects of AC on skin cellular 
      components suggested that it has the potential for use in the development of 
      drugs and cosmetics that protect the skin from UVB-induced chronic inflammation 
      and aging.
FAU - Nguyen, Quynh T N
AU  - Nguyen QTN
AD  - Graduate School of Biotechnology, Kyung Hee University, 1732 Deogyeong-daero, 
      Giheung-gu, Yongin-si 17104, Korea.
FAU - Fang, Minzhe
AU  - Fang M
AD  - Graduate School of Biotechnology, Kyung Hee University, 1732 Deogyeong-daero, 
      Giheung-gu, Yongin-si 17104, Korea.
FAU - Do, Nhung Quynh
AU  - Do NQ
AUID- ORCID: 0000-0001-9239-0904
AD  - Graduate School of Biotechnology, Kyung Hee University, 1732 Deogyeong-daero, 
      Giheung-gu, Yongin-si 17104, Korea.
FAU - Jeong, Jeehaeng
AU  - Jeong J
AD  - Snow White Factory, 807 Nonhyeon-ro, Gangnam-gu, Seoul 06032, Korea.
FAU - Oh, Sarang
AU  - Oh S
AD  - Snow White Factory, 807 Nonhyeon-ro, Gangnam-gu, Seoul 06032, Korea.
FAU - Zheng, Shengdao
AU  - Zheng S
AD  - Graduate School of Biotechnology, Kyung Hee University, 1732 Deogyeong-daero, 
      Giheung-gu, Yongin-si 17104, Korea.
FAU - Kim, Minseon
AU  - Kim M
AD  - Graduate School of Biotechnology, Kyung Hee University, 1732 Deogyeong-daero, 
      Giheung-gu, Yongin-si 17104, Korea.
AD  - Snow White Factory, 807 Nonhyeon-ro, Gangnam-gu, Seoul 06032, Korea.
FAU - Choi, Junhui
AU  - Choi J
AD  - Graduate School of Biotechnology, Kyung Hee University, 1732 Deogyeong-daero, 
      Giheung-gu, Yongin-si 17104, Korea.
FAU - Lim, Seojun
AU  - Lim S
AD  - Graduate School of Biotechnology, Kyung Hee University, 1732 Deogyeong-daero, 
      Giheung-gu, Yongin-si 17104, Korea.
FAU - Yi, Tae Hoo
AU  - Yi TH
AUID- ORCID: 0000-0001-9369-6542
AD  - Graduate School of Biotechnology, Kyung Hee University, 1732 Deogyeong-daero, 
      Giheung-gu, Yongin-si 17104, Korea.
LA  - eng
GR  - 20210491/Kyung Hee University/
PT  - Journal Article
DEP - 20211125
PL  - Switzerland
TA  - Antioxidants (Basel)
JT  - Antioxidants (Basel, Switzerland)
JID - 101668981
PMC - PMC8698643
OTO - NOTNLM
OT  - Anemopsis californica
OT  - nuclear factor erythroid 2-related factor 2 (NRF2)
OT  - nuclear factor of activated T-cells (NFAT)
OT  - oxidative stress
OT  - photoaging
COIS- The authors declare no conflict of interest.
EDAT- 2021/12/25 06:00
MHDA- 2021/12/25 06:01
PMCR- 2021/11/25
CRDT- 2021/12/24 01:01
PHST- 2021/11/02 00:00 [received]
PHST- 2021/11/19 00:00 [revised]
PHST- 2021/11/23 00:00 [accepted]
PHST- 2021/12/24 01:01 [entrez]
PHST- 2021/12/25 06:00 [pubmed]
PHST- 2021/12/25 06:01 [medline]
PHST- 2021/11/25 00:00 [pmc-release]
AID - antiox10121882 [pii]
AID - antioxidants-10-01882 [pii]
AID - 10.3390/antiox10121882 [doi]
PST - epublish
SO  - Antioxidants (Basel). 2021 Nov 25;10(12):1882. doi: 10.3390/antiox10121882.