PMID- 34943132
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20211228
IS  - 2076-3921 (Print)
IS  - 2076-3921 (Electronic)
IS  - 2076-3921 (Linking)
VI  - 10
IP  - 12
DP  - 2021 Dec 20
TI  - Preventing Oxidative Stress in the Liver: An Opportunity for GLP-1 and/or PASK.
LID - 10.3390/antiox10122028 [doi]
LID - 2028
AB  - The liver's high metabolic activity and detoxification functions generate 
      reactive oxygen species, mainly through oxidative phosphorylation in the 
      mitochondria of hepatocytes. In contrast, it also has a potent antioxidant 
      mechanism for counterbalancing the oxidant's effect and relieving oxidative 
      stress. PAS kinase (PASK) is a serine/threonine kinase containing an N-terminal 
      Per-Arnt-Sim (PAS) domain, able to detect redox state. During fasting/feeding 
      changes, PASK regulates the expression and activation of critical liver proteins 
      involved in carbohydrate and lipid metabolism and mitochondrial biogenesis. 
      Interestingly, the functional inactivation of PASK prevents the development of a 
      high-fat diet (HFD)-induced obesity and diabetes. In addition, PASK deficiency 
      alters the activity of other nutrient sensors, such as the AMP-activated protein 
      kinase (AMPK) and the mammalian target of rapamycin (mTOR). In addition to the 
      expression and subcellular localization of nicotinamide-dependent histone 
      deacetylases (SIRTs). This review focuses on the relationship between oxidative 
      stress, PASK, and other nutrient sensors, updating the limited knowledge on the 
      role of PASK in the antioxidant response. We also comment on glucagon-like 
      peptide 1 (GLP-1) and its collaboration with PASK in preventing the damage 
      associated with hepatic oxidative stress. The current knowledge would suggest 
      that PASK inhibition and/or exendin-4 treatment, especially under fasting 
      conditions, could ameliorate disorders associated with excess oxidative stress.
FAU - Hurtado-Carneiro, Veronica
AU  - Hurtado-Carneiro V
AUID- ORCID: 0000-0003-2517-8895
AD  - Department of Physiology, Faculty of Medicine, Institute of Medical Research at 
      the San Carlos Clinic Hospital (IdISSC), Complutense University of Madrid, Ciudad 
      Universitaria, 28040 Madrid, Spain.
AD  - Department of Biochemistry and Molecular Biology, Faculty of Medicine, Institute 
      of Medical Research at the San Carlos Clinic Hospital (IdISSC), Complutense 
      University of Madrid, Ciudad Universitaria, 28040 Madrid, Spain.
FAU - Dongil, Pilar
AU  - Dongil P
AD  - Department of Biochemistry and Molecular Biology, Faculty of Medicine, Institute 
      of Medical Research at the San Carlos Clinic Hospital (IdISSC), Complutense 
      University of Madrid, Ciudad Universitaria, 28040 Madrid, Spain.
AD  - Department of Cell Biology, Faculty of Medicine, Institute of Medical Research at 
      the San Carlos Clinic Hospital (IdISSC), Complutense University of Madrid, Ciudad 
      Universitaria, 28040 Madrid, Spain.
FAU - Perez-Garcia, Ana
AU  - Perez-Garcia A
AD  - Department of Biochemistry and Molecular Biology, Faculty of Medicine, Institute 
      of Medical Research at the San Carlos Clinic Hospital (IdISSC), Complutense 
      University of Madrid, Ciudad Universitaria, 28040 Madrid, Spain.
AD  - Department of Cell Biology, Faculty of Medicine, Institute of Medical Research at 
      the San Carlos Clinic Hospital (IdISSC), Complutense University of Madrid, Ciudad 
      Universitaria, 28040 Madrid, Spain.
FAU - Alvarez, Elvira
AU  - Alvarez E
AUID- ORCID: 0000-0002-9074-3857
AD  - Department of Biochemistry and Molecular Biology, Faculty of Medicine, Institute 
      of Medical Research at the San Carlos Clinic Hospital (IdISSC), Complutense 
      University of Madrid, Ciudad Universitaria, 28040 Madrid, Spain.
FAU - Sanz, Carmen
AU  - Sanz C
AUID- ORCID: 0000-0001-7025-6667
AD  - Department of Cell Biology, Faculty of Medicine, Institute of Medical Research at 
      the San Carlos Clinic Hospital (IdISSC), Complutense University of Madrid, Ciudad 
      Universitaria, 28040 Madrid, Spain.
LA  - eng
GR  - GRFN17/21 and PR87/19-22548/Complutense University-Banco Santander Funding 
      Programme/
PT  - Journal Article
PT  - Review
DEP - 20211220
PL  - Switzerland
TA  - Antioxidants (Basel)
JT  - Antioxidants (Basel, Switzerland)
JID - 101668981
PMC - PMC8698360
OTO - NOTNLM
OT  - antioxidants
OT  - exendin-4
OT  - metabolic sensors
COIS- The authors declare no conflict of interest.
EDAT- 2021/12/25 06:00
MHDA- 2021/12/25 06:01
PMCR- 2021/12/20
CRDT- 2021/12/24 01:01
PHST- 2021/10/19 00:00 [received]
PHST- 2021/12/14 00:00 [revised]
PHST- 2021/12/15 00:00 [accepted]
PHST- 2021/12/24 01:01 [entrez]
PHST- 2021/12/25 06:00 [pubmed]
PHST- 2021/12/25 06:01 [medline]
PHST- 2021/12/20 00:00 [pmc-release]
AID - antiox10122028 [pii]
AID - antioxidants-10-02028 [pii]
AID - 10.3390/antiox10122028 [doi]
PST - epublish
SO  - Antioxidants (Basel). 2021 Dec 20;10(12):2028. doi: 10.3390/antiox10122028.