PMID- 34943576
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20211228
IS  - 2075-4418 (Print)
IS  - 2075-4418 (Electronic)
IS  - 2075-4418 (Linking)
VI  - 11
IP  - 12
DP  - 2021 Dec 12
TI  - Neurogranin as a Reliable Biomarker for Synaptic Dysfunction in Alzheimer's 
      Disease.
LID - 10.3390/diagnostics11122339 [doi]
LID - 2339
AB  - (1) Background: Neurogranin is a post-synaptic protein expressed in the neurons 
      of the hippocampus and cerebral cortex. It has been recently proposed as a 
      promising biomarker of synaptic dysfunction, especially in Alzheimer's disease 
      (AD). However, more efforts are needed before introducing it in clinical 
      practice, including the definition of its reference interval (RI). The aim of the 
      study was to establish the RI of cerebrospinal fluid (CSF) neurogranin levels in 
      controls and individuals with non-neurodegenerative neurological diseases; (2) We 
      included a total of 136 individuals that were sub-grouped as follows: AD patients 
      (n = 33), patients with non-neurodegenerative neurological diseases (n = 70) and 
      controls (33). We measured CSF neurogranin levels by a commercial ELISA kit. CSF 
      RI of neurogranin was calculated by a robust method; (3) Results: AD patients 
      showed increased levels of neurogranin. We also found that neurogranin was 
      significantly correlated with T-tau, P-tau and mini mental state examination in 
      AD patients. The lower and upper reference limits of the RI were 2.9 (90%CI 
      0.1-10.8) and 679 (90%CI 595-779), respectively; (4) Conclusion: This is the 
      first study establishing the RI of CSF neurogranin.
FAU - Agnello, Luisa
AU  - Agnello L
AD  - Department of Biomedicine, Neurosciences and Advanced Diagnostics, Institute of 
      Clinical Biochemistry, Clinical Molecular Medicine and Clinical Laboratory 
      Medicine, University of Palermo, 90127 Palermo, Italy.
FAU - Lo Sasso, Bruna
AU  - Lo Sasso B
AD  - Department of Biomedicine, Neurosciences and Advanced Diagnostics, Institute of 
      Clinical Biochemistry, Clinical Molecular Medicine and Clinical Laboratory 
      Medicine, University of Palermo, 90127 Palermo, Italy.
AD  - Department of Laboratory Medicine, Azienda Ospedaliera Universitaria Policlinico 
      "P. Giaccone", 90127 Palermo, Italy.
FAU - Vidali, Matteo
AU  - Vidali M
AUID- ORCID: 0000-0001-9991-7502
AD  - Foundation IRCCS Ca' Granda Ospedale Maggiore Policlinico, 20122 Milan, Italy.
FAU - Scazzone, Concetta
AU  - Scazzone C
AD  - Department of Biomedicine, Neurosciences and Advanced Diagnostics, Institute of 
      Clinical Biochemistry, Clinical Molecular Medicine and Clinical Laboratory 
      Medicine, University of Palermo, 90127 Palermo, Italy.
FAU - Piccoli, Tommaso
AU  - Piccoli T
AUID- ORCID: 0000-0003-3410-2067
AD  - Unit of Neurology, Department of Biomedicine, Neurosciences and Advanced 
      Diagnostics, University of Palermo, 90127 Palermo, Italy.
FAU - Gambino, Caterina Maria
AU  - Gambino CM
AD  - Department of Biomedicine, Neurosciences and Advanced Diagnostics, Institute of 
      Clinical Biochemistry, Clinical Molecular Medicine and Clinical Laboratory 
      Medicine, University of Palermo, 90127 Palermo, Italy.
FAU - Bivona, Giulia
AU  - Bivona G
AUID- ORCID: 0000-0003-1723-3305
AD  - Department of Biomedicine, Neurosciences and Advanced Diagnostics, Institute of 
      Clinical Biochemistry, Clinical Molecular Medicine and Clinical Laboratory 
      Medicine, University of Palermo, 90127 Palermo, Italy.
FAU - Giglio, Rosaria Vincenza
AU  - Giglio RV
AD  - Department of Biomedicine, Neurosciences and Advanced Diagnostics, Institute of 
      Clinical Biochemistry, Clinical Molecular Medicine and Clinical Laboratory 
      Medicine, University of Palermo, 90127 Palermo, Italy.
FAU - Ciaccio, Anna Maria
AU  - Ciaccio AM
AD  - Unit of Clinical Biochemistry, University of Palermo, 90127 Palermo, Italy.
FAU - La Bella, Vincenzo
AU  - La Bella V
AUID- ORCID: 0000-0003-2045-1864
AD  - ALS Clinical Research Center, Department of Biomedicine, Neuroscience and 
      Advanced Diagnostics, University of Palermo, 90129 Palermo, Italy.
FAU - Ciaccio, Marcello
AU  - Ciaccio M
AUID- ORCID: 0000-0001-6120-9041
AD  - Department of Biomedicine, Neurosciences and Advanced Diagnostics, Institute of 
      Clinical Biochemistry, Clinical Molecular Medicine and Clinical Laboratory 
      Medicine, University of Palermo, 90127 Palermo, Italy.
AD  - Department of Laboratory Medicine, Azienda Ospedaliera Universitaria Policlinico 
      "P. Giaccone", 90127 Palermo, Italy.
LA  - eng
PT  - Journal Article
DEP - 20211212
PL  - Switzerland
TA  - Diagnostics (Basel)
JT  - Diagnostics (Basel, Switzerland)
JID - 101658402
PMC - PMC8700711
OTO - NOTNLM
OT  - RC3
OT  - biomarkers
OT  - controls
OT  - diagnosis
OT  - neurodegeneration
OT  - prognosis
OT  - tau
COIS- The authors declare no conflict of interest.
EDAT- 2021/12/25 06:00
MHDA- 2021/12/25 06:01
PMCR- 2021/12/12
CRDT- 2021/12/24 01:03
PHST- 2021/09/16 00:00 [received]
PHST- 2021/12/07 00:00 [revised]
PHST- 2021/12/10 00:00 [accepted]
PHST- 2021/12/24 01:03 [entrez]
PHST- 2021/12/25 06:00 [pubmed]
PHST- 2021/12/25 06:01 [medline]
PHST- 2021/12/12 00:00 [pmc-release]
AID - diagnostics11122339 [pii]
AID - diagnostics-11-02339 [pii]
AID - 10.3390/diagnostics11122339 [doi]
PST - epublish
SO  - Diagnostics (Basel). 2021 Dec 12;11(12):2339. doi: 10.3390/diagnostics11122339.