PMID- 34944468
OWN - NLM
STAT- MEDLINE
DCOM- 20220119
LR  - 20220119
IS  - 2218-273X (Electronic)
IS  - 2218-273X (Linking)
VI  - 11
IP  - 12
DP  - 2021 Dec 3
TI  - Hyperbaric Oxygen Treatment: Effects on Mitochondrial Function and Oxidative 
      Stress.
LID - 10.3390/biom11121827 [doi]
LID - 1827
AB  - Hyperbaric oxygen treatment (HBOT)-the administration of 100% oxygen at 
      atmospheric pressure (ATA) greater than 1 ATA-increases the proportion of 
      dissolved oxygen in the blood five- to twenty-fold. This increase in accessible 
      oxygen places the mitochondrion-the organelle that consumes most of the oxygen 
      that we breathe-at the epicenter of HBOT's effects. As the mitochondrion is also 
      a major site for the production of reactive oxygen species (ROS), it is possible 
      that HBOT will increase also oxidative stress. Depending on the conditions of the 
      HBO treatment (duration, pressure, umber of treatments), short-term treatments 
      have been shown to have deleterious effects on both mitochondrial activity and 
      production of ROS. Long-term treatment, on the other hand, improves mitochondrial 
      activity and leads to a decrease in ROS levels, partially due to the effects of 
      HBOT, which increases antioxidant defense mechanisms. Many diseases and 
      conditions are characterized by mitochondrial dysfunction and imbalance between 
      ROS and antioxidant scavengers, suggesting potential therapeutic intervention for 
      HBOT. In the present review, we will present current views on the effects of HBOT 
      on mitochondrial function and oxidative stress, the interplay between them and 
      the implications for several diseases.
FAU - Schottlender, Nofar
AU  - Schottlender N
AUID- ORCID: 0000-0002-3835-2381
AD  - School of Neurobiology, Biochemistry and Biophysics, Life Sciences Faculty, Tel 
      Aviv University, Tel Aviv 69978, Israel.
AD  - Sagol School of Neuroscience, Tel Aviv University, Tel Aviv 69978, Israel.
FAU - Gottfried, Irit
AU  - Gottfried I
AUID- ORCID: 0000-0002-5927-4626
AD  - School of Neurobiology, Biochemistry and Biophysics, Life Sciences Faculty, Tel 
      Aviv University, Tel Aviv 69978, Israel.
FAU - Ashery, Uri
AU  - Ashery U
AD  - School of Neurobiology, Biochemistry and Biophysics, Life Sciences Faculty, Tel 
      Aviv University, Tel Aviv 69978, Israel.
AD  - Sagol School of Neuroscience, Tel Aviv University, Tel Aviv 69978, Israel.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20211203
PL  - Switzerland
TA  - Biomolecules
JT  - Biomolecules
JID - 101596414
RN  - 0 (Reactive Oxygen Species)
SB  - IM
MH  - Humans
MH  - Hyperbaric Oxygenation/adverse effects/*methods
MH  - Mitochondria/*metabolism
MH  - Oxidative Stress
MH  - Reactive Oxygen Species/*metabolism
MH  - Time Factors
PMC - PMC8699286
OTO - NOTNLM
OT  - HIF1a
OT  - Nrf2
OT  - SIRT1
OT  - hyperbaric oxygen treatment (HBOT)
OT  - hyperoxic-hypoxic paradox
OT  - mitochondrial function
OT  - neuroinflammation
OT  - oxidative stress
OT  - reactive oxygen species (ROS)
OT  - superoxide dismutase (SOD)
COIS- The authors declare no conflict of interest.
EDAT- 2021/12/25 06:00
MHDA- 2022/01/20 06:00
PMCR- 2021/12/03
CRDT- 2021/12/24 01:05
PHST- 2021/11/04 00:00 [received]
PHST- 2021/11/29 00:00 [revised]
PHST- 2021/11/30 00:00 [accepted]
PHST- 2021/12/24 01:05 [entrez]
PHST- 2021/12/25 06:00 [pubmed]
PHST- 2022/01/20 06:00 [medline]
PHST- 2021/12/03 00:00 [pmc-release]
AID - biom11121827 [pii]
AID - biomolecules-11-01827 [pii]
AID - 10.3390/biom11121827 [doi]
PST - epublish
SO  - Biomolecules. 2021 Dec 3;11(12):1827. doi: 10.3390/biom11121827.