PMID- 34945723
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20211229
IS  - 2075-4426 (Print)
IS  - 2075-4426 (Electronic)
IS  - 2075-4426 (Linking)
VI  - 11
IP  - 12
DP  - 2021 Nov 25
TI  - Pre-Treatment Neutrophil-to-Lymphocyte and Platelet-to-Lymphocyte Ratios as 
      Predictors of Occult Cervical Metastasis in Clinically Negative Neck Supraglottic 
      and Glottic Cancer.
LID - 10.3390/jpm11121252 [doi]
LID - 1252
AB  - Background. Among patients with diagnosis of Laryngeal Squamous Cell Carcinoma 
      (LSCC), up to 37.5% of cases may have occult metastasis (OM), and this feature is 
      linked to poor prognosis and high rate of local recurrence. The role of elective 
      neck dissection (END) in clinically negative neck (cN0) LSCC remains 
      controversial. It is of great value to search for low-cost and easily detectable 
      indicators to predict the risk of OM in laryngeal cancer. Recent reports have 
      shown that high values of the neutrophil-to-lymphocyte ratio (NLR) and 
      platelet-to-lymphocyte ratio (PLR) represent a negative prognostic factor in head 
      and neck cancers. The aim of our study has been to investigate the value of 
      pre-treatment NLR and PLR with regard to predicting occult cervical metastasis in 
      cN0 supraglottic and glottic LSCC. Materials and methods. Data of patients 
      affected by LSCC, who had been surgically treated by means of laryngectomy 
      (total, horizontal partial and supracricoid) and END between January 2006 and 
      January 2021, were retrospectively reviewed, using information retrieved from a 
      database dedicated to such procedures in a single tertiary care referral 
      institute. Results. A total of 387 patients were treated for LSCC at our 
      Institute from 2006 to 2021, but only 108 of them met the inclusion criteria. The 
      median age at the time of diagnosis was 64 years (range, 39-89 years). All the 
      tumors were treated with a laryngectomy and an END. A total of 27.7% of patients 
      were found positive for neck node metastasis (the pN+ group), while 78/108 
      (72.3%) patients were found to be negative for the presence of neck metastasis 
      (the pN0 group). High values of NLR, but not PLR, significantly correlated with 
      the probability of OM, and according to the iterative algorithm of 
      Newton-Raphson, an NLR value of 2.26 corresponds to a probability of OM of 20%. 
      Conclusion. Our analysis revealed a statistical correlation between high NLR 
      pre-treatment values and positive neck OM in patients with LSCC.
FAU - Salzano, Giovanni
AU  - Salzano G
AUID- ORCID: 0000-0003-3947-8733
AD  - Maxillo-Facial and ENT Surgery Unit, INT-IRCCS "Fondazione G. Pascale", 80131 
      Naples, Italy.
FAU - Perri, Francesco
AU  - Perri F
AUID- ORCID: 0000-0001-8158-7509
AD  - Head and Neck Medical and Experimental Oncology Unit, INT IRCCS Fondazione 
      Giovanni Pascale, 80131 Naples, Italy.
FAU - Maglitto, Fabio
AU  - Maglitto F
AD  - Maxillofacial Surgery Unit, Department of Neurosciences, Reproductive and 
      Odontostomatological Sciences, University Federico II, 80131 Naples, Italy.
FAU - Togo, Giulia
AU  - Togo G
AD  - Maxillofacial Surgery Unit, Department of Neurosciences, Reproductive and 
      Odontostomatological Sciences, University Federico II, 80131 Naples, Italy.
FAU - De Fazio, Gianluca Renato
AU  - De Fazio GR
AD  - Maxillofacial Surgery Unit, Department of Neurosciences, Reproductive and 
      Odontostomatological Sciences, University Federico II, 80131 Naples, Italy.
FAU - Apolito, Michela
AU  - Apolito M
AUID- ORCID: 0000-0002-1810-6191
AD  - Maxillofacial Surgery Unit, Department of Neurosciences, Reproductive and 
      Odontostomatological Sciences, University Federico II, 80131 Naples, Italy.
FAU - Calabria, Federica
AU  - Calabria F
AD  - Maxillofacial Surgery Unit, Department of Neurosciences, Reproductive and 
      Odontostomatological Sciences, University Federico II, 80131 Naples, Italy.
FAU - Laface, Claudia
AU  - Laface C
AD  - Maxillofacial Surgery Unit, Department of Neurosciences, Reproductive and 
      Odontostomatological Sciences, University Federico II, 80131 Naples, Italy.
FAU - Vaira, Luigi Angelo
AU  - Vaira LA
AUID- ORCID: 0000-0002-7789-145X
AD  - Maxillofacial Surgery Unit, University Hospital of Sassari, 07100 Sassari, Italy.
FAU - Committeri, Umberto
AU  - Committeri U
AUID- ORCID: 0000-0002-9444-0052
AD  - Maxillo-Facial and ENT Surgery Unit, INT-IRCCS "Fondazione G. Pascale", 80131 
      Naples, Italy.
FAU - Balia, Mario
AU  - Balia M
AD  - Maxillofacial Surgery Unit, University of Naples Federico II, Via Sergio Pansini 
      5, 80131 Naples, Italy.
FAU - Pavone, Ettore
AU  - Pavone E
AD  - Maxillo-Facial and ENT Surgery Unit, INT-IRCCS "Fondazione G. Pascale", 80131 
      Naples, Italy.
FAU - Aversa, Corrado
AU  - Aversa C
AD  - Maxillo-Facial and ENT Surgery Unit, INT-IRCCS "Fondazione G. Pascale", 80131 
      Naples, Italy.
FAU - Salzano, Francesco Antonio
AU  - Salzano FA
AUID- ORCID: 0000-0003-4090-8120
AD  - Department of Medicine, Surgery and Dentistry, "Scuola Medica Salernitana", 
      University of Salerno, 84081 Baronissi, Italy.
FAU - Abbate, Vincenzo
AU  - Abbate V
AUID- ORCID: 0000-0002-7905-0531
AD  - Maxillofacial Surgery Unit, Department of Neurosciences, Reproductive and 
      Odontostomatological Sciences, University Federico II, 80131 Naples, Italy.
FAU - Ottaiano, Alessandro
AU  - Ottaiano A
AUID- ORCID: 0000-0002-2901-3855
AD  - SSD Innovative Therapies for Abdominal Metastases, Istituto Nazionale Tumori 
      IRCCS Fondazione G. Pascale, 80131 Naples, Italy.
FAU - Cascella, Marco
AU  - Cascella M
AUID- ORCID: 0000-0002-5236-3132
AD  - Division of Anesthesia, Istituto Nazionale Tumori, IRCCS Fondazione G. Pascale, 
      80131 Naples, Italy.
FAU - Santorsola, Mariachiara
AU  - Santorsola M
AD  - SSD Innovative Therapies for Abdominal Metastases, Istituto Nazionale Tumori 
      IRCCS Fondazione G. Pascale, 80131 Naples, Italy.
FAU - Fusco, Roberta
AU  - Fusco R
AD  - Oncology Medical Division, Igea SpA, 80127 Naples, Italy.
FAU - Califano, Luigi
AU  - Califano L
AD  - Maxillofacial Surgery Unit, Department of Neurosciences, Reproductive and 
      Odontostomatological Sciences, University Federico II, 80131 Naples, Italy.
FAU - Ionna, Franco
AU  - Ionna F
AD  - Maxillo-Facial and ENT Surgery Unit, INT-IRCCS "Fondazione G. Pascale", 80131 
      Naples, Italy.
LA  - eng
PT  - Journal Article
DEP - 20211125
PL  - Switzerland
TA  - J Pers Med
JT  - Journal of personalized medicine
JID - 101602269
PMC - PMC8706672
OTO - NOTNLM
OT  - elective neck dissection
OT  - laryngeal carcinoma
OT  - neck metastases
OT  - neutrophil-to-lymphocyte ratio
OT  - platelet-to-lymphocyte ratio
COIS- The authors declare no conflict of interest.
EDAT- 2021/12/25 06:00
MHDA- 2021/12/25 06:01
PMCR- 2021/11/25
CRDT- 2021/12/24 01:09
PHST- 2021/11/03 00:00 [received]
PHST- 2021/11/19 00:00 [revised]
PHST- 2021/11/23 00:00 [accepted]
PHST- 2021/12/24 01:09 [entrez]
PHST- 2021/12/25 06:00 [pubmed]
PHST- 2021/12/25 06:01 [medline]
PHST- 2021/11/25 00:00 [pmc-release]
AID - jpm11121252 [pii]
AID - jpm-11-01252 [pii]
AID - 10.3390/jpm11121252 [doi]
PST - epublish
SO  - J Pers Med. 2021 Nov 25;11(12):1252. doi: 10.3390/jpm11121252.