PMID- 34946260
OWN - NLM
STAT- MEDLINE
DCOM- 20211227
LR  - 20211229
IS  - 1648-9144 (Electronic)
IS  - 1010-660X (Print)
IS  - 1010-660X (Linking)
VI  - 57
IP  - 12
DP  - 2021 Nov 30
TI  - Determining Response to Treatment for Drug-Induced Bronchocentric Granulomatosis 
      by the Forced Oscillation Technique.
LID - 10.3390/medicina57121315 [doi]
LID - 1315
AB  - Anti-tumor necrosis factor alpha (TNFalpha) therapy is widely used to treat various 
      inflammatory conditions. Paradoxically, there are several case reports describing 
      the development of bronchocentric granulomatosis treated with TNFalpha inhibitors, 
      and it is difficult to determine the effect of treatment using conventional 
      spirometry because the lesions are located in small airways. However, it has been 
      reported that the forced oscillation technique (FOT) is useful in the evaluation 
      of small airway disease in bronchial asthma or chronic obstructive pulmonary 
      disease. We performed the FOT to determine the effect of treatment on 
      bronchocentric granulomatosis and found it to be useful. We report the case of a 
      55-year-old female with ulcerative colitis who was treated with golimumab and who 
      developed bronchocentric granulomatosis as a sarcoid-like reaction to golimumab. 
      She was successfully treated with prednisone, and the treatment efficacy was 
      confirmed by the FOT. The FOT may be useful in the evaluation of small airway 
      disease in bronchocentric granulomatosis. This case may help inform clinicians of 
      the usefulness of the FOT to assess small airway disease in various diseases.
FAU - Fukahori, Susumu
AU  - Fukahori S
AUID- ORCID: 0000-0003-2709-8880
AD  - Department of Respiratory Medicine, Nagasaki University Hospital, 1-7-1 Sakamoto, 
      Nagasaki 852-8501, Japan.
FAU - Obase, Yasushi
AU  - Obase Y
AUID- ORCID: 0000-0001-8838-7403
AD  - Department of Respiratory Medicine, Nagasaki University Hospital, 1-7-1 Sakamoto, 
      Nagasaki 852-8501, Japan.
AD  - Department of Respiratory Medicine, Graduate School of Biomedical Sciences, 
      Nagasaki University, 1-7-1 Sakamoto, Nagasaki 852-8501, Japan.
FAU - Fukushima, Chizu
AU  - Fukushima C
AD  - Department of Respiratory Medicine, Nagasaki University Hospital, 1-7-1 Sakamoto, 
      Nagasaki 852-8501, Japan.
FAU - Takao, Daisuke
AU  - Takao D
AD  - Department of Respiratory Medicine, Nagasaki University Hospital, 1-7-1 Sakamoto, 
      Nagasaki 852-8501, Japan.
FAU - Iriki, Jun
AU  - Iriki J
AD  - Department of Respiratory Medicine, Nagasaki University Hospital, 1-7-1 Sakamoto, 
      Nagasaki 852-8501, Japan.
FAU - Ozasa, Mutsumi
AU  - Ozasa M
AD  - Department of Pathology, Nagasaki University Hospital, 1-7-1 Sakamoto, Nagasaki 
      852-8501, Japan.
FAU - Zaizen, Yoshiaki
AU  - Zaizen Y
AUID- ORCID: 0000-0003-2274-4599
AD  - Department of Pathology, Nagasaki University Hospital, 1-7-1 Sakamoto, Nagasaki 
      852-8501, Japan.
FAU - Takamura, Noboru
AU  - Takamura N
AUID- ORCID: 0000-0002-5552-3234
AD  - Atomic Bomb Disease Institute, Nagasaki University, 1-12-4 Sakamoto, Nagasaki 
      852-8523, Japan.
FAU - Fukuoka, Junya
AU  - Fukuoka J
AD  - Department of Pathology, Nagasaki University Hospital, 1-7-1 Sakamoto, Nagasaki 
      852-8501, Japan.
FAU - Ashizawa, Kazuto
AU  - Ashizawa K
AUID- ORCID: 0000-0001-6726-1297
AD  - Department of Clinical Oncology, Graduate School of Biomedical Sciences, Nagasaki 
      University 1-7-1 Sakamoto, Nagasaki 852-8501, Japan.
FAU - Mukae, Hiroshi
AU  - Mukae H
AD  - Department of Respiratory Medicine, Nagasaki University Hospital, 1-7-1 Sakamoto, 
      Nagasaki 852-8501, Japan.
AD  - Department of Respiratory Medicine, Graduate School of Biomedical Sciences, 
      Nagasaki University, 1-7-1 Sakamoto, Nagasaki 852-8501, Japan.
LA  - eng
GR  - Non-profit Organization Aimed to Support Community Medicine Research in Nagasaki/
GR  - GlaxoSmithKline Co. Ltd/
PT  - Case Reports
DEP - 20211130
PL  - Switzerland
TA  - Medicina (Kaunas)
JT  - Medicina (Kaunas, Lithuania)
JID - 9425208
RN  - 0 (Pharmaceutical Preparations)
SB  - IM
MH  - *Asthma/drug therapy
MH  - Female
MH  - Humans
MH  - Middle Aged
MH  - *Pharmaceutical Preparations
MH  - *Pulmonary Disease, Chronic Obstructive/drug therapy
MH  - Respiratory Function Tests
MH  - Spirometry
PMC - PMC8704422
OTO - NOTNLM
OT  - anti-tumor necrosis factor alpha therapy
OT  - bronchocentric granulomatosis
OT  - forced oscillation technique
OT  - golimumab
OT  - inflammatory bowel disease
OT  - sarcoid-like reaction
OT  - small airway disease
OT  - ulcerative colitis
COIS- The authors declare no conflict of interest.
EDAT- 2021/12/25 06:00
MHDA- 2021/12/28 06:00
PMCR- 2021/11/30
CRDT- 2021/12/24 01:11
PHST- 2021/09/14 00:00 [received]
PHST- 2021/11/13 00:00 [revised]
PHST- 2021/11/25 00:00 [accepted]
PHST- 2021/12/24 01:11 [entrez]
PHST- 2021/12/25 06:00 [pubmed]
PHST- 2021/12/28 06:00 [medline]
PHST- 2021/11/30 00:00 [pmc-release]
AID - medicina57121315 [pii]
AID - medicina-57-01315 [pii]
AID - 10.3390/medicina57121315 [doi]
PST - epublish
SO  - Medicina (Kaunas). 2021 Nov 30;57(12):1315. doi: 10.3390/medicina57121315.