PMID- 34948152
OWN - NLM
STAT- MEDLINE
DCOM- 20220110
LR  - 20220110
IS  - 1422-0067 (Electronic)
IS  - 1422-0067 (Linking)
VI  - 22
IP  - 24
DP  - 2021 Dec 12
TI  - Impairments of Long-Term Synaptic Plasticity in the Hippocampus of Young Rats 
      during the Latent Phase of the Lithium-Pilocarpine Model of Temporal Lobe 
      Epilepsy.
LID - 10.3390/ijms222413355 [doi]
LID - 13355
AB  - Status epilepticus (SE) causes persistent abnormalities in the functioning of 
      neuronal networks, often resulting in worsening epileptic seizures. Many details 
      of cellular and molecular mechanisms of seizure-induced changes are still 
      unknown. The lithium-pilocarpine model of epilepsy in rats reproduces many 
      features of human temporal lobe epilepsy. In this work, using the 
      lithium-pilocarpine model in three-week-old rats, we examined the morphological 
      and electrophysiological changes in the hippocampus within a week following 
      pilocarpine-induced seizures. We found that almost a third of the neurons in the 
      hippocampus and dentate gyrus died on the first day, but this was not accompanied 
      by impaired synaptic plasticity at that time. A diminished long-term potentiation 
      (LTP) was observed following three days, and the negative effect of SE on 
      plasticity increased one week later, being accompanied by astrogliosis. The 
      attenuation of LTP was caused by the weakening of N-methyl-D-aspartate receptor 
      (NMDAR)-dependent signaling. NMDAR-current was more than two-fold weaker during 
      high-frequency stimulation in the post-SE rats than in the control group. 
      Application of glial transmitter D-serine, a coagonist of NMDARs, allows the 
      enhancement of the NMDAR-dependent current and the restoration of LTP. These 
      results suggest that the disorder of neuron-astrocyte interactions plays a 
      critical role in the impairment of synaptic plasticity.
FAU - Postnikova, Tatyana Y
AU  - Postnikova TY
AUID- ORCID: 0000-0002-7049-4478
AD  - Sechenov Institute of Evolutionary Physiology and Biochemistry of RAS, Saint 
      Petersburg 194223, Russia.
FAU - Diespirov, Georgy P
AU  - Diespirov GP
AD  - Sechenov Institute of Evolutionary Physiology and Biochemistry of RAS, Saint 
      Petersburg 194223, Russia.
FAU - Amakhin, Dmitry V
AU  - Amakhin DV
AD  - Sechenov Institute of Evolutionary Physiology and Biochemistry of RAS, Saint 
      Petersburg 194223, Russia.
FAU - Vylekzhanina, Elizaveta N
AU  - Vylekzhanina EN
AD  - Sechenov Institute of Evolutionary Physiology and Biochemistry of RAS, Saint 
      Petersburg 194223, Russia.
FAU - Soboleva, Elena B
AU  - Soboleva EB
AD  - Sechenov Institute of Evolutionary Physiology and Biochemistry of RAS, Saint 
      Petersburg 194223, Russia.
FAU - Zaitsev, Aleksey V
AU  - Zaitsev AV
AUID- ORCID: 0000-0002-4503-0647
AD  - Sechenov Institute of Evolutionary Physiology and Biochemistry of RAS, Saint 
      Petersburg 194223, Russia.
LA  - eng
GR  - 21-15-00430/Russian Science Foundation/
PT  - Journal Article
DEP - 20211212
PL  - Switzerland
TA  - Int J Mol Sci
JT  - International journal of molecular sciences
JID - 101092791
RN  - 01MI4Q9DI3 (Pilocarpine)
RN  - 9FN79X2M3F (Lithium)
SB  - IM
MH  - Animals
MH  - Disease Models, Animal
MH  - Epilepsy, Temporal Lobe/chemically induced/metabolism/*physiopathology
MH  - Hippocampus/metabolism/*physiopathology
MH  - Lithium/*adverse effects/pharmacology
MH  - Long-Term Potentiation/*drug effects
MH  - Male
MH  - Pilocarpine/*adverse effects/pharmacology
MH  - Rats
MH  - Rats, Wistar
PMC - PMC8705146
OTO - NOTNLM
OT  - D-serine
OT  - NMDA
OT  - astrocyte
OT  - excitatory postsynaptic current
OT  - field potential
OT  - glial fibrillary acidic protein
OT  - hippocampus
OT  - long-term potentiation
OT  - temporal lobe epilepsy
COIS- The authors declare no conflict of interest.
EDAT- 2021/12/25 06:00
MHDA- 2022/01/11 06:00
PMCR- 2021/12/12
CRDT- 2021/12/24 01:16
PHST- 2021/11/02 00:00 [received]
PHST- 2021/12/06 00:00 [revised]
PHST- 2021/12/10 00:00 [accepted]
PHST- 2021/12/24 01:16 [entrez]
PHST- 2021/12/25 06:00 [pubmed]
PHST- 2022/01/11 06:00 [medline]
PHST- 2021/12/12 00:00 [pmc-release]
AID - ijms222413355 [pii]
AID - ijms-22-13355 [pii]
AID - 10.3390/ijms222413355 [doi]
PST - epublish
SO  - Int J Mol Sci. 2021 Dec 12;22(24):13355. doi: 10.3390/ijms222413355.