PMID- 34948498
OWN - NLM
STAT- MEDLINE
DCOM- 20211231
LR  - 20220531
IS  - 1660-4601 (Electronic)
IS  - 1661-7827 (Print)
IS  - 1660-4601 (Linking)
VI  - 18
IP  - 24
DP  - 2021 Dec 7
TI  - Direct and Indirect Effects of Indoor Particulate Matter on Blood Indicators 
      Related to Anemia.
LID - 10.3390/ijerph182412890 [doi]
LID - 12890
AB  - Exposure to indoor particulate matter (PM) is a potential risk factor that 
      increases systemic inflammation and affects erythropoiesis. This study 
      investigated the association between exposure to indoor PM and blood indicators 
      related to anemia (BIRA) in housewives. Indoor PM and blood folate status are 
      important factors in the risk of anemia. This was a housewife cohort study; we 
      recruited 284 housewives in Seoul and Ulsan, Republic of Korea. Indoor exposure 
      to PM2.5 and PM10 was measured by gravimetric analysis and sensors. We 
      investigated the BIRA, such as hemoglobin (Hb), hematocrit, mean corpuscular 
      volume (MCV), mean corpuscular Hb (MCH), and mean corpuscular Hb concentration 
      (MCHC). Statistical analysis was performed by multiple linear regression model 
      and mediation analysis. The association between BIRA and PM was assessed by 
      multiple linear regression models fitted by mediation analyses. The increase in 
      the level of indoor PM2.5 was associated with a decrease in MCV (Beta coefficient 
      (B): -0.069, Standard error (SE): 0.022) and MCH (B: -0.019, SE: 0.009) in 
      gravimetric measurements. The increase in the level of indoor PM2.5 was 
      associated with a decrease in Hb (B: -0.024, SE: 0.011), hematocrit (B: -0.059, 
      SE: 0.033), and MCV (B: -0.081, SE: 0.037) and MCH (B: -0.037, SE: 0.012) in 
      sensor measurements (PM2.5-Lag10). Further, we identified a serum folate-mediated 
      PM effect. The indoor PM exposure was significantly associated with decreased Hb, 
      MCV, and MCH in housewives. Taken together, our data show that exposure to indoor 
      PM is a risk factor for anemia in housewives. Blood folate concentration can be a 
      mediating factor in the effect of indoor PM on BIRA. Therefore, folate intake 
      should be recommended to prevent anemia in housewives. Moreover, indoor PM 
      exposure should be managed.
FAU - Kwag, Youngrin
AU  - Kwag Y
AUID- ORCID: 0000-0002-3231-2493
AD  - Department of Environmental Medicine, School of Medicine, Ewha Womans University, 
      Seoul KS013, Korea.
AD  - Graduate Program in System Health Science and Engineering, Ewha Womans 
      University, Seoul KS013, Korea.
FAU - Ye, Shinhee
AU  - Ye S
AD  - Occupational Safety and Health Research Institute, Korea Occupational Safety and 
      Health Agency, Incheon KS006, Korea.
FAU - Oh, Jongmin
AU  - Oh J
AUID- ORCID: 0000-0002-2980-6943
AD  - Department of Environmental Medicine, School of Medicine, Ewha Womans University, 
      Seoul KS013, Korea.
FAU - Lee, Dong-Wook
AU  - Lee DW
AUID- ORCID: 0000-0002-4023-3269
AD  - Department of Preventive Medicine, College of Medicine, Seoul National 
      University, Seoul KS013, Korea.
FAU - Yang, Wonho
AU  - Yang W
AUID- ORCID: 0000-0003-2776-5989
AD  - Department of Occupational Health, Daegu Catholic University, Gyeongsan-si KS002, 
      Korea.
FAU - Kim, Yangho
AU  - Kim Y
AUID- ORCID: 0000-0002-6462-0829
AD  - Department of Occupational and Environmental Medicine, Ulsan University Hospital, 
      University of Ulsan College of Medicine, Ulsan KS016, Korea.
FAU - Ha, Eunhee
AU  - Ha E
AD  - Department of Environmental Medicine, School of Medicine, Ewha Womans University, 
      Seoul KS013, Korea.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20211207
PL  - Switzerland
TA  - Int J Environ Res Public Health
JT  - International journal of environmental research and public health
JID - 101238455
RN  - 0 (Air Pollutants)
RN  - 0 (Particulate Matter)
SB  - IM
MH  - *Air Pollutants/analysis/toxicity
MH  - *Air Pollution, Indoor/analysis/statistics & numerical data
MH  - *Anemia/chemically induced/epidemiology
MH  - Cohort Studies
MH  - Erythrocyte Indices
MH  - Hematocrit
MH  - Humans
MH  - Particulate Matter/analysis/toxicity
PMC - PMC8701383
OTO - NOTNLM
OT  - Hb
OT  - MCH
OT  - MCHC
OT  - MCV
OT  - folate
OT  - housewives
OT  - indoor particulate matter
COIS- The authors declare no conflict of interest.
EDAT- 2021/12/25 06:00
MHDA- 2022/01/01 06:00
PMCR- 2021/12/07
CRDT- 2021/12/24 01:18
PHST- 2021/11/23 00:00 [received]
PHST- 2021/11/30 00:00 [revised]
PHST- 2021/11/30 00:00 [accepted]
PHST- 2021/12/24 01:18 [entrez]
PHST- 2021/12/25 06:00 [pubmed]
PHST- 2022/01/01 06:00 [medline]
PHST- 2021/12/07 00:00 [pmc-release]
AID - ijerph182412890 [pii]
AID - ijerph-18-12890 [pii]
AID - 10.3390/ijerph182412890 [doi]
PST - epublish
SO  - Int J Environ Res Public Health. 2021 Dec 7;18(24):12890. doi: 
      10.3390/ijerph182412890.