PMID- 34949295
OWN - NLM
STAT- MEDLINE
DCOM- 20220221
LR  - 20220221
IS  - 2078-5135 (Electronic)
VI  - 111
IP  - 10
DP  - 2021 Oct 5
TI  - The prevalence of coeliac disease-associated human leukocyte antigens in South 
      African transplant donors and recipients.
PG  - 991-994
LID - 10.7196/SAMJ.2021.v111i10.15680 [doi]
AB  - BACKGROUND: Coeliac disease (CD) is an autoimmune condition occurring in 
      genetically predisposed individuals exposed to an environmental trigger. The 
      human leukocyte antigen (HLA) haplotypes HLA-DQ2.5 and HLA-DQ8 have the strongest 
      association with CD, and 90 - 95% of CD patients bear these haplotypes. The 
      susceptibility of the South African (SA) population to CD has not been studied 
      previously. OBJECTIVES: To describe the genetic propensity of the SA population 
      to CD. METHODS: The South African National Blood Service database was used to 
      analyse the prevalence of HLA-DQ2.5 and HLA-DQ8 in potential donors and 
      recipients of organ transplants. Self-reported ethnic group was used to estimate 
      the prevalence among different population groups. RESULTS: The overall prevalence 
      of HLA-DQ2.5 and HLA-DQ8 was 19.8%. The prevalence was lower in black 
      participants (15.9%) than in whites (28.6%). Coloured (22.0%) and Indian (17.4%) 
      participants had an intermediate prevalence. There was no significant difference 
      between potential transplant donors and recipients. CONCLUSIONS: The prevalence 
      of HLA-DQ2.5 and HLA-DQ8 differed among SA study participants of different 
      ethnicities. However, the notion that CD does not occur in black South Africans 
      owing to lack of a genetic predisposition is incorrect.
FAU - Mrubata, K L
AU  - Mrubata KL
AD  - Department of Paediatrics, Rahima Moosa Mother and Child Hospital and Department 
      of Paediatrics and Child Health, School of Clinical Medicine, Faculty of Health 
      Sciences, University of the Witwatersrand, Johannesburg, South Africa. 
      mrbkit001@gmail.com.
FAU - Barrow, P
AU  - Barrow P
FAU - Mayne, E
AU  - Mayne E
FAU - Nelson, D
AU  - Nelson D
FAU - De Maayer, T
AU  - De Maayer T
LA  - eng
PT  - Journal Article
DEP - 20211005
PL  - South Africa
TA  - S Afr Med J
JT  - South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde
JID - 0404520
RN  - 0 (HLA-DQ Antigens)
RN  - 0 (HLA-DQ2 antigen)
RN  - 0 (HLA-DQ8 antigen)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Celiac Disease/epidemiology/ethnology/*genetics
MH  - Child
MH  - Child, Preschool
MH  - Female
MH  - Genetic Predisposition to Disease
MH  - HLA-DQ Antigens/*genetics
MH  - Haplotypes/genetics
MH  - Humans
MH  - Infant
MH  - Infant, Newborn
MH  - Male
MH  - Middle Aged
MH  - Prevalence
MH  - South Africa/epidemiology
MH  - *Tissue Donors
MH  - *Transplant Recipients
EDAT- 2021/12/25 06:00
MHDA- 2022/02/22 06:00
CRDT- 2021/12/24 05:25
PHST- 2021/10/05 00:00 [received]
PHST- 2021/12/24 05:25 [entrez]
PHST- 2021/12/25 06:00 [pubmed]
PHST- 2022/02/22 06:00 [medline]
AID - 10.7196/SAMJ.2021.v111i10.15680 [doi]
PST - epublish
SO  - S Afr Med J. 2021 Oct 5;111(10):991-994. doi: 10.7196/SAMJ.2021.v111i10.15680.