PMID- 34950365
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220429
IS  - 1941-6911 (Print)
IS  - 1941-6911 (Electronic)
IS  - 1941-6911 (Linking)
VI  - 14
IP  - 1
DP  - 2021 Jun-Jul
TI  - Active Implantable cardioverter-defibrillators in Continuous-flow Left 
      Ventricular Assist Device Recipients.
PG  - 20200490
LID - 10.4022/jafib.20200490 [doi]
LID - 20200490
AB  - INTRODUCTION: Implantable cardioverter-defibrillator (ICD) in patients with heart 
      failure with reduced ejection fraction reduces mortality secondary to malignant 
      arrhythmias. Whether end-stage heart failure (HF) with continuous-flow left 
      ventricular assist device (cf-LVAD) derive similar benefits remains 
      controversial. METHODS: We performed a systematic literature review and 
      meta-analysis of all published studies that examined the association between 
      active ICDs and survival in advanced HF patients with cfLVAD. We searched PubMed, 
      Medline, Embase, Ovid, and Cochrane for studies reporting the association between 
      ICD and all-cause mortality in advanced HF patients with cfLVAD. Mantel-Haenszel 
      risk ratio (RR) random-effects model was used to summarize data. RESULTS: Ten 
      studies (9 retrospective and one prospective) with a total of 7,091 patients met 
      inclusion criteria. There was no difference in all-cause mortality (RR 0.84, 95% 
      CI 0.65-1.10, p=0.20, I(2) =62.40%), likelihood of survival to transplant (RR 
      1.07, 95% CI 0.98-1.17, p= 0.13, I(2) =0%), RV failure (RR 0.74, 95% CI 
      0.44-1.25, p = 0.26, I(2) =34%) between Active ICD and inactive/no ICD groups, 
      respectively. Additionally, 27.5% received appropriate ICD shocks, while 9.5% 
      received inappropriate ICD shocks. No significant difference was observed in 
      terms of any complications between the two groups. CONCLUSIONS: All-cause 
      mortality, the likelihood of survival to transplant, and worsening RV failure 
      were not significantly different between active ICD and inactive/no ICD in 
      cf-LVAD recipients. A substantial number of patients received appropriate ICD 
      shocks suggesting a high-arrhythmia burden. The risks and benefits of ICDs must 
      be carefully considered in patients with cf-LVAD.
FAU - Shah, Kuldeep
AU  - Shah K
AD  - Division of Cardiology, Cardiac Arrhythmia Service, Beaumont Hospital, Oakland 
      University William Beaumont School of Medicine, Royal Oak, Michigan.
FAU - Chaudhary, Rahul
AU  - Chaudhary R
AD  - Division of Cardiology, University of Pittsburgh Medical Center, Pittsburgh, PA.
FAU - K Turagam, Mohit
AU  - K Turagam M
AD  - Helmsley Electrophysiology Center, Icahn School of Medicine at Mount Sinai, New 
      York, NY.
FAU - Shah, Mahek
AU  - Shah M
AD  - Division of Cardiology, Thomas Jefferson University Hospital, Philadelphia, PA.
FAU - Patel, Brijesh
AU  - Patel B
AD  - Division of Cardiology, West Virginia University Medical Center, Morgantown, VW.
FAU - Lanier, Gregg
AU  - Lanier G
AD  - Division of Cardiology, Westchester Medical Center, New York Medical College, 
      Valhalla, NY.
FAU - Lakkireddy, Dhanunjaya
AU  - Lakkireddy D
AD  - Cardiac Arrhythmia Service, Kansas City Heart Rhythm Institute and Research 
      Foundation, Kansas City, KS.
AD  - DL and JG are co-senior authors.
FAU - Garg, Jalaj
AU  - Garg J
AD  - Division of Cardiology, Cardiac Arrhythmia Service, Loma Linda University Health, 
      Loma Linda, CA.
AD  - DL and JG are co-senior authors.
LA  - eng
PT  - Journal Article
DEP - 20210630
PL  - United States
TA  - J Atr Fibrillation
JT  - Journal of atrial fibrillation
JID - 101514767
PMC - PMC8691323
OTO - NOTNLM
OT  - Continuous-flow LVAD
OT  - Implantable cardioverter-defibrillator
OT  - Mortality
EDAT- 2021/12/25 06:00
MHDA- 2021/12/25 06:01
PMCR- 2021/06/30
CRDT- 2021/12/24 05:49
PHST- 2021/03/26 00:00 [received]
PHST- 2021/04/20 00:00 [revised]
PHST- 2021/06/26 00:00 [accepted]
PHST- 2021/12/24 05:49 [entrez]
PHST- 2021/12/25 06:00 [pubmed]
PHST- 2021/12/25 06:01 [medline]
PHST- 2021/06/30 00:00 [pmc-release]
AID - 10.4022/jafib.20200490 [doi]
PST - epublish
SO  - J Atr Fibrillation. 2021 Jun 30;14(1):20200490. doi: 10.4022/jafib.20200490. 
      eCollection 2021 Jun-Jul.