PMID- 34950781
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220429
IS  - 2397-9070 (Electronic)
IS  - 2397-9070 (Linking)
VI  - 5
IP  - 12
DP  - 2021 Dec
TI  - Factors associated with time to clinical remission in pediatric luminal Crohn's 
      disease: A retrospective cohort study.
PG  - 1373-1381
LID - 10.1002/jgh3.12684 [doi]
AB  - BACKGROUND AND AIM: Data on factors influencing time to remission in pediatric 
      Crohn's disease (CD) are very limited in the literature. The aim of this 
      retrospective cohort study was to describe the trends of time to clinical 
      remission over the past decade and to identify factors associated with time to 
      clinical remission in children with luminal CD. METHODS: Patients under 18 years 
      old diagnosed between 2009 and 2019 were included. All data were collected from 
      the patients' medical records. Survival analyses and linear regression models 
      were used to assess the impact of clinical, laboratory, endoscopic, histological, 
      and therapeutic factors on time to clinical remission. RESULTS: A total of 654 
      patients were included in the study. There was no change in the time to clinical 
      remission over the decade. Female sex in adolescents (adjusted beta regression 
      coefficient [abeta] = 31.8 days, P = 0.02), upper digestive tract involvement 
      (abeta = 46.4 days, P = 0.04) perianal disease (abeta = 32.2 days, P = 0.04), presence 
      of active inflammation on biopsies at diagnosis (abeta = 46.7 days, P = 0.01) and 
      oral 5-aminosalicylates (5-ASA) exposure (abeta = 56.6 days, P = 0.002) were 
      associated with longer time to clinical remission. Antibiotic exposure 
      (abeta = -29.3 days, P = 0.04), increased eosinophils (abeta = -29.6 days, P = 0.008) 
      and combination of exclusive enteral nutrition with tumor-necrosis-factor-alpha 
      (TNF-alpha) inhibitors as induction therapy (abeta = -36.8 days, P = 0.04) were 
      associated with shorter time to clinical remission. CONCLUSION: In children with 
      newly diagnosed Crohn's disease, time to clinical remission did not shorten 
      during the decade. It was associated with baseline clinical and histological data 
      and treatment strategies. Combination of enteral nutrition and TNF-alpha 
      inhibitors was associated with faster clinical remission.
CI  - (c) 2021 The Authors. JGH Open published by Journal of Gastroenterology and 
      Hepatology Foundation and John Wiley & Sons Australia, Ltd.
FAU - Sassine, Samuel
AU  - Sassine S
AUID- ORCID: 0000-0002-6175-7547
AD  - CHU Sainte-Justine Research Center Montreal Quebec Canada.
AD  - Faculty of Medicine Universite de Montreal Montreal Quebec Canada.
FAU - Zekhnine, Souhila
AU  - Zekhnine S
AD  - CHU Sainte-Justine Research Center Montreal Quebec Canada.
AD  - Faculty of Medicine Universite de Montreal Montreal Quebec Canada.
FAU - Qaddouri, Marwa
AU  - Qaddouri M
AD  - CHU Sainte-Justine Research Center Montreal Quebec Canada.
AD  - Faculty of Medicine Universite de Montreal Montreal Quebec Canada.
FAU - Djani, Lisa
AU  - Djani L
AD  - CHU Sainte-Justine Research Center Montreal Quebec Canada.
AD  - Faculty of Medicine Universite de Montreal Montreal Quebec Canada.
FAU - Cambron-Asselin, Christine
AU  - Cambron-Asselin C
AD  - CHU Sainte-Justine Research Center Montreal Quebec Canada.
AD  - Faculty of Medicine Universite de Montreal Montreal Quebec Canada.
FAU - Savoie-Robichaud, Mathieu
AU  - Savoie-Robichaud M
AD  - CHU Sainte-Justine Research Center Montreal Quebec Canada.
AD  - Faculty of Medicine Universite de Montreal Montreal Quebec Canada.
FAU - Lin, Yi Fan
AU  - Lin YF
AD  - CHU Sainte-Justine Research Center Montreal Quebec Canada.
AD  - Faculty of Medicine Universite de Montreal Montreal Quebec Canada.
FAU - Grzywacz, Kelly
AU  - Grzywacz K
AD  - CHU Sainte-Justine Research Center Montreal Quebec Canada.
AD  - Faculty of Medicine Universite de Montreal Montreal Quebec Canada.
AD  - Division of Gastroenterology, Department of Pediatrics CHU Sainte-Justine 
      Montreal Quebec Canada.
FAU - Groleau, Veronique
AU  - Groleau V
AD  - CHU Sainte-Justine Research Center Montreal Quebec Canada.
AD  - Faculty of Medicine Universite de Montreal Montreal Quebec Canada.
AD  - Division of Gastroenterology, Department of Pediatrics CHU Sainte-Justine 
      Montreal Quebec Canada.
FAU - Dirks, Martha
AU  - Dirks M
AD  - Faculty of Medicine Universite de Montreal Montreal Quebec Canada.
AD  - Division of Gastroenterology, Department of Pediatrics CHU Sainte-Justine 
      Montreal Quebec Canada.
FAU - Drouin, Eric
AU  - Drouin E
AD  - CHU Sainte-Justine Research Center Montreal Quebec Canada.
AD  - Faculty of Medicine Universite de Montreal Montreal Quebec Canada.
AD  - Division of Gastroenterology, Department of Pediatrics CHU Sainte-Justine 
      Montreal Quebec Canada.
FAU - Halac, Ugur
AU  - Halac U
AD  - Faculty of Medicine Universite de Montreal Montreal Quebec Canada.
AD  - Division of Gastroenterology, Department of Pediatrics CHU Sainte-Justine 
      Montreal Quebec Canada.
FAU - Marchand, Valerie
AU  - Marchand V
AD  - Faculty of Medicine Universite de Montreal Montreal Quebec Canada.
AD  - Division of Gastroenterology, Department of Pediatrics CHU Sainte-Justine 
      Montreal Quebec Canada.
FAU - Girard, Chloe
AU  - Girard C
AD  - CHU Sainte-Justine Research Center Montreal Quebec Canada.
AD  - Faculty of Medicine Universite de Montreal Montreal Quebec Canada.
AD  - Division of Gastroenterology, Department of Pediatrics CHU Sainte-Justine 
      Montreal Quebec Canada.
FAU - Courbette, Olivier
AU  - Courbette O
AD  - CHU Sainte-Justine Research Center Montreal Quebec Canada.
AD  - Faculty of Medicine Universite de Montreal Montreal Quebec Canada.
AD  - Division of Gastroenterology, Department of Pediatrics CHU Sainte-Justine 
      Montreal Quebec Canada.
FAU - Patey, Natalie
AU  - Patey N
AD  - CHU Sainte-Justine Research Center Montreal Quebec Canada.
AD  - Faculty of Medicine Universite de Montreal Montreal Quebec Canada.
AD  - Department of Pathology CHU Sainte-Justine Montreal Quebec Canada.
FAU - Dal Soglio, Dorothee
AU  - Dal Soglio D
AD  - CHU Sainte-Justine Research Center Montreal Quebec Canada.
AD  - Faculty of Medicine Universite de Montreal Montreal Quebec Canada.
AD  - Department of Pathology CHU Sainte-Justine Montreal Quebec Canada.
FAU - Deslandres, Colette
AU  - Deslandres C
AD  - CHU Sainte-Justine Research Center Montreal Quebec Canada.
AD  - Faculty of Medicine Universite de Montreal Montreal Quebec Canada.
AD  - Division of Gastroenterology, Department of Pediatrics CHU Sainte-Justine 
      Montreal Quebec Canada.
FAU - Jantchou, Prevost
AU  - Jantchou P
AUID- ORCID: 0000-0002-8907-5687
AD  - CHU Sainte-Justine Research Center Montreal Quebec Canada.
AD  - Faculty of Medicine Universite de Montreal Montreal Quebec Canada.
AD  - Division of Gastroenterology, Department of Pediatrics CHU Sainte-Justine 
      Montreal Quebec Canada.
LA  - eng
PT  - Journal Article
DEP - 20211127
PL  - Australia
TA  - JGH Open
JT  - JGH open : an open access journal of gastroenterology and hepatology
JID - 101730833
PMC - PMC8674552
OTO - NOTNLM
OT  - Crohn's disease
OT  - TNF-alpha inhibitors
OT  - clinical remission
OT  - exclusive enteral nutrition
OT  - pediatrics
EDAT- 2021/12/25 06:00
MHDA- 2021/12/25 06:01
PMCR- 2021/11/27
CRDT- 2021/12/24 05:54
PHST- 2021/09/06 00:00 [received]
PHST- 2021/11/10 00:00 [accepted]
PHST- 2021/12/24 05:54 [entrez]
PHST- 2021/12/25 06:00 [pubmed]
PHST- 2021/12/25 06:01 [medline]
PHST- 2021/11/27 00:00 [pmc-release]
AID - JGH312684 [pii]
AID - 10.1002/jgh3.12684 [doi]
PST - epublish
SO  - JGH Open. 2021 Nov 27;5(12):1373-1381. doi: 10.1002/jgh3.12684. eCollection 2021 
      Dec.