PMID- 34951987
OWN - NLM
STAT- MEDLINE
DCOM- 20220331
LR  - 20230416
IS  - 1096-0953 (Electronic)
IS  - 0013-9351 (Print)
IS  - 0013-9351 (Linking)
VI  - 206
DP  - 2022 Apr 15
TI  - The relationship between persistent organic pollutants and Attention Deficit 
      Hyperactivity Disorder phenotypes: Evidence from task-based neural activity in an 
      observational study of a community sample of Canadian mother-child dyads.
PG  - 112593
LID - S0013-9351(21)01894-6 [pii]
LID - 10.1016/j.envres.2021.112593 [doi]
AB  - BACKGROUND: Prenatal exposure to persistent organic pollutants (POPs), widespread 
      in North America, is associated with increased Attention Deficit/Hyperactivity 
      Disorder (ADHD) symptoms and may be a modifiable risk for ADHD phenotypes. 
      However, the effects of moderate exposure to POPs on task-based inhibitory 
      control performance, related brain function, and ADHD-related symptoms remain 
      unknown, limiting our ability to develop interventions targeting the neural 
      impact of common levels of exposure. OBJECTIVES: The goal of this study was to 
      examine the association between prenatal POP exposure and inhibitory control 
      performance, neural correlates of inhibitory control and ADHD-related symptoms. 
      METHODS: Prospective data was gathered in an observational study of Canadian 
      mother-child dyads, with moderate exposure to POPs, including polychlorinated 
      biphenyls (PCBs) and polybrominated diphenyl ethers (PBDEs), as part of the 
      GESTation and the Environment (GESTE) cohort in Sherbrooke, Quebec, Canada. The 
      sample included 87 eligible children, 46 with maternal plasma samples, functional 
      magnetic resonance imaging (fMRI) data of Simon task performance at 9-11 years, 
      and parental report of clinical symptoms via the Behavioral Assessment System for 
      Children 3 (BASC-3). Simon task performance was probed via drift diffusion 
      modeling, and parameter estimates were related to POP exposure. Simon task-based 
      fMRI data was modeled to examine the difference in incongruent vs congruent 
      trials in regions of interest (ROIs) identified by meta analysis. RESULTS: Of the 
      46 participants with complete data, 29 were male, and mean age was 10.42 +/- 0.55 
      years. Increased POP exposure was associated with reduced accuracy (e.g. PCB 
      molar sum rate ratio = 0.95; 95% CI [0.90, 0.99]), drift rate (e.g. for PCB molar 
      sum beta = -0.42; 95% CI [-0.77, -0.07]), and task-related brain activity (e.g. in 
      inferior frontal cortex for PCB molar sum beta = -0.35; 95% CI [-0.69, -0.02]), and 
      increased ADHD symptoms (e.g. hyperactivity PCB molar sum beta = 2.35; 95%CI [0.17, 
      4.53]), supporting the possibility that prenatal exposure to POPs is a modifiable 
      risk for ADHD phenotypes. DISCUSSION: We showed that exposure to POPs is related 
      to task-based changes in neural activity in brain regions important for 
      inhibitory control, suggesting a biological mechanism underlying previously 
      documented associations between POPs and neurobehavioral deficits found in ADHD 
      phenotypes.
CI  - Copyright (c) 2021 Elsevier Inc. All rights reserved.
FAU - Sussman, Tamara J
AU  - Sussman TJ
AD  - New York State Psychiatric Institute, New York, NY, USA; Department of 
      Psychiatry, Columbia University Medical Center, New York, NY, USA.
FAU - Baker, Brennan H
AU  - Baker BH
AD  - Department of Environmental Health Sciences, Columbia University Mailman School 
      of Public Health, New York, NY, USA.
FAU - Wakhloo, Albert J
AU  - Wakhloo AJ
AD  - New York State Psychiatric Institute, New York, NY, USA.
FAU - Gillet, Virginie
AU  - Gillet V
AD  - Departement de Pediatrie, Faculte de Medecine et des Sciences de La Sante, 
      Universite de Sherbrooke, Sherbrooke, Quebec, Canada.
FAU - Abdelouahab, Nadia
AU  - Abdelouahab N
AD  - Departement de Pediatrie, Faculte de Medecine et des Sciences de La Sante, 
      Universite de Sherbrooke, Sherbrooke, Quebec, Canada.
FAU - Whittingstall, Kevin
AU  - Whittingstall K
AD  - Department of Nuclear Medicine and Radiobiology, Faculty of Medicine and Health 
      Science, Universite de Sherbrooke, Sherbrooke, Quebec, Canada; Department of 
      Diagnostic Radiology, Faculty of Medicine and Health Science, Universite de 
      Sherbrooke, Sherbrooke, Quebec, Canada.
FAU - Lepage, Jean-Francois
AU  - Lepage JF
AD  - Departement de Pediatrie, Faculte de Medecine et des Sciences de La Sante, 
      Universite de Sherbrooke, Sherbrooke, Quebec, Canada.
FAU - St-Cyr, Lindsay
AU  - St-Cyr L
AD  - Departement de Pediatrie, Faculte de Medecine et des Sciences de La Sante, 
      Universite de Sherbrooke, Sherbrooke, Quebec, Canada.
FAU - Boivin, Amelie
AU  - Boivin A
AD  - Departement de Pediatrie, Faculte de Medecine et des Sciences de La Sante, 
      Universite de Sherbrooke, Sherbrooke, Quebec, Canada.
FAU - Gagnon, Anthony
AU  - Gagnon A
AD  - Departement de Pediatrie, Faculte de Medecine et des Sciences de La Sante, 
      Universite de Sherbrooke, Sherbrooke, Quebec, Canada.
FAU - Baccarelli, Andrea A
AU  - Baccarelli AA
AD  - Department of Environmental Health Sciences, Columbia University Mailman School 
      of Public Health, New York, NY, USA.
FAU - Takser, Larissa
AU  - Takser L
AD  - Departement de Pediatrie, Faculte de Medecine et des Sciences de La Sante, 
      Universite de Sherbrooke, Sherbrooke, Quebec, Canada; Departement de Psychiatrie, 
      Faculte de Medecine et des Sciences de La Sante, Universite de Sherbrooke, 
      Sherbrooke, Quebec, Canada. Electronic address: larissa.takser@usherbrooke.ca.
FAU - Posner, Jonathan
AU  - Posner J
AD  - New York State Psychiatric Institute, New York, NY, USA; Department of 
      Psychiatry, Columbia University Medical Center, New York, NY, USA.
LA  - eng
GR  - K08 DA049913/DA/NIDA NIH HHS/United States
GR  - R01 ES027845/ES/NIEHS NIH HHS/United States
GR  - R01 MH119510/MH/NIMH NIH HHS/United States
PT  - Journal Article
PT  - Meta-Analysis
PT  - Research Support, N.I.H., Extramural
DEP - 20211222
PL  - Netherlands
TA  - Environ Res
JT  - Environmental research
JID - 0147621
RN  - 0 (Environmental Pollutants)
RN  - DFC2HB4I0K (Polychlorinated Biphenyls)
SB  - IM
MH  - *Attention Deficit Disorder with Hyperactivity/chemically induced/epidemiology
MH  - Canada/epidemiology
MH  - *Environmental Pollutants
MH  - Female
MH  - Humans
MH  - Male
MH  - Maternal Exposure
MH  - Mother-Child Relations
MH  - Observational Studies as Topic
MH  - Persistent Organic Pollutants
MH  - Phenotype
MH  - *Polychlorinated Biphenyls
MH  - Pregnancy
MH  - *Prenatal Exposure Delayed Effects/chemically induced/epidemiology
MH  - Prospective Studies
PMC - PMC9004716
MID - NIHMS1785625
OTO - NOTNLM
OT  - Attention deficit hyperactivity disorder (ADHD)
OT  - Functional magnetic resonance imaging (fMRI)
OT  - Inhibitory control
OT  - Persistent organic pollutants (POPs)
OT  - Polybrominated diphenyl ethers (PBDEs)
OT  - Polychlorinated biphenyls (PCBs)
COIS- Declaration of competing interest The authors declare that they have no known 
      competing financial interests or personal relationships that could have appeared 
      to influence the work reported in this paper.
EDAT- 2021/12/25 06:00
MHDA- 2022/04/01 06:00
PMCR- 2023/04/15
CRDT- 2021/12/24 20:08
PHST- 2021/09/28 00:00 [received]
PHST- 2021/12/10 00:00 [revised]
PHST- 2021/12/16 00:00 [accepted]
PHST- 2021/12/25 06:00 [pubmed]
PHST- 2022/04/01 06:00 [medline]
PHST- 2021/12/24 20:08 [entrez]
PHST- 2023/04/15 00:00 [pmc-release]
AID - S0013-9351(21)01894-6 [pii]
AID - 10.1016/j.envres.2021.112593 [doi]
PST - ppublish
SO  - Environ Res. 2022 Apr 15;206:112593. doi: 10.1016/j.envres.2021.112593. Epub 2021 
      Dec 22.