PMID- 34952121
OWN - NLM
STAT- MEDLINE
DCOM- 20220304
LR  - 20220304
IS  - 1573-2517 (Electronic)
IS  - 0165-0327 (Linking)
VI  - 300
DP  - 2022 Mar 1
TI  - How sleep disturbances affect internet gaming disorder: The mediating effect of 
      hippocampal functional connectivity.
PG  - 84-90
LID - S0165-0327(21)01403-8 [pii]
LID - 10.1016/j.jad.2021.12.085 [doi]
AB  - BACKGROUND: Studies have revealed that sleep disturbances lead to an increased 
      risk of Internet gaming disorder (IGD). However, the neural underpinnings of this 
      feature remain unknown. Exploring this issue would be valuable in understanding 
      the relationship between sleep and psychiatric disorders. METHODS: Given the 
      impact of sleep on reward circuitry, we examined nucleus accumbens (NAcc) and 
      hippocampal resting-state functional connectivity (rsFC) differences between 41 
      IGD subjects and 59 healthy controls. Significant connections were determined and 
      used to examine correlations with clinical variables. Finally, we explored the 
      relationship between neuroimaging findings, IGD severity and sleep disturbances 
      through a mediation model. RESULTS: We observed the connection deviation between 
      the hippocampus and a wide range of cerebral cortexes in IGD subjects, including 
      the prefrontal, parietal and temporal lobes. More importantly, the right 
      posterior hippocampus (pHIP)-left caudate rsFC was positively correlated with 
      both the Pittsburgh Sleep Quality Index (PSQI) and Internet Addiction Test scores 
      and mediated the relationship between the two. For the NAcc, a difference between 
      groups was only observed in the rsFC between the shell partition of the NAcc and 
      the inferior orbitofrontal cortex, but this connectivity was not related to the 
      PSQI score. CONCLUSIONS: IGD subjects showed a wide range of abnormal connections 
      in the hippocampus, involving memory, reward motivation, and cognitive control. 
      Here we emphasized the potential of the hippocampus in studying sleep 
      disturbances in IGD, especially the coupling between the pHIP and caudate 
      nucleus, which could provide novel insight into how sleep interacts with 
      motivational systems in IGD subjects.
CI  - Copyright (c) 2021 Elsevier B.V. All rights reserved.
FAU - Zheng, Hui
AU  - Zheng H
AD  - Center for Cognition and Brain Disorders, the Affiliated Hospital of Hangzhou 
      Normal University, Hangzhou, P.R. China; Shanghai Key Laboratory of Psychotic 
      Disorders, Shanghai Mental Health Center, Shanghai Jiao Tong University School of 
      Medicine, Shanghai, China.
FAU - Wang, Min
AU  - Wang M
AD  - Shanghai Key Laboratory of Psychotic Disorders, Shanghai Mental Health Center, 
      Shanghai Jiao Tong University School of Medicine, Shanghai, China.
FAU - Zheng, Yanbin
AU  - Zheng Y
AD  - Shanghai Key Laboratory of Psychotic Disorders, Shanghai Mental Health Center, 
      Shanghai Jiao Tong University School of Medicine, Shanghai, China.
FAU - Dong, Guang-Heng
AU  - Dong GH
AD  - Shanghai Key Laboratory of Psychotic Disorders, Shanghai Mental Health Center, 
      Shanghai Jiao Tong University School of Medicine, Shanghai, China; Institute of 
      Psychological Science, Hangzhou Normal University, Hangzhou, P.R. China; Zhejiang 
      Key Laboratory for Research in Assessment of Cognitive Impairments, Hangzhou, 
      Zhejiang Province, P.R. China. Electronic address: dongguangheng@hznu.edu.cn.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20211222
PL  - Netherlands
TA  - J Affect Disord
JT  - Journal of affective disorders
JID - 7906073
SB  - IM
MH  - *Behavior, Addictive/diagnostic imaging
MH  - Brain Mapping/methods
MH  - Hippocampus/diagnostic imaging
MH  - Humans
MH  - Internet Addiction Disorder/diagnostic imaging
MH  - Magnetic Resonance Imaging
MH  - Sleep
MH  - *Video Games/psychology
OTO - NOTNLM
OT  - Hippocampus
OT  - Internet gaming disorder
OT  - Limbic circuits
OT  - Nucleus accumbens
OT  - Sleep
EDAT- 2021/12/25 06:00
MHDA- 2022/03/05 06:00
CRDT- 2021/12/24 20:10
PHST- 2021/06/18 00:00 [received]
PHST- 2021/11/23 00:00 [revised]
PHST- 2021/12/19 00:00 [accepted]
PHST- 2021/12/25 06:00 [pubmed]
PHST- 2022/03/05 06:00 [medline]
PHST- 2021/12/24 20:10 [entrez]
AID - S0165-0327(21)01403-8 [pii]
AID - 10.1016/j.jad.2021.12.085 [doi]
PST - ppublish
SO  - J Affect Disord. 2022 Mar 1;300:84-90. doi: 10.1016/j.jad.2021.12.085. Epub 2021 
      Dec 22.