PMID- 34952244
OWN - NLM
STAT- MEDLINE
DCOM- 20220223
LR  - 20220223
IS  - 1090-2120 (Electronic)
IS  - 0045-2068 (Linking)
VI  - 119
DP  - 2022 Feb
TI  - H(2)O(2)-Responsive amphiphilic polymer with aggregation-induced emission (AIE) 
      for DOX delivery and tumor therapy.
PG  - 105559
LID - S0045-2068(21)00937-8 [pii]
LID - 10.1016/j.bioorg.2021.105559 [doi]
AB  - Stimuli-responsive drug delivery systems (DDSs) based on amphiphilic polymers 
      have attracted much attention. In this study, we reported an innovative 
      H(2)O(2)-responsive amphiphilic polymer (TBP), bearing a H(2)O(2)-sensitive 
      phenylboronic ester, AIE fluorophore tetraphenylethene (TPE) hydrophobic, and 
      polyethylene glycol hydrophilic (PEG) moieties. TBP could self-assemble into 
      micelles with an encapsulation efficiency as high as 74.9% for doxorubicin (DOX) 
      in aqueous solution. In the presence of H(2)O(2), TBP micelles was decomposed by 
      oxidation, hydrolysis and rearrangement, leading to almost 80% DOX release from 
      TBP@DOX micelles. TBP and the corresponding degradation products were 
      biocompatible, while TBP@DOX micelles only displayed obvious toxicity toward 
      cancer cells. Drug delivery process was clearly monitored by confocal laser 
      scanning microscopic (CLSM) and flow cytometry (FCM) analysis. Moreover, in vivo 
      anticancer study showed that TBP@DOX micelles were accumulated in tumor region of 
      nude mice and effectively inhibited tumor growth. The results suggested that the 
      reported H(2)O(2)-responsive amphiphilic polymer displayed great potential in 
      drug delivery and tumor therapy.
CI  - Copyright (c) 2021 Elsevier Inc. All rights reserved.
FAU - Liang, Ya-Xuan
AU  - Liang YX
AD  - College of Chemistry, Beijing Normal University, Beijing 100875, PR China.
FAU - Sun, Xue-Yi
AU  - Sun XY
AD  - College of Chemistry, Beijing Normal University, Beijing 100875, PR China.
FAU - Xu, De-Zhong
AU  - Xu DZ
AD  - China National Institute for Food and Drug Control, Institute of Chemical Drug 
      Control, TianTanXiLi 2, Beijing 100050, PR China.
FAU - Huang, Jun-Ru
AU  - Huang JR
AD  - College of Medicine, China Pharmaceutical University, Nanjing 210009, PR China.
FAU - Tang, Quan
AU  - Tang Q
AD  - College of Chemistry, Beijing Normal University, Beijing 100875, PR China.
FAU - Lu, Zhong-Lin
AU  - Lu ZL
AD  - College of Chemistry, Beijing Normal University, Beijing 100875, PR China. 
      Electronic address: luzl@bnu.edu.cn.
FAU - Liu, Rui
AU  - Liu R
AD  - College of Chemistry, Beijing Normal University, Beijing 100875, PR China. 
      Electronic address: rliu@bnu.edu.cn.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20211215
PL  - United States
TA  - Bioorg Chem
JT  - Bioorganic chemistry
JID - 1303703
RN  - 0 (Antibiotics, Antineoplastic)
RN  - 0 (Polymers)
RN  - 0 (Protein Aggregates)
RN  - 0 (Surface-Active Agents)
RN  - 80168379AG (Doxorubicin)
RN  - BBX060AN9V (Hydrogen Peroxide)
SB  - IM
MH  - Animals
MH  - Antibiotics, Antineoplastic/chemistry/*pharmacology
MH  - Cell Proliferation/drug effects
MH  - Cell Survival/drug effects
MH  - Dose-Response Relationship, Drug
MH  - Doxorubicin/chemistry/*pharmacology
MH  - *Drug Delivery Systems
MH  - Drug Liberation
MH  - Drug Screening Assays, Antitumor
MH  - Female
MH  - HEK293 Cells
MH  - HeLa Cells
MH  - Humans
MH  - Hydrogen Peroxide/*chemistry
MH  - Mice
MH  - Mice, Inbred BALB C
MH  - Mice, Nude
MH  - Molecular Structure
MH  - Polymers/*chemistry
MH  - Protein Aggregates
MH  - Structure-Activity Relationship
MH  - Surface-Active Agents/*chemistry
OTO - NOTNLM
OT  - Amphiphilic polymers
OT  - Drug delivery
OT  - H(2)O(2)-responsive
OT  - Tumor therapy
EDAT- 2021/12/25 06:00
MHDA- 2022/02/24 06:00
CRDT- 2021/12/24 20:13
PHST- 2021/10/26 00:00 [received]
PHST- 2021/12/04 00:00 [revised]
PHST- 2021/12/11 00:00 [accepted]
PHST- 2021/12/25 06:00 [pubmed]
PHST- 2022/02/24 06:00 [medline]
PHST- 2021/12/24 20:13 [entrez]
AID - S0045-2068(21)00937-8 [pii]
AID - 10.1016/j.bioorg.2021.105559 [doi]
PST - ppublish
SO  - Bioorg Chem. 2022 Feb;119:105559. doi: 10.1016/j.bioorg.2021.105559. Epub 2021 
      Dec 15.