PMID- 34952412
OWN - NLM
STAT- MEDLINE
DCOM- 20220131
LR  - 20230102
IS  - 1532-1991 (Electronic)
IS  - 0143-4160 (Print)
IS  - 0143-4160 (Linking)
VI  - 101
DP  - 2022 Jan
TI  - Structural biology of cation channels important for lysosomal calcium release.
PG  - 102519
LID - S0143-4160(21)00173-1 [pii]
LID - 10.1016/j.ceca.2021.102519 [doi]
AB  - Calcium is one of the most important second messengers in cells. The uptake and 
      release of calcium ions are conducted by channels and transporters. Inside a 
      eukaryotic cell, calcium is stored in intracellular organelles including the 
      endoplasmic reticulum (ER), mitochondrion, and lysosome. Lysosomes are acid 
      membrane-bounded organelles serving as the crucial degradation and recycling 
      center of the cell. Lysosomes involve in multiple important signaling events, 
      including nutrient sensing, lipid metabolism, and trafficking. Hitherto, two 
      lysosomal cation channel families have been suggested to function as calcium 
      release channels, namely the Two-pore Channel (TPC) family, and the Transient 
      Receptor Potential Channel Mucolipin (TRPML) family. Additionally, a few plasma 
      membrane calcium channels have also been found in the lysosomal membrane under 
      certain circumstances. In this review, we will discuss the structural mechanism 
      of the cation channels that may be important for lysosomal calcium release, 
      primarily focusing on the TPCs and TRPMLs.
CI  - Copyright (c) 2021. Published by Elsevier Ltd.
FAU - Gan, Ninghai
AU  - Gan N
AD  - Department of Physiology, University of Texas Southwestern Medical Center, 
      Dallas, TX 75390, United States of America; Department of Biophysics, University 
      of Texas Southwestern Medical Center, Dallas, Texas 75390 United States of 
      America; Howard Hughes Medical Institute, University of Texas Southwestern 
      Medical Center, Dallas, Texas 75390 United States of America.
FAU - Jiang, Youxing
AU  - Jiang Y
AD  - Department of Physiology, University of Texas Southwestern Medical Center, 
      Dallas, TX 75390, United States of America; Department of Biophysics, University 
      of Texas Southwestern Medical Center, Dallas, Texas 75390 United States of 
      America; Howard Hughes Medical Institute, University of Texas Southwestern 
      Medical Center, Dallas, Texas 75390 United States of America. Electronic address: 
      Youxing.Jiang@utsouthwestern.edu.
LA  - eng
GR  - R35 GM140892/GM/NIGMS NIH HHS/United States
GR  - HHMI/Howard Hughes Medical Institute/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20211214
PL  - Netherlands
TA  - Cell Calcium
JT  - Cell calcium
JID - 8006226
RN  - 0 (Calcium Channels)
RN  - 0 (Cations)
RN  - 0 (Transient Receptor Potential Channels)
RN  - SY7Q814VUP (Calcium)
SB  - IM
MH  - *Calcium/metabolism
MH  - Calcium Channels/metabolism
MH  - Calcium Signaling
MH  - Cations/metabolism
MH  - Humans
MH  - Lysosomes/metabolism
MH  - *Transient Receptor Potential Channels/metabolism
PMC - PMC8752501
MID - NIHMS1766468
EDAT- 2021/12/25 06:00
MHDA- 2022/02/01 06:00
PMCR- 2023/01/01
CRDT- 2021/12/24 20:22
PHST- 2021/10/05 00:00 [received]
PHST- 2021/12/10 00:00 [revised]
PHST- 2021/12/11 00:00 [accepted]
PHST- 2021/12/25 06:00 [pubmed]
PHST- 2022/02/01 06:00 [medline]
PHST- 2021/12/24 20:22 [entrez]
PHST- 2023/01/01 00:00 [pmc-release]
AID - S0143-4160(21)00173-1 [pii]
AID - 10.1016/j.ceca.2021.102519 [doi]
PST - ppublish
SO  - Cell Calcium. 2022 Jan;101:102519. doi: 10.1016/j.ceca.2021.102519. Epub 2021 Dec 
      14.