PMID- 34952622
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220107
IS  - 1758-5996 (Print)
IS  - 1758-5996 (Electronic)
IS  - 1758-5996 (Linking)
VI  - 13
IP  - 1
DP  - 2021 Dec 24
TI  - The relationship of platelet-to-lymphocyte ratio with cognitive decline in T2DM.
PG  - 151
LID - 10.1186/s13098-021-00772-y [doi]
LID - 151
AB  - PURPOSE: We aimed to investigate the role of platelet-to-lymphocyte ratio (PLR) 
      in cognitive decline in patients with type 2 diabetes mellitus (T2DM). METHODS: A 
      total number of 261 T2DM patients were enrolled in this study. The T2DM patients 
      were divided into two groups according to the median of PLR (PLR < 96.5, n = 130; 
      PLR >/= 96.5, n = 131). Cognitive impairment was defined as Mini-mental State 
      Examination score </= 26. Student's t test and Chi-square test were used to test 
      the difference between the groups, and logistics regression analysis were 
      performed to verify whether high PLR was an independent factor for cognitive 
      impairment. RESULTS: T2DM patients with cognitive impairment had significantly 
      higher PLR level when compared with the simple diabetes group (p = 0.003). 
      Incidence of cognitive impairment was higher in the high PLR group, compared to 
      low PLR group (p = 0.040). Multivariate logistic regression analysis suggested 
      that PLR was a risk biomarker of cognitive decline in T2DM patients (odds ratio 
      [OR] = 1.010, 95% CI: 1.001-1.018, p = 0.013). CONCLUSIONS: We demonstrated that 
      a higher PLR was associated with cognitive decline in T2DM patients. The PLR may 
      help to identify high-risk patients in time and provide clues for further 
      prevention of cognitive dysfunction in T2DM patients.
CI  - (c) 2021. The Author(s).
FAU - Du, Licheng
AU  - Du L
AD  - Department of Endocrinology, The Third Affiliated Hospital of Wenzhou Medical 
      University, NO.108 Wansong Road, Wenzhou, 325000, Zhejiang, China.
FAU - Hu, Xueting
AU  - Hu X
AD  - Department of Endocrinology, The Third Affiliated Hospital of Wenzhou Medical 
      University, NO.108 Wansong Road, Wenzhou, 325000, Zhejiang, China.
AD  - School of the First Clinical Medical Sciences, Wenzhou Medical University, 
      Wenzhou, China.
FAU - Zhang, Beibei
AU  - Zhang B
AD  - Department of Gastroenterology, The Third Affiliated Hospital of Wenzhou Medical 
      University, Wenzhou, China.
FAU - Miao, Xiaqi
AU  - Miao X
AD  - Department of Endocrinology, The Third Affiliated Hospital of Wenzhou Medical 
      University, NO.108 Wansong Road, Wenzhou, 325000, Zhejiang, China.
AD  - School of the First Clinical Medical Sciences, Wenzhou Medical University, 
      Wenzhou, China.
FAU - Wang, Jianing
AU  - Wang J
AD  - Department of Endocrinology, The Third Affiliated Hospital of Wenzhou Medical 
      University, NO.108 Wansong Road, Wenzhou, 325000, Zhejiang, China.
AD  - School of the First Clinical Medical Sciences, Wenzhou Medical University, 
      Wenzhou, China.
FAU - Shen, Jiamin
AU  - Shen J
AD  - Department of Endocrinology, The Third Affiliated Hospital of Wenzhou Medical 
      University, NO.108 Wansong Road, Wenzhou, 325000, Zhejiang, China.
AD  - School of the First Clinical Medical Sciences, Wenzhou Medical University, 
      Wenzhou, China.
FAU - Ding, Keke
AU  - Ding K
AD  - Department of Endocrinology, The Third Affiliated Hospital of Wenzhou Medical 
      University, NO.108 Wansong Road, Wenzhou, 325000, Zhejiang, China.
AD  - School of the First Clinical Medical Sciences, Wenzhou Medical University, 
      Wenzhou, China.
FAU - Zeng, Tian
AU  - Zeng T
AD  - Department of Endocrinology, The Third Affiliated Hospital of Wenzhou Medical 
      University, NO.108 Wansong Road, Wenzhou, 325000, Zhejiang, China.
AD  - School of the First Clinical Medical Sciences, Wenzhou Medical University, 
      Wenzhou, China.
FAU - Sun, Fangyue
AU  - Sun F
AD  - Department of Endocrinology, The Third Affiliated Hospital of Wenzhou Medical 
      University, NO.108 Wansong Road, Wenzhou, 325000, Zhejiang, China.
AD  - School of the First Clinical Medical Sciences, Wenzhou Medical University, 
      Wenzhou, China.
FAU - Yang, Hong
AU  - Yang H
AD  - Department of Endocrinology, The Third Affiliated Hospital of Wenzhou Medical 
      University, NO.108 Wansong Road, Wenzhou, 325000, Zhejiang, China. 
      yanghong7115@yeah.net.
FAU - Lin, Hai
AU  - Lin H
AUID- ORCID: 0000-0002-0358-8714
AD  - Department of Endocrinology, The Third Affiliated Hospital of Wenzhou Medical 
      University, NO.108 Wansong Road, Wenzhou, 325000, Zhejiang, China. 
      linhairy@126.com.
LA  - eng
PT  - Journal Article
DEP - 20211224
PL  - England
TA  - Diabetol Metab Syndr
JT  - Diabetology & metabolic syndrome
JID - 101488958
PMC - PMC8710029
COIS- The authors report no declarations of interest.
EDAT- 2021/12/26 06:00
MHDA- 2021/12/26 06:01
PMCR- 2021/12/24
CRDT- 2021/12/25 05:15
PHST- 2021/10/02 00:00 [received]
PHST- 2021/12/15 00:00 [accepted]
PHST- 2021/12/25 05:15 [entrez]
PHST- 2021/12/26 06:00 [pubmed]
PHST- 2021/12/26 06:01 [medline]
PHST- 2021/12/24 00:00 [pmc-release]
AID - 10.1186/s13098-021-00772-y [pii]
AID - 772 [pii]
AID - 10.1186/s13098-021-00772-y [doi]
PST - epublish
SO  - Diabetol Metab Syndr. 2021 Dec 24;13(1):151. doi: 10.1186/s13098-021-00772-y.