PMID- 34953054
OWN - NLM
STAT- MEDLINE
DCOM- 20220301
LR  - 20220301
IS  - 2050-6414 (Electronic)
IS  - 2050-6406 (Print)
IS  - 2050-6406 (Linking)
VI  - 10
IP  - 1
DP  - 2022 Feb
TI  - Endoscopic retrograde cholangiopancreatography-related adverse events in Korea: A 
      nationwide assessment.
PG  - 73-79
LID - 10.1002/ueg2.12186 [doi]
AB  - BACKGROUND: Although endoscopic retrograde cholangiopancreatography (ERCP) is a 
      pivotal procedure for the diagnosis and treatment of a variety of 
      pancreatobiliary diseases, it has been known that the risk of procedure-related 
      adverse events (AEs) is significant. OBJECTIVE: We conducted this nationwide 
      cohort study since there have been few reports on the real-world data regarding 
      ERCP-related AEs. METHODS: Patients who underwent ERCP were identified between 
      2012 and 2015 using Health Insurance Review and Assessment database generated by 
      the Korea government. Incidence, annual trends, demographics, characteristics 
      according to the types of procedures, and the risk factors of AEs were assessed. 
      RESULTS: A total of 114,757 patients with male gender of 54.2% and the mean age 
      of 65.0 +/- 15.2 years were included. The most common indication was 
      choledocholithiasis (49.4%) and the second malignant biliary obstruction (22.8%). 
      Biliary drainage (33.9%) was the most commonly performed procedure, followed by 
      endoscopic sphincterotomy (27.4%), and stone removal (22.0%). The overall 
      incidence of ERCP-related AEs was 4.7% consisting of post-ERCP pancreatitis (PEP; 
      4.6%), perforation (0.06%), and hemorrhage (0.02%), which gradually increased 
      from 2012 to 2015. According to the type of procedures, ERCP-related AEs 
      developed the most commonly after pancreatic stent insertion (11.4%), followed by 
      diagnostic ERCP (5.9%) and endoscopic sphincterotomy (5.7%). Younger age and 
      diagnostic ERCP turned out to be independent risk factors of PEP. CONCLUSIONS: 
      ERCP-related AEs developed the most commonly after pancreatic stent insertion, 
      diagnostic ERCP and endoscopic sphincterotomy. Special caution should be used for 
      young patients receiving diagnostic ERCP due to increased risk of PEP.
CI  - (c) 2021 The Authors. United European Gastroenterology Journal published by Wiley 
      Periodicals LLC on behalf of United European Gastroenterology.
FAU - Jang, Dong Kee
AU  - Jang DK
AD  - Department of Internal Medicine, Seoul Metropolitan Government Boramae Medical 
      Center, Seoul National University College of Medicine, Seoul, Korea.
FAU - Kim, Jungmee
AU  - Kim J
AD  - Department of Preventive Medicine, Seoul National University College of Medicine, 
      Seoul, Korea.
FAU - Paik, Chang Nyol
AU  - Paik CN
AUID- ORCID: 0000-0002-3470-6904
AD  - Department of Internal Medicine, College of Medicine, The Catholic University of 
      Korea, Seoul, Korea.
FAU - Kim, Jung-Wook
AU  - Kim JW
AD  - Department of Internal Medicine, Kyung Hee University Hospital, Kyung Hee 
      University College of Medicine, Seoul, Korea.
FAU - Lee, Tae Hee
AU  - Lee TH
AD  - Institute for Digestive Research, Soonchunhyang University Hospital, 
      Soonchunhyang University College of Medicine, Seoul, Korea.
FAU - Jang, Jae-Young
AU  - Jang JY
AD  - Department of Internal Medicine, Kyung Hee University Hospital, Kyung Hee 
      University College of Medicine, Seoul, Korea.
FAU - Yoon, Seung Bae
AU  - Yoon SB
AUID- ORCID: 0000-0002-6119-7236
AD  - Department of Internal Medicine, College of Medicine, The Catholic University of 
      Korea, Seoul, Korea.
FAU - Lee, Jun Kyu
AU  - Lee JK
AUID- ORCID: 0000-0002-2694-3598
AD  - Department of Internal Medicine, Dongguk University Ilsan Hospital, Dongguk 
      University College of Medicine, Goyang, Korea.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20211224
PL  - England
TA  - United European Gastroenterol J
JT  - United European gastroenterology journal
JID - 101606807
SB  - IM
CIN - United European Gastroenterol J. 2022 Feb;10(1):10-11. PMID: 35134279
MH  - Age Factors
MH  - Aged
MH  - Cholangiopancreatography, Endoscopic Retrograde/*adverse effects/statistics & 
      numerical data
MH  - Choledocholithiasis/diagnostic imaging/therapy
MH  - Cholestasis/diagnostic imaging/therapy
MH  - Cohort Studies
MH  - Databases, Factual
MH  - Drainage/statistics & numerical data
MH  - Female
MH  - Hemorrhage/*etiology
MH  - Humans
MH  - International Classification of Diseases
MH  - Male
MH  - Pancreatitis/epidemiology/*etiology
MH  - Republic of Korea
MH  - Risk Factors
MH  - Sphincterotomy, Endoscopic/adverse effects/statistics & numerical data
MH  - Stents/adverse effects
PMC - PMC8830275
OTO - NOTNLM
OT  - Korea
OT  - complication
OT  - endoscopic retrograde cholangiopancreatography
OT  - hemorrhage
OT  - pancreatitis
OT  - perforation
COIS- The authors have no conflicts of interest to declare.
EDAT- 2021/12/26 06:00
MHDA- 2022/03/03 06:00
PMCR- 2021/12/24
CRDT- 2021/12/25 05:42
PHST- 2021/09/06 00:00 [received]
PHST- 2021/11/21 00:00 [accepted]
PHST- 2021/12/26 06:00 [pubmed]
PHST- 2022/03/03 06:00 [medline]
PHST- 2021/12/25 05:42 [entrez]
PHST- 2021/12/24 00:00 [pmc-release]
AID - UEG212186 [pii]
AID - 10.1002/ueg2.12186 [doi]
PST - ppublish
SO  - United European Gastroenterol J. 2022 Feb;10(1):73-79. doi: 10.1002/ueg2.12186. 
      Epub 2021 Dec 24.