PMID- 34953656 OWN - NLM STAT- MEDLINE DCOM- 20220428 LR - 20220531 IS - 1879-0828 (Electronic) IS - 0953-6205 (Linking) VI - 97 DP - 2022 Mar TI - Interstitial pneumonia with autoimmune features: Evaluation of connective tissue disease incidence during follow-up. PG - 62-68 LID - S0953-6205(21)00432-5 [pii] LID - 10.1016/j.ejim.2021.12.021 [doi] AB - OBJECTIVES: Among interstitial pneumonia with autoimmune features (IPAF) patients, identifying those at risk to develop a connective tissue disease (CTD) during the disease course is a key issue. The aim of this study was to evaluate the incidence of definite CTD diagnosis in IPAF patients during follow-up. METHODS: We performed a multicentric cohort study of interstitial lung disease (ILD) from 2010 to 2017 in pneumology and immunology departments of tertiary care centers. Patients with a known cause of ILD (including established CTD) at diagnosis were excluded. Among patients with idiopathic ILD and at least three years of follow-up, two groups (IPAF and non-IPAF) were retrospectively analyzed at time of diagnosis. RESULTS: A total of 249 patients with ILD were enrolled, including 70 IPAF and 179 non-IPAF patients. After a mean follow-up time of 77 +/- 44 months, 18/70 IPAF patients (26%) had a CTD diagnosis - 9 antisynthetase syndrome, 8 systemic sclerosis and 1 overlap myositis - compared with 4/179 non-IPAF patients (2%). IPAF patients were at higher risk of CTD occurrence at 3 years of follow-up compared to non-IPAF patients (HR 10.1, 95% CI 3.1-33.1, p < 0. 01). IPAF patients progressing to CTD tended to be younger, more often female and have more frequently puffy fingers, capillaroscopy abnormalities and antisynthetase antibodies at diagnosis. CONCLUSIONS: We found that a significant proportion of IPAF patients had associated CTD diagnosis during follow-up. Prospective studies are needed to confirm baseline predictive factors of CTD occurrence in IPAF patients. CI - Copyright (c) 2021 European Federation of Internal Medicine. Published by Elsevier B.V. All rights reserved. FAU - Decker, Paul AU - Decker P AD - Department of Internal Medicine and Clinical Immunology, Center de Competence des Maladies Autoimmunes Systemiques Rares, CHU Nancy, University of Lorraine, 5 Rue du Morvan, Vandoeuvre-les-Nancy 54500, France. Electronic address: p.decker@chru-nancy.fr. FAU - Sobanski, Vincent AU - Sobanski V AD - Department of Internal Medicine and Clinical Immunology, Center de Reference des maladies Autoimmunes Systemiques Rares du Nord et Nord-Ouest de France (CeRAINO), CHU Lille, University of Lille, Lille F-59000, France; University of Lille, U1286 - INFINITE - Institute for Translational Research in Inflammation, Lille F-59000, France; INSERM, Lille F-59000, France; Institut Universitaire de France (IUF), France. FAU - Moulinet, Thomas AU - Moulinet T AD - Department of Internal Medicine and Clinical Immunology, Center de Competence des Maladies Autoimmunes Systemiques Rares, CHU Nancy, University of Lorraine, 5 Rue du Morvan, Vandoeuvre-les-Nancy 54500, France; UMR 7365, IMoPA, University of Lorraine, CNRS, Nancy, France. FAU - Launay, David AU - Launay D AD - Department of Internal Medicine and Clinical Immunology, Center de Reference des maladies Autoimmunes Systemiques Rares du Nord et Nord-Ouest de France (CeRAINO), CHU Lille, University of Lille, Lille F-59000, France; University of Lille, U1286 - INFINITE - Institute for Translational Research in Inflammation, Lille F-59000, France; INSERM, Lille F-59000, France. FAU - Hachulla, Eric AU - Hachulla E AD - Department of Internal Medicine and Clinical Immunology, Center de Reference des maladies Autoimmunes Systemiques Rares du Nord et Nord-Ouest de France (CeRAINO), CHU Lille, University of Lille, Lille F-59000, France; University of Lille, U1286 - INFINITE - Institute for Translational Research in Inflammation, Lille F-59000, France; INSERM, Lille F-59000, France. FAU - Valentin, Victor AU - Valentin V AD - Department of Pneumology and Immuno-Allergology, Center de Reference Constitutif Pour les Maladies Pulmonaires Rares, CHU Lille, University of Lille, Lille F-59000, France. FAU - Godbert, Benoit AU - Godbert B AD - Department of Pneumology, Metz Private Hospital, Metz, France. FAU - Revuz, Sabine AU - Revuz S AD - Department of Internal Medicine, Metz Private Hospital, Metz, France. FAU - Guillaumot, Anne AU - Guillaumot A AD - Department of Pneumology, CHU Nancy, University of Lorraine, Vandoeuvre-les-Nancy, France. FAU - Gomez, Emmanuel AU - Gomez E AD - Department of Pneumology, CHU Nancy, University of Lorraine, Vandoeuvre-les-Nancy, France. FAU - Chabot, Francois AU - Chabot F AD - Department of Pneumology, CHU Nancy, University of Lorraine, Vandoeuvre-les-Nancy, France. FAU - Wemeau, Lidwine AU - Wemeau L AD - Department of Pneumology and Immuno-Allergology, Center de Reference Constitutif Pour les Maladies Pulmonaires Rares, CHU Lille, University of Lille, Lille F-59000, France. FAU - Jaussaud, Roland AU - Jaussaud R AD - Department of Internal Medicine and Clinical Immunology, Center de Competence des Maladies Autoimmunes Systemiques Rares, CHU Nancy, University of Lorraine, 5 Rue du Morvan, Vandoeuvre-les-Nancy 54500, France. LA - eng PT - Journal Article PT - Multicenter Study DEP - 20211223 PL - Netherlands TA - Eur J Intern Med JT - European journal of internal medicine JID - 9003220 SB - IM MH - Cohort Studies MH - *Connective Tissue Diseases/complications/epidemiology MH - Female MH - Follow-Up Studies MH - Humans MH - Incidence MH - *Lung Diseases, Interstitial/epidemiology MH - Retrospective Studies OTO - NOTNLM OT - Antisynthetase syndrome OT - Connective tissue disease OT - Interstitial lung disease OT - Interstitial pneumonia with autoimmune features OT - Systemic sclerosis EDAT- 2021/12/27 06:00 MHDA- 2022/04/29 06:00 CRDT- 2021/12/26 20:27 PHST- 2021/09/10 00:00 [received] PHST- 2021/11/05 00:00 [revised] PHST- 2021/12/17 00:00 [accepted] PHST- 2021/12/27 06:00 [pubmed] PHST- 2022/04/29 06:00 [medline] PHST- 2021/12/26 20:27 [entrez] AID - S0953-6205(21)00432-5 [pii] AID - 10.1016/j.ejim.2021.12.021 [doi] PST - ppublish SO - Eur J Intern Med. 2022 Mar;97:62-68. doi: 10.1016/j.ejim.2021.12.021. Epub 2021 Dec 23.