PMID- 34954329
OWN - NLM
STAT- MEDLINE
DCOM- 20220321
LR  - 20220321
IS  - 1873-5118 (Electronic)
IS  - 0301-0082 (Linking)
VI  - 210
DP  - 2022 Mar
TI  - Functionally-distinct pyramidal cell subpopulations during gamma oscillations in 
      mouse hippocampal area CA3.
PG  - 102213
LID - S0301-0082(21)00227-6 [pii]
LID - 10.1016/j.pneurobio.2021.102213 [doi]
AB  - Gamma oscillations (gamma-oscillations) in hippocampal area CA3 are essential for 
      memory function. Particularly, CA3 is involved in the memory related process 
      pattern completion, which is linked with the gamma-oscillations in human hippocampus. 
      Recent studies suggest that heterogeneity in the functional properties of 
      pyramidal cells (PCs) in CA3 plays an important role in hippocampal function. By 
      performing concomitant recordings of PC activity and network gamma-oscillations in 
      CA3 we found three functionally-different PC subpopulations. PCs with high 
      spike-frequency adaptation (hA(PC)) have the strongest action potential gamma 
      phase-coupling, PCs with low adaptation (lA(PC)) show lower phase-coupling and 
      PCs displaying a burst-firing pattern (B(PC)) remained quiescent. In addition, we 
      discovered that hA(PC) display the highest excitatory/inhibitory drive, followed 
      by lA(PC), and lastly B(PC). In conclusion, our data advance the hypothesis that 
      PCs in CA3 are organized into subpopulations with distinct functional roles for 
      cognition-relevant network dynamics and provide new insights in the physiology of 
      hippocampus.
CI  - Copyright (c) 2021. Published by Elsevier Ltd.
FAU - Balleza-Tapia, Hugo
AU  - Balleza-Tapia H
AD  - Neuronal Oscillations Laboratory, Division of Neurogeriatrics, Center for 
      Alzheimer Research, Dept. of Neurobiology, Care Sciences and Society, Karolinska 
      Institutet, 17164, Solna, Sweden. Electronic address: h.bllz.tp@gmail.com.
FAU - Arroyo-Garcia, Luis Enrique
AU  - Arroyo-Garcia LE
AD  - Neuronal Oscillations Laboratory, Division of Neurogeriatrics, Center for 
      Alzheimer Research, Dept. of Neurobiology, Care Sciences and Society, Karolinska 
      Institutet, 17164, Solna, Sweden.
FAU - Isla, Arturo G
AU  - Isla AG
AD  - Neuronal Oscillations Laboratory, Division of Neurogeriatrics, Center for 
      Alzheimer Research, Dept. of Neurobiology, Care Sciences and Society, Karolinska 
      Institutet, 17164, Solna, Sweden.
FAU - Loera-Valencia, Raul
AU  - Loera-Valencia R
AD  - Division of Neurogeriatrics, Center for Alzheimer Research, Dept. of 
      Neurobiology, Care Sciences and Society, Karolinska Institutet, 17164, Solna, 
      Sweden.
FAU - Fisahn, Andre
AU  - Fisahn A
AD  - Neuronal Oscillations Laboratory, Division of Neurogeriatrics, Center for 
      Alzheimer Research, Dept. of Neurobiology, Care Sciences and Society, Karolinska 
      Institutet, 17164, Solna, Sweden. Electronic address: andre.fisahn@ki.se.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20211224
PL  - England
TA  - Prog Neurobiol
JT  - Progress in neurobiology
JID - 0370121
SB  - IM
MH  - Action Potentials/physiology
MH  - Animals
MH  - *CA3 Region, Hippocampal/physiology
MH  - Hippocampus
MH  - Humans
MH  - Interneurons/physiology
MH  - Mice
MH  - *Pyramidal Cells
OTO - NOTNLM
OT  - Adaptation
OT  - Gamma oscillations
OT  - Hippocampus
OT  - Pyramidal cells
OT  - Subpopulations
EDAT- 2021/12/27 06:00
MHDA- 2022/03/22 06:00
CRDT- 2021/12/26 20:41
PHST- 2021/06/11 00:00 [received]
PHST- 2021/12/09 00:00 [revised]
PHST- 2021/12/22 00:00 [accepted]
PHST- 2021/12/27 06:00 [pubmed]
PHST- 2022/03/22 06:00 [medline]
PHST- 2021/12/26 20:41 [entrez]
AID - S0301-0082(21)00227-6 [pii]
AID - 10.1016/j.pneurobio.2021.102213 [doi]
PST - ppublish
SO  - Prog Neurobiol. 2022 Mar;210:102213. doi: 10.1016/j.pneurobio.2021.102213. Epub 
      2021 Dec 24.