PMID- 34954646 OWN - NLM STAT- MEDLINE DCOM- 20220316 LR - 20231213 IS - 1873-6750 (Electronic) IS - 0160-4120 (Linking) VI - 160 DP - 2022 Feb TI - Thirdhand smoke from tobacco, e-cigarettes, cannabis, methamphetamine and cocaine: Partitioning, reactive fate, and human exposure in indoor environments. PG - 107063 LID - S0160-4120(21)00688-7 [pii] LID - 10.1016/j.envint.2021.107063 [doi] AB - A source of chemical exposure to humans, thirdhand smoke (THS) refers to the contamination that persists indoors following the cessation of a smoking event. The composition of thirdhand smoke depends on the type of substance from which it originates. Although past studies have investigated the effects of tobacco THS on indoor air quality and human health, few have focused on the chemical composition and health impacts of other sources and components of THS. Here we review the state of knowledge of the composition and partitioning behavior of various types of indoor THS, with a focus on THS from tobacco, e-cigarettes, cannabis, and illicit substances (methamphetamine and cocaine). The discussion is supplemented by estimates of human exposure to THS components made with a chemical fate and exposure model. The modeling results show that while very volatile THS compounds (i.e., aromatics) are likely to be taken up by inhalation, highly water-soluble compounds tended to be dermally absorbed. Conversely, minimally volatile THS compounds with low solubility are predicted to be ingested through hand-to-mouth and object-to-mouth contact. CI - Copyright (c) 2021 The Authors. Published by Elsevier Ltd.. All rights reserved. FAU - Yeh, Kristen AU - Yeh K AD - Department of Chemistry, University of Toronto, 80 St. George Street, Toronto, ON M5S 3H6, Canada. Electronic address: kristen.yeh@mail.utoronto.ca. FAU - Li, Li AU - Li L AD - School of Public Health, University of Nevada Reno, Reno, NV 89557, United States. FAU - Wania, Frank AU - Wania F AD - Department of Physical and Environmental Sciences, University of Toronto Scarborough, 1265 Military Trail, Toronto, Ontario M1C 1A4, Canada. FAU - Abbatt, Jonathan P D AU - Abbatt JPD AD - Department of Chemistry, University of Toronto, 80 St. George Street, Toronto, ON M5S 3H6, Canada. LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't PT - Research Support, U.S. Gov't, Non-P.H.S. PT - Review DEP - 20211223 PL - Netherlands TA - Environ Int JT - Environment international JID - 7807270 RN - 0 (Tobacco Smoke Pollution) RN - 44RAL3456C (Methamphetamine) RN - I5Y540LHVR (Cocaine) SB - IM MH - *Air Pollution, Indoor/analysis MH - *Cannabis MH - *Cocaine MH - *Electronic Nicotine Delivery Systems MH - Humans MH - *Methamphetamine MH - Nicotiana MH - *Tobacco Smoke Pollution/adverse effects/analysis OTO - NOTNLM OT - Cannabis OT - Cocaine OT - E-cigarette OT - Methamphetamine OT - Thirdhand smoke OT - Tobacco EDAT- 2021/12/27 06:00 MHDA- 2022/03/17 06:00 CRDT- 2021/12/26 20:55 PHST- 2021/10/01 00:00 [received] PHST- 2021/12/19 00:00 [revised] PHST- 2021/12/21 00:00 [accepted] PHST- 2021/12/27 06:00 [pubmed] PHST- 2022/03/17 06:00 [medline] PHST- 2021/12/26 20:55 [entrez] AID - S0160-4120(21)00688-7 [pii] AID - 10.1016/j.envint.2021.107063 [doi] PST - ppublish SO - Environ Int. 2022 Feb;160:107063. doi: 10.1016/j.envint.2021.107063. Epub 2021 Dec 23.