PMID- 34954948
OWN - NLM
STAT- MEDLINE
DCOM- 20220216
LR  - 20220216
IS  - 0529-5815 (Print)
IS  - 0529-5815 (Linking)
VI  - 60
IP  - 1
DP  - 2022 Jan 1
TI  - [Mid- and long-term outcomes and prognostic factors of drug-coated balloon 
      angioplasty for treatment of femoropopliteal long lesions].
PG  - 57-62
LID - 10.3760/cma.j.cn112139-20210831-00405 [doi]
AB  - Objective: To examine the effective and safe outcomes of drug-coated balloon 
      (DCB) angioplasty for the treatment of femoropopliteal long lesions in mid-term 
      and long-term follow-up. Methods: The clinical data of 114 patients with 
      symptomatic (Rutherford 2 to 6) femoropopliteal long lesions who underwent 
      angioplasty with DCB between June 2016 and May 2021 at Department of Vascular 
      Surgery,Beijing Tsinghua Changgung Hospital were retrospectively analyzed. A 
      total of 75 males and 39 females were enrolled, aged (71.9+/-8.4)years (range: 49 
      to 89 years). Among 138 lesions in 114 patients, there were 111 de nove lesions 
      (80.4%, 111/138). Total occlusions were recanalized in 116 limbs (84.1%, 
      116/138). The lesion length was (280.9+/-78.7)mm (range: 150 to 520 mm). DCB 
      angioplasty combined with debulking devices was used in 59 lesions (42.8%, 
      59/138).The bail-out stent implantation was performed in 27 limbs (19.6%, 
      27/138). The Kaplan-Meier method was used to evaluate cumulative primary patency 
      rate, freedom from the clinically driven target lesion revascularization (CD-TLR) 
      rate and accumulate survival rate. Univariate and multivariate analyses with Cox 
      proportional hazards models were performed to determine the significant 
      prognostic factors for primary patency. Results: DCB angioplasty was completed in 
      114 patients. The technical success rate was 98.2%(112/114). The mean follow-up 
      time was 18 months (range: 3 to 54 months).The results showed that primary 
      patency rates at 12, 24 and 36 months postoperatively were 87.5%, 75.2% and 
      55.1%, respectively. Freedom from CD-TLR rate at 12, 24 and 36 months 
      postoperatively were 92.4%, 81.8% and 68.7%, respectively. Accumulate survival 
      rate at 12, 24 and 36 months postoperatively were 96.2%, 94.0% and 80.2%. 
      Multivariate Cox's regression analyses showed that chronic limb-threatening 
      ischemia(CLTI) (HR=2.629, 95%CI:1.519 to 4.547, P<0.01) and hyperlipidemia 
      (HR=2.228, 95%CI: 1.004 to 4.948, P=0.026) were independent prognosis factors for 
      primary patency in DCB treatment of femoropopliteal long lesions. Conclusions: 
      DCB provided favorable outcomes for the treatment of femoropopliteal long 
      lesions. CLTI and hyperlipidemia are independent prognosis factors for restenosis 
      after DCB angioplasty.
FAU - Cao, Z J
AU  - Cao ZJ
AD  - Department of Vascular Surgery,Beijing Tsinghua Changgung Hospital,School of 
      Clinical Medicine,Tsinghua University,Beijing 102218,China.
FAU - Zhang, T
AU  - Zhang T
AD  - Department of Vascular Surgery,Beijing Tsinghua Changgung Hospital,School of 
      Clinical Medicine,Tsinghua University,Beijing 102218,China.
FAU - Zhao, K Q
AU  - Zhao KQ
AD  - Department of Vascular Surgery,Beijing Tsinghua Changgung Hospital,School of 
      Clinical Medicine,Tsinghua University,Beijing 102218,China.
FAU - Zhao, J L
AU  - Zhao JL
AD  - Department of Vascular Surgery,Beijing Tsinghua Changgung Hospital,School of 
      Clinical Medicine,Tsinghua University,Beijing 102218,China.
FAU - Yu, X H
AU  - Yu XH
AD  - Department of Vascular Surgery,Beijing Tsinghua Changgung Hospital,School of 
      Clinical Medicine,Tsinghua University,Beijing 102218,China.
FAU - Li, Y W
AU  - Li YW
AD  - Department of Vascular Surgery,Beijing Tsinghua Changgung Hospital,School of 
      Clinical Medicine,Tsinghua University,Beijing 102218,China.
FAU - Wu, W W
AU  - Wu WW
AD  - Department of Vascular Surgery,Beijing Tsinghua Changgung Hospital,School of 
      Clinical Medicine,Tsinghua University,Beijing 102218,China.
LA  - chi
GR  - 12018C0010/Beijing Tsinghua Changgung Hospital Fund/
PT  - Journal Article
PL  - China
TA  - Zhonghua Wai Ke Za Zhi
JT  - Zhonghua wai ke za zhi [Chinese journal of surgery]
JID - 0153611
RN  - 0 (Coated Materials, Biocompatible)
RN  - 0 (Pharmaceutical Preparations)
SB  - IM
MH  - Aged
MH  - *Angioplasty, Balloon
MH  - Coated Materials, Biocompatible
MH  - Female
MH  - Femoral Artery
MH  - Humans
MH  - Male
MH  - *Peripheral Arterial Disease
MH  - *Pharmaceutical Preparations
MH  - Popliteal Artery
MH  - Prognosis
MH  - Retrospective Studies
MH  - Risk Factors
MH  - Time Factors
MH  - Treatment Outcome
MH  - Vascular Patency
EDAT- 2021/12/27 06:00
MHDA- 2022/02/17 06:00
CRDT- 2021/12/26 21:23
PHST- 2021/12/27 06:00 [pubmed]
PHST- 2022/02/17 06:00 [medline]
PHST- 2021/12/26 21:23 [entrez]
AID - 10.3760/cma.j.cn112139-20210831-00405 [doi]
PST - ppublish
SO  - Zhonghua Wai Ke Za Zhi. 2022 Jan 1;60(1):57-62. doi: 
      10.3760/cma.j.cn112139-20210831-00405.