PMID- 34956520
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20211228
IS  - 1943-8141 (Print)
IS  - 1943-8141 (Electronic)
IS  - 1943-8141 (Linking)
VI  - 13
IP  - 11
DP  - 2021
TI  - Effects of epidural block anesthesia combined with general anesthesia on 
      inflammatory factors, cognitive function and postoperative pain in patients with 
      lung cancer after thoracoscopic surgery.
PG  - 13024-13033
AB  - OBJECTIVE: To investigate the effects of epidural block anesthesia combined with 
      general anesthesia on inflammatory factors, cognitive function and postoperative 
      pain in patients with lung cancer after thoracoscopic surgery. METHODS: A total 
      of 144 lung cancer patients admitted to the Department of Cardiothoracic Surgery 
      of Ganzi Tibetan Autonomous Prefecture People's Hospital from October 2017 to 
      October 2019 were included in this retrospective cohort study. The patients were 
      divided into an observation group and a control group, with 72 cases in each 
      group. Observation group was treated with epidural block anesthesia plus general 
      anesthesia under thoracoscopic surgery, while control group was treated with 
      general anesthesia alone. General information of both groups was compared. Tumor 
      necrosis factor-alpha (TNF-alpha) and interleukin-6 (IL-6) levels were measured by 
      enzyme-linked immunosorbent assay before anesthesia (T0), before the end of 
      operation (T1), 12 h after operation (T2) and 24 h after operation (T3). 
      Calcium-binding protein (S-100beta) content, mini-mental state examination (MMSE) 
      and Montreal cognitive assessment (MoCA) at T0, T3, the 3rd day after operation 
      (T4), and the 5th day after operation (T5) were measured. And postoperative pain 
      was recorded. RESULTS: There were no significant differences in TNF-alpha, IL-6, MMSE 
      and MoCA between the two groups at T0, and no significant differences were seen 
      in S-100beta between the two groups at T0 and T1 (all P>0.05). Compared with control 
      group, observation group had lower TNF-alpha and IL-6 at T1, T2, T3, T4 and T5, and 
      lower S-100beta at T3, T4 and T5 (all P<0.001). Lower pain scores and higher MMSE 
      and MoCA were found in the observation group at T3, T4 and T5 (all P<0.05). 
      CONCLUSION: Epidural block anesthesia combined with general anesthesia can 
      effectively reduce levels of inflammatory factors, cognitive disorder and 
      postoperative pain in patients with lung cancer after thoracoscopic surgery.
CI  - AJTR Copyright (c) 2021.
FAU - Luo, Xiaoqin
AU  - Luo X
AD  - Department of Anesthesiology, Ganzi Tibetan Autonomous Prefecture People's 
      Hospital Kangding 626000, Sichuan Province, China.
FAU - Li, Dong
AU  - Li D
AD  - Department of Anesthesiology, Ganzi Tibetan Autonomous Prefecture People's 
      Hospital Kangding 626000, Sichuan Province, China.
LA  - eng
PT  - Journal Article
DEP - 20211115
PL  - United States
TA  - Am J Transl Res
JT  - American journal of translational research
JID - 101493030
PMC - PMC8661174
OTO - NOTNLM
OT  - Epidural block anesthesia
OT  - S-100beta
OT  - general anesthesia
OT  - inflammatory factor
OT  - postoperative cognition
OT  - thoracoscopic surgery
COIS- None.
EDAT- 2021/12/28 06:00
MHDA- 2021/12/28 06:01
PMCR- 2021/11/15
CRDT- 2021/12/27 06:27
PHST- 2021/04/19 00:00 [received]
PHST- 2021/08/19 00:00 [accepted]
PHST- 2021/12/27 06:27 [entrez]
PHST- 2021/12/28 06:00 [pubmed]
PHST- 2021/12/28 06:01 [medline]
PHST- 2021/11/15 00:00 [pmc-release]
PST - epublish
SO  - Am J Transl Res. 2021 Nov 15;13(11):13024-13033. eCollection 2021.