PMID- 34957141
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20211228
IS  - 2296-858X (Print)
IS  - 2296-858X (Electronic)
IS  - 2296-858X (Linking)
VI  - 8
DP  - 2021
TI  - Trajectory and Correlation of Intrinsic Capacity and Frailty in a Beijing Elderly 
      Community.
PG  - 751586
LID - 10.3389/fmed.2021.751586 [doi]
LID - 751586
AB  - Objectives: The World Health Organization proposed intrinsic capacity (IC) model 
      to guide the implementation of person-centered care plan aimed at preserving or 
      reserving functional ability, especially in frail older adults. We aimed to show 
      the trajectory of IC and the overlap between IC impairment and frailty and 
      investigate the correlation between IC domains and frailty status transitions. 
      Method: Longitudinal observational study covering 230 community-dwelling older 
      adults (mean age 84.0 +/- 4.5 years) at baseline, and transition information at 
      2-year follow-up (n = 196). IC was measured by five domains: locomotion, 
      cognition, vitality, psychological, and sensory. Frailty was defined by FRAIL 
      Scale. IC and frailty status transitions were assessed. Logistic regression, odds 
      ratios (OR) and 95% confidence interval (CI) were used for the analysis. Results: 
      The prevalence of frailty was 23.0% and increased up to 41.8% over two years. 
      Regarding frailty transitions, 38.3% of older adults progressed to more frailty 
      status, and 8.6% regressed to lesser frailty status. The prevalence of IC 
      impairment was 67.9% and increased to 81.6% over two years. Regarding IC 
      transitions, 49.2% of adults with no IC impairment at baseline kept stable, and 
      50.8% developed new IC impairment. Among individuals with IC impairment at 
      baseline, 57.9% worsened, and 13.5% improved. Importantly, IC impairment at 
      baseline existed in 42.4% robust adults, 83.3% pre-frail adults, and 93.3% frail 
      adults. 47.1% individuals who kept non-frail status within two years experienced 
      IC worsened transition. Univariable analysis illustrated that new impaired 
      locomotion, vitality, cognition, and sensory domains increased the risk of 
      non-frail progressed to frail status. After adjusting for covariables, new 
      impaired locomotion (OR = 3.625, 95% CI: 1.348-9.747) and vitality domains (OR = 
      3.034, 95% CI: 1.229-7.487) were associated with a higher possibility of 
      non-frail progressed to frail status. Conclusion: IC impairment and frailty 
      overlap and co-exist in older adults. IC impairment, especially new impairment in 
      locomotion and vitality are associated with the transitions from non-frail to 
      frail status. It is important that geriatricians tightly monitor IC trajectory 
      and find the new impaired domains to take early action to minimize the public 
      health burden of frailty.
CI  - Copyright (c) 2021 Liu, Kang, Liu, Zhao, Wang, Li and Jiang.
FAU - Liu, Shuo
AU  - Liu S
AD  - Department of Geriatrics, Peking Union Medical College, Peking Union Medical 
      College Hospital, Chinese Academy of Medical Sciences, Beijing, China.
FAU - Kang, Lin
AU  - Kang L
AD  - Department of Geriatrics, Peking Union Medical College, Peking Union Medical 
      College Hospital, Chinese Academy of Medical Sciences, Beijing, China.
FAU - Liu, XiaoHong
AU  - Liu X
AD  - Department of Geriatrics, Peking Union Medical College, Peking Union Medical 
      College Hospital, Chinese Academy of Medical Sciences, Beijing, China.
FAU - Zhao, SongQi
AU  - Zhao S
AD  - Taikang Yanyuan Continuing Care Retirement Community, Beijing, China.
AD  - Yanyuan Rehabilitation Hospital, Beijing, China.
FAU - Wang, XuePing
AU  - Wang X
AD  - Department of Geriatrics, Affiliated Hospital of QingHai University, Xining, 
      China.
FAU - Li, JiaoJiao
AU  - Li J
AD  - Department of Geriatrics, Peking Union Medical College, Peking Union Medical 
      College Hospital, Chinese Academy of Medical Sciences, Beijing, China.
FAU - Jiang, Shan
AU  - Jiang S
AD  - Department of Geriatrics, The Key Laboratory of Geriatrics, Beijing Institute of 
      Geriatrics, Beijing Hospital, National Center of Gerontology, National Health 
      Commission, Institute of Geriatric Medicine, Chinese Academy of Medical Sciences, 
      Beijing, China.
LA  - eng
PT  - Journal Article
DEP - 20211209
PL  - Switzerland
TA  - Front Med (Lausanne)
JT  - Frontiers in medicine
JID - 101648047
PMC - PMC8695757
OTO - NOTNLM
OT  - frailty
OT  - intrinsic capacity
OT  - older adults
OT  - trajectory
OT  - transitions
COIS- The authors declare that the research was conducted in the absence of any 
      commercial or financial relationships that could be construed as a potential 
      conflict of interest.
EDAT- 2021/12/28 06:00
MHDA- 2021/12/28 06:01
PMCR- 2021/12/09
CRDT- 2021/12/27 06:33
PHST- 2021/08/01 00:00 [received]
PHST- 2021/11/11 00:00 [accepted]
PHST- 2021/12/27 06:33 [entrez]
PHST- 2021/12/28 06:00 [pubmed]
PHST- 2021/12/28 06:01 [medline]
PHST- 2021/12/09 00:00 [pmc-release]
AID - 10.3389/fmed.2021.751586 [doi]
PST - epublish
SO  - Front Med (Lausanne). 2021 Dec 9;8:751586. doi: 10.3389/fmed.2021.751586. 
      eCollection 2021.