PMID- 34957246
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20231103
IS  - 2297-055X (Print)
IS  - 2297-055X (Electronic)
IS  - 2297-055X (Linking)
VI  - 8
DP  - 2021
TI  - Cardiovascular Risk Factors and Hemodynamic Measures as Determinants of Increased 
      Arterial Stiffness Following Surgical Aortic Valve Replacement.
PG  - 754371
LID - 10.3389/fcvm.2021.754371 [doi]
LID - 754371
AB  - Valvular and arterial function are tightly intertwined, both in terms of 
      structural changes and hemodynamics. While proximal valvulo-vascular coupling 
      contributes to the cardiovascular consequences of aortic stenosis, less is known 
      on how peripheral arterial stiffness relates to aortic valve disease. Previous 
      studies have shown conflicting results regarding the impact of aortic valve 
      replacement on arterial stiffness. The aim of the present study was therefore to 
      determine predictors of arterial stiffness in patients with and without aortic 
      valve disease undergoing cardiac surgery. Cardio ankle vascular index (CAVI) and 
      carotid femoral pulse wave velocity (cfPWV) were measured to determine arterial 
      stiffness the day before and 3 days after surgery for either ascending aortic or 
      aortic valve disease. Stratification on indication for surgery revealed that CAVI 
      was significantly lower in patients with aortic valve stenosis (n = 45) and 
      aortic valve regurgitation (n=30) compared with those with isolated ascending 
      aortic dilatation (n = 13). After surgery, a significant increased CAVI was 
      observed in aortic stenosis (median 1.34, IQR 0.74-2.26, p < 0.001) and 
      regurgitation (median 1.04, IQR 0.01-1.49, p = 0.003) patients while cfPWV was 
      not significantly changed. Age, diabetes, low body mass index, low pre-operative 
      CAVI, as well as changes in ejection time were independently associated with 
      increased CAVI after surgery. The results of the present study suggest aortic 
      valve disease as cause of underestimation of arterial stiffness when including 
      peripheral segments. We report cardiovascular risk factors and pinpoint the 
      hemodynamic aspect ejection time to be associated with increased CAVI after 
      aortic valve surgery.
CI  - Copyright (c) 2021 Plunde, Franco-Cereceda and Back.
FAU - Plunde, Oscar
AU  - Plunde O
AD  - Unit of Cardiovascular Medicine, Department of Medicine Solna, Karolinska 
      Institutet, Stockholm, Sweden.
AD  - Theme Heart and Vessels, Division of Valvular and Coronary Disease, Karolinska 
      University Hospital, Stockholm, Sweden.
FAU - Franco-Cereceda, Anders
AU  - Franco-Cereceda A
AD  - Theme Heart and Vessels, Division of Valvular and Coronary Disease, Karolinska 
      University Hospital, Stockholm, Sweden.
AD  - Cardiothoracic Surgery Unit, Department of Molecular Medicine and Surgery, 
      Karolinska Institutet, Stockholm, Sweden.
FAU - Back, Magnus
AU  - Back M
AD  - Unit of Cardiovascular Medicine, Department of Medicine Solna, Karolinska 
      Institutet, Stockholm, Sweden.
AD  - Theme Heart and Vessels, Division of Valvular and Coronary Disease, Karolinska 
      University Hospital, Stockholm, Sweden.
LA  - eng
PT  - Journal Article
DEP - 20211208
PL  - Switzerland
TA  - Front Cardiovasc Med
JT  - Frontiers in cardiovascular medicine
JID - 101653388
PMC - PMC8692982
OTO - NOTNLM
OT  - aortic
OT  - aortic regurgitation
OT  - aortic stenosis
OT  - aortic stiffness
OT  - arterial stiffness
OT  - surgical aortic valve replacement
COIS- The authors declare that the research was conducted in the absence of any 
      commercial or financial relationships that could be construed as a potential 
      conflict of interest. The reviewer TK declared a shared affiliation with several 
      of the authors, OP, AF-C, and MB, and to the handling editor at time of review.
EDAT- 2021/12/28 06:00
MHDA- 2021/12/28 06:01
PMCR- 2021/01/01
CRDT- 2021/12/27 06:34
PHST- 2021/08/06 00:00 [received]
PHST- 2021/11/11 00:00 [accepted]
PHST- 2021/12/27 06:34 [entrez]
PHST- 2021/12/28 06:00 [pubmed]
PHST- 2021/12/28 06:01 [medline]
PHST- 2021/01/01 00:00 [pmc-release]
AID - 10.3389/fcvm.2021.754371 [doi]
PST - epublish
SO  - Front Cardiovasc Med. 2021 Dec 8;8:754371. doi: 10.3389/fcvm.2021.754371. 
      eCollection 2021.