PMID- 34958303
OWN - NLM
STAT- MEDLINE
DCOM- 20220401
LR  - 20220401
IS  - 0722-5091 (Print)
IS  - 0722-5091 (Linking)
VI  - 41
IP  - 2
DP  - 2022 Mar-Apr
TI  - Cerebral amyloidomas: Perspective on unusual morphological features.
PG  - 46-52
LID - 10.5414/NP301440 [doi]
AB  - AIMS: Cerebral amyloidomas (CAs) are mass-producing congophilic lesions most 
      commonly due to lambda light chain deposits, contrasting them with light chain 
      deposition disease (LCDD) which has non-polarizable, often kappa light chain 
      deposition. MATERIALS AND METHODS: Although usual histological features are well 
      known, we detail 3 recent CAs with unusual morphological findings and review the 
      literature specifically for these features. RESULTS: Two women, aged 56 and 58 
      years, had right cerebral white matter CAs. The biopsy of case 1 disclosed 
      congophilic polarizable deposits with prominent dystrophic mineralization as well 
      as scant plasma cells. Case 2 had a CA with significant multinucleated giant cell 
      reaction to the amyloid and additionally contained an area suspicious for 
      marginal zone B-cell lymphoma. Case 3 was a clinically unsuspected CA identified 
      at autopsy in a 75-year-old woman that manifested as several contiguous left 
      frontal lobe white matter erythematous, hyperemic lesions; microscopy showed 
      nodular and concentric amyloid deposits and thick perivascular cuffs of plasma 
      cells. Mass spectrometry proved lambda light and alpha heavy chain amyloid deposits in all 
      3 cases. CONCLUSION: These 3 CA cases illustrate several unusual gross and 
      microscopic features that are discussed in context with the literature.
FAU - Kleinschmidt-DeMasters, Bette K
AU  - Kleinschmidt-DeMasters BK
LA  - eng
PT  - Case Reports
PT  - Journal Article
PL  - Germany
TA  - Clin Neuropathol
JT  - Clinical neuropathology
JID - 8214420
RN  - 0 (Amyloid)
SB  - IM
MH  - Aged
MH  - Amyloid/analysis
MH  - *Amyloidosis/diagnosis/pathology
MH  - Female
MH  - Humans
MH  - *Lymphoma, B-Cell/pathology
MH  - Middle Aged
MH  - Plasma Cells/pathology
MH  - *Soft Tissue Neoplasms/pathology
EDAT- 2021/12/28 06:00
MHDA- 2022/04/02 06:00
CRDT- 2021/12/27 12:13
PHST- 2022/02/10 00:00 [accepted]
PHST- 2021/12/28 06:00 [pubmed]
PHST- 2022/04/02 06:00 [medline]
PHST- 2021/12/27 12:13 [entrez]
AID - 189088 [pii]
AID - 10.5414/NP301440 [doi]
PST - ppublish
SO  - Clin Neuropathol. 2022 Mar-Apr;41(2):46-52. doi: 10.5414/NP301440.