PMID- 34958390
OWN - NLM
STAT- MEDLINE
DCOM- 20220405
LR  - 20240219
IS  - 1541-6100 (Electronic)
IS  - 0022-3166 (Print)
IS  - 0022-3166 (Linking)
VI  - 152
IP  - 4
DP  - 2022 Apr 1
TI  - Biology of Activating Transcription Factor 4 (ATF4) and Its Role in Skeletal 
      Muscle Atrophy.
PG  - 926-938
LID - S0022-3166(23)10558-X [pii]
LID - 10.1093/jn/nxab440 [doi]
AB  - Activating transcription factor 4 (ATF4) is a multifunctional transcription 
      regulatory protein in the basic leucine zipper superfamily. ATF4 can be expressed 
      in most if not all mammalian cell types, and it can participate in a variety of 
      cellular responses to specific environmental stresses, intracellular 
      derangements, or growth factors. Because ATF4 is involved in a wide range of 
      biological processes, its roles in human health and disease are not yet fully 
      understood. Much of our current knowledge about ATF4 comes from investigations in 
      cultured cell models, where ATF4 was originally characterized and where further 
      investigations continue to provide new insights. ATF4 is also an increasingly 
      prominent topic of in vivo investigations in fully differentiated mammalian cell 
      types, where our current understanding of ATF4 is less complete. Here, we review 
      some important high-level concepts and questions concerning the basic biology of 
      ATF4. We then discuss current knowledge and emerging questions about the in vivo 
      role of ATF4 in one fully differentiated cell type, mammalian skeletal muscle 
      fibers.
CI  - (c) The Author(s) 2021. Published by Oxford University Press on behalf of the 
      American Society for Nutrition.
FAU - Ebert, Scott M
AU  - Ebert SM
AD  - Department of Internal Medicine, Division of Endocrinology, Diabetes, Metabolism 
      and Nutrition, Mayo Clinic, Rochester, MN, USA.
AD  - Emmyon, Inc., Rochester, MN, USA.
FAU - Rasmussen, Blake B
AU  - Rasmussen BB
AD  - Emmyon, Inc., Rochester, MN, USA.
AD  - Department of Nutrition, Metabolism and Rehabilitation Sciences, University of 
      Texas Medical Branch, Galveston, TX, USA.
FAU - Judge, Andrew R
AU  - Judge AR
AD  - Emmyon, Inc., Rochester, MN, USA.
AD  - Department of Physical Therapy, University of Florida, Gainesville, FL, USA.
FAU - Judge, Sarah M
AU  - Judge SM
AD  - Department of Physical Therapy, University of Florida, Gainesville, FL, USA.
FAU - Larsson, Lars
AU  - Larsson L
AD  - Department of Physiology and Pharmacology, Karolinska, Stockholm, Sweden.
FAU - Wek, Ronald C
AU  - Wek RC
AD  - Department of Biochemistry and Molecular Biology, Indiana University, 
      Indianapolis, IN, USA.
FAU - Anthony, Tracy G
AU  - Anthony TG
AD  - Department of Nutritional Sciences, Rutgers University, New Brunswick, NJ, USA.
FAU - Marcotte, George R
AU  - Marcotte GR
AD  - Department of Internal Medicine, Division of Endocrinology, Diabetes, Metabolism 
      and Nutrition, Mayo Clinic, Rochester, MN, USA.
AD  - Department of Internal Medicine, University of Iowa, Iowa City, IA, USA.
FAU - Miller, Matthew J
AU  - Miller MJ
AD  - Department of Internal Medicine, Division of Endocrinology, Diabetes, Metabolism 
      and Nutrition, Mayo Clinic, Rochester, MN, USA.
AD  - Department of Internal Medicine, University of Iowa, Iowa City, IA, USA.
FAU - Yorek, Mark A
AU  - Yorek MA
AD  - Department of Internal Medicine, University of Iowa, Iowa City, IA, USA.
AD  - Department of Internal Medicine, Iowa City VA Medical Center, Iowa City, IA, USA.
FAU - Vella, Adrian
AU  - Vella A
AUID- ORCID: 0000-0001-6493-7837
AD  - Department of Internal Medicine, Division of Endocrinology, Diabetes, Metabolism 
      and Nutrition, Mayo Clinic, Rochester, MN, USA.
AD  - Emmyon, Inc., Rochester, MN, USA.
FAU - Volpi, Elena
AU  - Volpi E
AUID- ORCID: 0000-0001-8776-0384
AD  - Department of Nutrition, Metabolism and Rehabilitation Sciences, University of 
      Texas Medical Branch, Galveston, TX, USA.
FAU - Stern, Jennifer I
AU  - Stern JI
AD  - Department of Internal Medicine, Division of Endocrinology, Diabetes, Metabolism 
      and Nutrition, Mayo Clinic, Rochester, MN, USA.
FAU - Strub, Matthew D
AU  - Strub MD
AD  - Department of Internal Medicine, Division of Endocrinology, Diabetes, Metabolism 
      and Nutrition, Mayo Clinic, Rochester, MN, USA.
FAU - Ryan, Zachary
AU  - Ryan Z
AD  - Department of Internal Medicine, Division of Endocrinology, Diabetes, Metabolism 
      and Nutrition, Mayo Clinic, Rochester, MN, USA.
FAU - Talley, John J
AU  - Talley JJ
AD  - Emmyon, Inc., Rochester, MN, USA.
FAU - Adams, Christopher M
AU  - Adams CM
AD  - Department of Internal Medicine, Division of Endocrinology, Diabetes, Metabolism 
      and Nutrition, Mayo Clinic, Rochester, MN, USA.
AD  - Emmyon, Inc., Rochester, MN, USA.
AD  - Department of Internal Medicine, Iowa City VA Medical Center, Iowa City, IA, USA.
LA  - eng
GR  - I01 BX000976/BX/BLRD VA/United States
GR  - T32 GM139776/GM/NIGMS NIH HHS/United States
GR  - R01 AR060209/AR/NIAMS NIH HHS/United States
GR  - R01 AG060637/AG/NIA NIH HHS/United States
GR  - T32 DK007352/DK/NIDDK NIH HHS/United States
GR  - R01 AR071762/AR/NIAMS NIH HHS/United States
GR  - R01 DK116231/DK/NIDDK NIH HHS/United States
GR  - R01 DK078646/DK/NIDDK NIH HHS/United States
GR  - R01 DK126206/DK/NIDDK NIH HHS/United States
GR  - R01 DK109714/DK/NIDDK NIH HHS/United States
GR  - P30 AG024832/AG/NIA NIH HHS/United States
GR  - R44 AG047684/AG/NIA NIH HHS/United States
GR  - R44 AR069400/AR/NIAMS NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, U.S. Gov't, Non-P.H.S.
PT  - Review
PL  - United States
TA  - J Nutr
JT  - The Journal of nutrition
JID - 0404243
RN  - 0 (ATF4 protein, human)
RN  - 145891-90-3 (Activating Transcription Factor 4)
SB  - IM
MH  - *Activating Transcription Factor 4/genetics/metabolism
MH  - Animals
MH  - Biology
MH  - Cell Differentiation
MH  - Humans
MH  - Mammals
MH  - Muscle Fibers, Skeletal/metabolism
MH  - *Muscular Atrophy/etiology
PMC - PMC8970988
OTO - NOTNLM
OT  - ATF4
OT  - sarcopenia
OT  - skeletal muscle atrophy
OT  - tomatidine
OT  - ursolic acid
EDAT- 2021/12/28 06:00
MHDA- 2022/04/05 06:00
PMCR- 2024/02/18
CRDT- 2021/12/27 12:16
PHST- 2021/10/08 00:00 [received]
PHST- 2021/12/17 00:00 [revised]
PHST- 2021/12/23 00:00 [accepted]
PHST- 2021/12/28 06:00 [pubmed]
PHST- 2022/04/05 06:00 [medline]
PHST- 2021/12/27 12:16 [entrez]
PHST- 2024/02/18 00:00 [pmc-release]
AID - S0022-3166(23)10558-X [pii]
AID - 10.1093/jn/nxab440 [doi]
PST - ppublish
SO  - J Nutr. 2022 Apr 1;152(4):926-938. doi: 10.1093/jn/nxab440.