PMID- 34959636
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20240405
IS  - 1424-8247 (Print)
IS  - 1424-8247 (Electronic)
IS  - 1424-8247 (Linking)
VI  - 14
IP  - 12
DP  - 2021 Nov 28
TI  - The Effect of Curcumin Differs on Individual Cognitive Domains across Different 
      Patient Populations: A Systematic Review and Meta-Analysis.
LID - 10.3390/ph14121235 [doi]
LID - 1235
AB  - Curcumin is a polyphenol with strong antioxidant and anti-inflammatory effects 
      that has been shown to be effective in ameliorating cognitive decline in animal 
      studies. However, its clinical effectiveness is inconclusive, and relevant 
      gastrointestinal adverse events (AEs) have been reported. The aim of this 
      meta-analysis was to summarize the existing evidence from randomized controlled 
      trials (RCTs) of effects of curcumin on overall cognitive function, individual 
      cognitive domains, and gastrointestinal AE. The study includes 8 RCTs and 389 
      participants. A random-effects model was used for the meta-analysis. Compared 
      with the placebo group, the curcumin group was associated with an improvement in 
      working memory (Hedges' g = 0.396, 95% confidence interval (CI) = 0.078 to 0.714, 
      p = 0.015) and a borderline benefit in processing speed (Hedges' g = 0.303, 95% 
      CI = -0.013 to 0.619, p = 0.06). In the domains of language, episodic 
      memory/visual learning, verbal memory, cognitive flexibility/problem solving, and 
      overall cognitive function, no significant difference existed for the comparison 
      between the curcumin and placebo groups. The curcumin group had a significantly 
      higher risk of gastrointestinal AEs than the placebo group (odds ratio = 3.019, 
      95% CI = 1.118 to 8.150, p = 0.029). In the future, the effects of curcumin on 
      working memory, processing speed, and gastrointestinal AE should be further 
      investigated.
FAU - Tsai, I-Chen
AU  - Tsai IC
AUID- ORCID: 0000-0002-4356-918X
AD  - Institute of Clinical Medicine, National Yang Ming Chiao Tung University, Taipei 
      112304, Taiwan.
AD  - Congenital Heart Disease Study Group, Asian Society of Cardiovascular Imaging, 
      Seoul 13572, Korea.
AD  - InnovaRad Inc., Taichung 407004, Taiwan.
FAU - Hsu, Chih-Wei
AU  - Hsu CW
AUID- ORCID: 0000-0002-8650-4060
AD  - Department of Psychiatry, Kaohsiung Chang Gung Memorial Hospital, Chang Gung 
      University College of Medicine, Kaohsiung 83301, Taiwan.
AD  - Department of Computer Science and Information Engineering, National Cheng Kung 
      University, Tainan 70101, Taiwan.
FAU - Chang, Chun-Hung
AU  - Chang CH
AUID- ORCID: 0000-0003-2949-5855
AD  - Institute of Clinical Medical Science, China Medical University, Taichung 404333, 
      Taiwan.
AD  - Department of Psychiatry & Brain Disease Research Center, China Medical 
      University Hospital, Taichung 404332, Taiwan.
AD  - An Nan Hospital, China Medical University, Tainan 709204, Taiwan.
FAU - Tseng, Ping-Tao
AU  - Tseng PT
AUID- ORCID: 0000-0001-5761-7800
AD  - Prospect Clinic for Otorhinolaryngology & Neurology, Kaohsiung 811022, Taiwan.
AD  - Institute of Biomedical Sciences, National Sun Yat-sen University, Kaohsiung 
      804201, Taiwan.
AD  - Department of Psychology, College of Medical and Health Science, Asia University, 
      Taichung 41354, Taiwan.
FAU - Chang, Ke-Vin
AU  - Chang KV
AUID- ORCID: 0000-0002-7558-5651
AD  - Department of Physical Medicine and Rehabilitation, National Taiwan University 
      Hospital, National Taiwan University College of Medicine, Taipei 10048, Taiwan.
AD  - Department of Physical Medicine and Rehabilitation, National Taiwan University 
      Hospital, Bei-Hu Branch, Taipei 10845, Taiwan.
AD  - Center for Regional Anesthesia and Pain Medicine, Wang-Fang Hospital, Taipei 
      Medical University, Taipei 11600, Taiwan.
LA  - eng
GR  - 106-2314-B-002-180-MY3/Ministry of Science and Technology Taiwan/
GR  - 109-2314-B-002-114-MY3/Ministry of Science and Technology Taiwan/
PT  - Journal Article
PT  - Review
DEP - 20211128
PL  - Switzerland
TA  - Pharmaceuticals (Basel)
JT  - Pharmaceuticals (Basel, Switzerland)
JID - 101238453
PMC - PMC8708668
OTO - NOTNLM
OT  - Curcuma longa
OT  - cognition
OT  - cognitive function
OT  - curcumin
OT  - turmeric
COIS- The authors declare no conflict of interest.
EDAT- 2021/12/29 06:00
MHDA- 2021/12/29 06:01
PMCR- 2021/11/28
CRDT- 2021/12/28 01:04
PHST- 2021/11/08 00:00 [received]
PHST- 2021/11/24 00:00 [revised]
PHST- 2021/11/25 00:00 [accepted]
PHST- 2021/12/28 01:04 [entrez]
PHST- 2021/12/29 06:00 [pubmed]
PHST- 2021/12/29 06:01 [medline]
PHST- 2021/11/28 00:00 [pmc-release]
AID - ph14121235 [pii]
AID - pharmaceuticals-14-01235 [pii]
AID - 10.3390/ph14121235 [doi]
PST - epublish
SO  - Pharmaceuticals (Basel). 2021 Nov 28;14(12):1235. doi: 10.3390/ph14121235.