PMID- 34959861 OWN - NLM STAT- MEDLINE DCOM- 20220121 LR - 20240405 IS - 2072-6643 (Electronic) IS - 2072-6643 (Linking) VI - 13 IP - 12 DP - 2021 Nov 29 TI - The Effect of Isolated and Combined Application of Menthol and Carbohydrate Mouth Rinses on 40 km Time Trial Performance, Physiological and Perceptual Measures in the Heat. LID - 10.3390/nu13124309 [doi] LID - 4309 AB - The current study compared mouth swills containing carbohydrate (CHO), menthol (MEN) or a combination (BOTH) on 40 km cycling time trial (TT) performance in the heat (32 degrees C, 40% humidity, 1000 W radiant load) and investigates associated physiological (rectal temperature (Trec), heart rate (HR)) and subjective measures (thermal comfort (TC), thermal sensation (TS), thirst, oral cooling (OC) and RPE (legs and lungs)). Eight recreationally trained male cyclists (32 +/- 9 y; height: 180.9 +/- 7.0 cm; weight: 76.3 +/- 10.4 kg) completed familiarisation and three experimental trials, swilling either MEN, CHO or BOTH at 10 km intervals (5, 15, 25, 35 km). The 40 km TT performance did not differ significantly between conditions (F(2,14) = 0.343; p = 0.715; eta(2) = 0.047), yet post-hoc testing indicated small differences between MEN and CHO (d = 0.225) and MEN and BOTH (d = 0.275). Subjective measures (TC, TS, RPE) were significantly affected by distance but showed no significant differences between solutions. Within-subject analysis found significant interactions between solution and location upon OC intensity (F(28,196) = 2.577; p < 0.001; eta(2) = 0.269). While solutions containing MEN resulted in a greater sensation of OC, solutions containing CHO experienced small improvements in TT performance. Stimulation of central CHO pathways during self-paced cycling TT in the heat may be of more importance to performance than perceptual cooling interventions. However, no detrimental effects are seen when interventions are combined. FAU - Best, Russ AU - Best R AUID- ORCID: 0000-0001-9017-1513 AD - Centre for Sports Science and Human Performance, Waikato Institute of Technology, Hamilton 3200, New Zealand. FAU - Crosby, Seana AU - Crosby S AD - Centre for Sports Science and Human Performance, Waikato Institute of Technology, Hamilton 3200, New Zealand. FAU - Berger, Nicolas AU - Berger N AUID- ORCID: 0000-0001-7276-5246 AD - School of Health and Life Sciences, Teesside University, Middlesbrough TS1 3BX, UK. FAU - McDonald, Kerin AU - McDonald K AD - Centre for Sports Science and Human Performance, Waikato Institute of Technology, Hamilton 3200, New Zealand. LA - eng PT - Journal Article PT - Randomized Controlled Trial DEP - 20211129 PL - Switzerland TA - Nutrients JT - Nutrients JID - 101521595 RN - 0 (Dietary Carbohydrates) RN - 0 (Mouthwashes) RN - 1490-04-6 (Menthol) SB - IM MH - Adult MH - Athletic Performance/*physiology MH - Bicycling/*physiology MH - Body Temperature/drug effects MH - Body Temperature Regulation/drug effects MH - Dietary Carbohydrates/*administration & dosage MH - Double-Blind Method MH - Heart Rate/drug effects MH - Hot Temperature/adverse effects MH - Humans MH - Humidity MH - Male MH - Menthol/*administration & dosage MH - Mouth MH - Mouthwashes/*administration & dosage/chemistry MH - Thermosensing/drug effects MH - Thirst/drug effects PMC - PMC8708984 OTO - NOTNLM OT - carbohydrate OT - cycling OT - endurance OT - heat OT - menthol OT - time trial COIS- The authors declare no conflict of interest. EDAT- 2021/12/29 06:00 MHDA- 2022/01/22 06:00 PMCR- 2021/11/29 CRDT- 2021/12/28 01:05 PHST- 2021/10/30 00:00 [received] PHST- 2021/11/24 00:00 [revised] PHST- 2021/11/28 00:00 [accepted] PHST- 2021/12/28 01:05 [entrez] PHST- 2021/12/29 06:00 [pubmed] PHST- 2022/01/22 06:00 [medline] PHST- 2021/11/29 00:00 [pmc-release] AID - nu13124309 [pii] AID - nutrients-13-04309 [pii] AID - 10.3390/nu13124309 [doi] PST - epublish SO - Nutrients. 2021 Nov 29;13(12):4309. doi: 10.3390/nu13124309.